Evaluation of anti-inflammatory and analgesic effects of Coriandrum sativum extract in mice

MR Heidari; M. Aghil; E. Soltaninezhad

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Evaluation of anti-inflammatory and analgesic effects of Coriandrum sativum extract in mice

Author(s):

MR Heidari^,*,

M. Aghil,

E. Soltaninezhad

Journal of Inflammatory Diseases:Vol. 8, issue 4; 3-8

Article type:Research Article

How to Cite:MR HeidariM. AghilE. SoltaninezhadEvaluation of anti-inflammatory and analgesic effects of Coriandrum sativum extract in mice.J Inflamm Dis.8(4):e155077.

Abstract

Abstract Background: Coriandrum sativum is traditionally being used to relieve toothache, ease migraine and rheumatic arthritis. Objective: The aim of this study was to evaluate the analgesic effect of Coriandrum sativum compared with morphine and ASA. Methods: Percolated and soxhleted methanolic extracts of Coriandrum sativum, in different doses, were injected into mice (IP) and the analgesic effect was determind by formalin and Tail flick tests. This experimental study was carried out in Kerman pharmacy school in 2002. Findings: The results showed that percolated extract in doses of 25, 50, 100, 200mg/kg induced signinificant analgesia compared with the normal saline group. The most effective dose of extract was 50 mg/kg. The analgesic effect of this dose was different from morphine and ASA. Conclusion: Since the naloxone did not induce any significant effect on the analgesic property of extract by Tail flick and formalin test except following 20-25 min in formalin test, so it seems that the opioid receptor may be involved in inflammatory phase.

Keywords

Keywords: Coriander

Traditional Medicine

Anesthesia and Analgesia

Dental Anesthesia

Headache

Migraine

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