The Effect of NO System on Ethidium Bromide-Induced Oxidative Stress in the Hippocampal Formation of Male Rats

Zahedeh Rhimluoye Marjan; Alireza ali hemmatti; Homeira Hatami; Hatam Ahmadi

Journal of Inflammatory Diseases

The Official Journal of Qazvin University of Medical Sciences

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The Effect of NO System on Ethidium Bromide-Induced Oxidative Stress in the Hippocampal Formation of Male Rats

Author(s):

Zahedeh Rhimluoye Marjan^1,*,

Alireza ali hemmatti,

Homeira Hatami¹,

Hatam Ahmadi²

1Department of Animal Biology, Faculty of Natural Sciences, Tabriz University, Tabriz, Iran.

2Department of Basic Sciences, Farhangian University, Tehran, Iran.

Journal of Inflammatory Diseases:Vol. 23, issue 3; 190-201

Article type:Research Article

How to Cite:Zahedeh Rhimluoye MarjanAlireza ali hemmattiHomeira HatamiHatam AhmadiThe Effect of NO System on Ethidium Bromide-Induced Oxidative Stress in the Hippocampal Formation of Male Rats.J Inflamm Dis.23(3):e156161.

Abstract

Background Acute and chronic effects of nitric oxide on oxidative stress and neuronal demyelination have been reported in human and animal models. Objective Oxidative stress is involved in the pathogenesis of demyelinated animals; thus, this study investigated the effects of nitric oxide system and ethidium bromide on oxidative stress in the hippocampal formation. Methods This experimental study was performed on eight groups of male rats, as follows: control, control, ethidium bromide, L-Arginine, L-NAME, ethidium bromide + L-Arginine, ethidium bromide + L-NAME, and ethidium bromide + L-Arginine + L - NAME. Three days after the injection of drugs into the hippocampal CA1 area, hippocampal biopsy was performed, and oxidative stress parameters were measured in this area. One-way analysis of variance (ANOVA) and posthoc tests were used for data analysis. Findings Injection of 3 μL ethidium bromide into the CA1 region increased oxidative stress parameters (P

Keywords

Ethidium bromide

Nitric oxide

Oxidative stress

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