Effect of alcoholic extract of Tanacetum parthenium on acute pain in rat

N Parvin; R Ansari Samani; N Shahinfard; S Reissi; Z Alibabaie; A Asgari

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Effect of alcoholic extract of Tanacetum parthenium on acute pain in rat

Author(s):

N Parvin,

R Ansari Samani,

N Shahinfard,

S Reissi,

Z Alibabaie,

A Asgari

Journal of Inflammatory Diseases:Vol. 16, issue 1; 15-21

Article type:Research Article

How to Cite:N ParvinR Ansari SamaniN ShahinfardS ReissiZ AlibabaieA Asgariet al.Effect of alcoholic extract of Tanacetum parthenium on acute pain in rat.J Inflamm Dis.16(1):e155676.

Abstract

Background: The u se of medicinal plants to reduce pain is important. Tanacetum parthenium has been introduced as an analgesic agent in traditional medicine and is widely used to relieve neuropathic pain and headache. Objective: The aim of this study was to investigate the analgesic effect of Tanacetum parthenium ethanolic extract on acute pain. Methods: This study was carried out on 100 male mice weighing 30-35g. Acute pain was investigated using a hot plate test with set point 48 °C and cut off time of 30 seconds. In this experiment 100 mice were divided into 10 groups as follows: 1) control group groups 2-6 received 10, 20, 30, 40 and 80 mg/kg of alcoholic extract, respectively group 7 received 100 mg / kg ibuprofen group 8 received 0.5 mg / kg morphine group 9 received 0.5 mg / kg naloxone and finally group 10 received naloxone and extract. Ethanolic extract of aerial parts was prepared by maceration method and later its analgesic effect was studied at different doses of 10, 20, 30, 40, and 80 mg/kg, i.p. The effect of ethanolic extract and fractions were compared with the analgesic effect of morphine and ibuprofen as standard analgesic drugs. Naloxone was used to study the opioid system. Data were analyzed by SPSS using Kruskal Wallis test. Findings: Results obtained from this study showed that the ethanolic extract of Tanacetum parthenium produced an analgesic effect (P

Keywords

Tanacetum parthenium

Analgesia

Hot plate test

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