Medicinal Plants with Abortifacient or Emmenagogue Activity: A Narrative Review Based on Traditional Persian Medicine


avatar Fatemeh Nejatbakhsh 1 , avatar Zahra Aghababaei 2 , avatar Mahboobeh Shirazi 3 , avatar Mohammad Mazaheri 4 , * , avatar Marjan Ghaemi ORCID 5

Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Science, Tehran, Iran
Department of Persian Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran
Isfahan University of Medical Sciences, Isfahan, Iran
Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran

how to cite: Nejatbakhsh F, Aghababaei Z, Shirazi M, Mazaheri M, Ghaemi M. Medicinal Plants with Abortifacient or Emmenagogue Activity: A Narrative Review Based on Traditional Persian Medicine. Jundishapur J Nat Pharm Prod. 2022;17(2):e119559. doi: 10.5812/jjnpp.119559.



Traditional Persian medicine (TPM) has a rich background and has introduced various plants with abortive or emmenagogue activity since ancient times. However, many of them are unknown in modern medicine, and a few trials have been conducted describing their efficacy and safety. These plants may be helpful for the management of incomplete abortion, with potentially lower side effects than chemical agents. This review introduced these plants and their potential efficiency to link traditional and modern medicine and suggested further studies.

Evidence Acquisition:

The search strategy for citations in this narrative review was performed in two steps. At first, medicinal plants used as abortifacient or emmenagogue to manage incomplete abortions or retained products of conception were searched and extracted in the most famous TPM literature, including Al-Qanun Fi at-Tibb, Tuhfat-al-Momenin, and Makhzan-ul-advia. The next step was searching electronic databases including PubMed, Scopus, Web of Science, and Google Scholar with the same keywords and herbal plants between 1970 and 2021. The overlapped plants between the manual and electronic search were found and briefly described.


In TPM literature, 88 plants with abortifacient activity were found, of which 47 were used to manage incomplete abortions or retained products of conception. Also, in the electronic database search, 14 plants were found to have abortifacient or emmenagogue activity. Among them, six plants, including Sesamum indicum L. (Sesame), Commiphora myrrha (myrrh), Lawsonia inermis L. (Henna), Opopanax chironium L. (Jooshir), Plumbago rosea (Shitraj or Stumbag), and Juniperus sabina (Abhal), overlapped with the manual search results. The abortifacient or emmenagogue activity and properties of all these 14 plants were described.


The properties of many traditional plants with abortifacient activity are unknown in modern medicine; however, they should not be used in pregnant women. Nonetheless, they may have the power to be entered into modern medicine. Identifying their pharmacology and action mechanisms may be helpful to introduce them as a potential alternative to chemical agents in the management of induced or incomplete abortion with possibly lower side effects.

1. Context

According to the World Health Organization, three out of 10 pregnancies end in induced abortion, and nearly 40 - 50 million abortions occur annually. Therefore, access to legal, safe, and comprehensive abortion care is essential for achieving the highest possible level of reproductive health (1). Induced abortions occur in all societies regardless of medical, socioeconomic, and religious status (2). In countries with restricted rules for induced abortion, women may be forced to have an illegal abortion that is harmful, particularly for young, poor, and low educated ones (3), possibly leading to maternal mortality (4). Indeed, there is a possibility that the placental and/or fetal tissue remains in the uterus after abortion, which is called incomplete abortion, and the remained tissue stands for the retained products of conception (RPOC) (5) that may cause prolonged vaginal bleeding, endometritis, and occasionally intrauterine adhesions and impairment of future fertility.

Nowadays, early pregnancy termination can be managed medically with misoprostol and/or mifepristone because they are low-cost alternatives to surgery and have higher than 80% of success and great satisfaction (6). However, they have some side effects: bloating, nausea, diarrhea, abdominal cramps, and headaches (7). Moreover, in some instances, such as high doses of the drug, a history of cesarean section, or uterine surgery, it can lead to uterine rupture (8). Therefore, special attention has been paid to traditional medicine as an alternative for chemical agents.

