Risk factors related to cleft lip and palate in a group of infants in Tehran from 2013 to 2014

roya hamedi; A Ebadifar; sara yousefinia

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Reviewer and AE Registration Form Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Support Contact Us

Authors Guide Submit Manuscript

Risk factors related to cleft lip and palate in a group of infants in Tehran from 2013 to 2014

Author(s):

roya hamedi,

A Ebadifar,

sara yousefinia^,*

Journal of Inflammatory Diseases:Vol. 21, issue 4; 27-20

Article type:Research Article

How to Cite: roya hamediA Ebadifarsara yousefiniaRisk factors related to cleft lip and palate in a group of infants in Tehran from 2013 to 2014.J Inflamm Dis.21(4):e156038.

Abstract

Background: Cleft lip and palate is one of the most common congenital anomalies. The etiology of non syndromic orofacial clefts is multifactorial. Objective: The aim of this study was to evaluate the related risk factors of cleft lip and palate in a group of infants born in Tehran during the years between 2012-2015. Methods: In this case-control study the files of 105 newborns with oral clefts, and 218 normal newborns as control group with their mothers were evaluated in Mofid Hospital in Tehran. Data were analyzed by Chi-square test. Findings: Among 105 cases, 40 cases (38%) were females and 65 cases (62%) were males. The frequency of cleft lip and palate, cleft palate and cleft lip were 58%, 27.6% and 14.2% respectively. A significant relationship was found between parents with familial marriage (P=0.001). The highest number of clefts belonged to 25-35 year-old mothers (51.4%), 41% of mothers reported smoking during pregnancy thus maternal smoking would be an effective predisposing factor to have a child with oral clefts (P=0.001). Conclusion: The results of this study indicate that history of familial matrimony, mother’s age above 35 years and maternal smoking during pregnancy can enhance the risk of orofacial clefts 18, 17 and 14 times respectively. These findings emphasize the importance of preconception counseling of mothers-to-be on amendable lifestyle factors in order to reduce the birth prevalence of cleft lip/ palate in future generations.

Keywords

Lip and palate clefts

Risk factors

Infant

comments