Frequency of P and type 1 fimbriae-encoding genes among uropathogenic Escherichia coli isolated from hospitalized patients in Qazvin and Karaj hospitals

M Mahdikhani; A Peymani; Taghi Naserpour Farivar; aslanimehrm aslanimehrm

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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Frequency of P and type 1 fimbriae-encoding genes among uropathogenic Escherichia coli isolated from hospitalized patients in Qazvin and Karaj hospitals

Author(s):

M Mahdikhani¹,

A Peymani^,*,

Taghi Naserpour Farivar²,

aslanimehrm aslanimehrm²

1Islamic Azad Zanjan University

2Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

Journal of Inflammatory Diseases:Vol. 19, issue 3; 35-40

Article type:Research Article

How to Cite:M MahdikhaniA PeymaniTaghi Naserpour Farivaraslanimehrm aslanimehrmFrequency of P and type 1 fimbriae-encoding genes among uropathogenic Escherichia coli isolated from hospitalized patients in Qazvin and Karaj hospitals.J Inflamm Dis.19(3):e155910.

Abstract

Background: Escherichia coli (E. coli) is the most important cause of urinary tract infections in hospitalized patients especially in intensive care unit ( ICU). Colonization of E. coli and its attachment to uroepithelium are mediated by adhesins such as type 1 (fimH) and P (papC) fimbriae. Objective: The aim of this study was to determine the frequency of type 1 and P fimbriae-encoding genes among uropathogenic E.coli in ICUs. Methods: In this descriptive study, 120 clinical isolates of uropathogenic E.coli were collected from patients with urinary tract infection in ICUs of Qazvin and Karaj hospitals during 2013 and 2014. All bacterial isolates were identified by standard laboratory methods and the fimH and papC genes were detected using the PCR method. Findings: Forty (33.3%) isolates were positive for fimH gene and 5 (4.2%) isolates were positive for papC gene. Sixty six (55%) isolates were positive for both genes, and 9 (7.5%) isolates were negative for them. Conclusion: The findings of this study showed the high frequency of type 1 and P fimbriae among uropathogenic E.coli isolates from ICU patients in the studied hospitals. Citation: Mahdikhani M, Peymani A, Naserpour-Farivar T, Aslanimehr M. Frequency of P and type 1 fimbriae among uropathogenic Escherichia coli isolated from hospitalized patients in Qazvin and Karaj hospitals. J Qazvin Univ Med Sci. 2015 19 (3): 35-40.

Keywords

Escherichia coli

FimH Protein

PapC Protein

Urinary Tract Infections

Intensive Care Units

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