Medicinal plants have been commonly used in Iran and other traditional countries from the distant past (9). Recognizing the plants for inducing abortion and expulsion of retained products of conception can reduce the medical and surgical side effects of abortion. On the other hand, it may enhance the awareness and understanding of the toxic effects of these drugs, which prevent their improper or unknowing use during pregnancy (10). At the same time, most pregnant women assume that herbal medicine does not interfere with fetal and maternal action, but it may cause specific fetal and maternal side effects or drug interactions (11).

Traditional Persian medicine (TPM) has a rich clinical experimental background, which has been passed down orally and in written forms. The present study aimed to overview the medicinal plants used to induce abortion or manage incomplete abortion based on the review of traditional Persian textbooks and evidence of such plants in the electronic databases to find their effects, potential mechanism, and side effects. This may help us propose clinical trials to investigate the safety and efficacy of these drugs in abortion.

2. Evidence Acquisition

2.1. Manual Search

In this review, the most authoritative and well-known textbooks of Persian traditional medicine from the ninth to 18th century were investigated, such as Al-Qanun Fi at-Tibb (The Canon of Medicine) written by Ibn-e-Sina in 1025 Common Era (CE), Tuhfat-al-Momenin written by Mohammad Tonekaboni in 1670 CE, and Makhzan-ul-advia (Storehouse of Medicaments) written by Aghili Khorasani in 1771 CE (12-14). An essential search keyword was medicinal plants with abortifacient activity, which was equal to the Arabic term "mosqete janin." Other keywords, such as inducing menstruation, were also considered, equivalent to "modere heiz." After identifying the plants, their generic names were extracted from popular medicinal plants of Iran and rechecked in Google to confirm the accuracy.

2.2. Electronic Search

In the next step, electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar were searched between January 1970 and April 2021. The main search keywords were "induced abortion" or "emmenagogue" and "herbal plants" in the title and abstract. In this search strategy, the articles in non-English languages were excluded.

Nonetheless, the overlapped plants between hand search and electronic search were briefly reviewed, and the scientific names of the plants, plant families, plants extracts, and active components and their efficacy and safety in animal and human studies were described.

3. Results

Totally 88 plants with abortifacient and emmenagogue activity were identified by the review of the traditional Persian medicine textbooks, 47 of which were helpful in the management of incomplete abortion or retained products of conception. They are categorized as abortifacients, emmenagogues, fetus extractors, and placenta extractors in Table 1.

Table 1. Abortifacient and Emmenagogue Plants in Persian Medicine and Their Potential for Extracting Conception Products
No.Traditional/Local NameScientific NameFamilyActivity
Placenta ExtractorEmmenagogueFetus ExtractorAbortifacient
1TurmusLupinus albusFabaceae
2Otroj/BaalangCitrus medica cedrataRutaceae
3Atrial /GhazyaghiCochlearia coronopus L.Brassicaceae
4AbhalJuniperus sabinaCupressaceae
5ShonizNigella sativa L. Ranunculaceae
6AzarbuLeontice leontopetalum L. Berberidaceae
7Azarion/Hamishe-BaharCalendula officinalis L. Asteraceae
8Oroz/BerenjOryza sativa L. Poaceae
9OshnanSalicornia europaeaAmaranthaceae
10Asabe-sofr/ZardchoobeCurcuma longa L. Zingiberaceae
11Ogh’hovanTanacetum partheniumAsteraceae
12AnzarootAstragalus fasciculifolius Bioss Fabaceae
13AfsantinArtemisia absinthium L. Asteraceae
14Imar-anootaliVerbena supina L. Verbenaceae
15BarzadFerula gummosa Boiss Apiaceae
16ArtanisaCyclamen purpurascens Miller Primulaceae
17Bakhur-al-akradPeucedanum officinale L. Apiaceae
18JawshirOpopanax chironium L. Apiaceae
19Jaavars/ArzanPanicum miliaceum L. Poaceae
20JasjasPulicaria crispa Cass. Asteraceae
21Joze-al-sherkAframomum granum-paradisi K. Schum Zingiberaceae
22HanzalCitrullus colocynthisCucurbitaceaeFetus killer
23Hemmas /NokhodCicer arietinum L. Fabaceae
24Khass /KahooLactuca sativaAsteraceae
25HennaLawsonia inermis L. Lythraceae
26DarciniCinnamomum aromaticum Nees. Lauraceae
27DarfelfelLongum piperPiperaceae
28Zabib-al-jabal /MavizakDelphinium staphisagria L. Ranunculaceae
29DoghosAthamanta cretensis L. Apiaceae
30SarakhsDryopteris filix-mas L. Dryopteridaceae
31Samsam /KonjedSesamum indicum L. Pedaliaceae
32SodabRuta graveolens L. Rutaceae
33Sharife /KajAnnona squamosa L. Annonaceae
34BumadaranAchillea millefoliumAsteraceae
35ShitarajPlumbago rosea L. Plumbaginaceae
36ZayyanJasminum arborescens Roxb. Oleaceae
37GhaarLaurus nobilis L. Lauraceae
38GentianaGentiana lutea L. Gentianaceae
39KarafsApium graveolens L. Apiaceae
40PhotrasaliyounCarum petroselinumApiaceae
41KomaphytusAjuga chamaepitysLamiaceae
42LoofArum italicumAraceae
43Foodanaj /PoonehMentha longifolia L. LamiaceaeFetus killer
44NarjesNarcissus tazetta L. Amaryllidaceae
45HoofarighoonHypericum perforatumHypericaceae
46Baboonaj/BaboonehMatricaria chamomillaAsteraceae
47Saatar/Avishan-ShiraziZataria multiflora Boiss Lamiaceae
48AslaghVitex agnus-castusLamiaceae
49Ratbe /YonjeMedicago sativaFabaceae
50Marmazad/Chay-kouhiStachys lavandulifoliaLamiaceae
51Halyoun/MarchoobeAsparagus officinalisAsparagaceae
52Hendeba/CasniiCichorium intybusAsteraceae
53MarzanjooshOriganum vulgareLamiaceae
54Bad-avardCarduus benedictusAsteraceae
55DarshishaanCalicotome spinosaFabaceae
56KornobBrassica oleracea L. Brassicaceae
57MorrCommiphora myrrhaBurseraceae
58MoshketaramashieMentha aquatica L. Lamiaceae
59Abu khalsaArnebia euchromaBoraginaceae
60ArmaninSalvia viridis L. Lamiaceae
61OshaghDorema ammoniacumApiaceae
62Tin /AnjirFicus carica L. Moraceae
63Jazar /HavijDaucus carota L. Apiaceae
64HashaCoridothymus capitatusLamiaceae
65KheiriCheiranthus cheiri L./Erysimum cheiri L. Brassicaceae
66SaghmooniaConvolvulus scammoniaConvolvulaceaeFetus killer
67SalikhehCinnamomum inersLauraceae
68TarraghiyounPimpinella trgium L. Apiaceae
69FarasiyounMarrubium vulgare L. Lamiaceae
70GhostCostus speciosusCostaceae
71FelfelPiper nigrum L. Piperaceae
72Ghantoriyoun-kabirCentaurea centaurium L. Asteraceae
73Ghantoriyoun-saghirCentaurium minus L. Centaurium erythraeaGentianaceae
74GhaysoomArtemisia vulgaris L. Asteraceae
75Kashem/Anjedan roomi/GolparHeracleum persicumApiaceae
76KondoshVeratrum album L. Melanthiaceae
77LadanCistus villosus L. Cistaceae
78Loze-al-morr/Badam-TalkhAmygdalus amara (C.F.Ludw.) Hayne Rosaceae
79LoobiaPhaseolus vulgaris L. Fabaceae
80FovvahRubia tinctorum L. Rubiaceae
81Kherva /KarchakRicinus communis L. Euphorbiaceae
82ParsiavoshanAdiantum capillus-venerisPteridaceae
83AnisoonPimpinella anisum L. Apiaceae
84Sowm/Seer/GarlicAllium sativumAmaryllidaceae
85HolbehTrigonella foenum-graecum L. Fabaceae
86FolusCassia fistulaFabaceaeFacilitation of delivery
87Zaafaran/SaffronCrocus sativusIridaceaeFacilitation of delivery
88Harmal/EsfandPeganum harmalaNitrariaceaeFetus killer

After removing duplicated studies in electronic search, the search of the electronic databases found 14 plants with abortifacient or emmenagogue activity. Of them, six plants, including Sesamum indicum L. (Sesame), Commiphora myrrha (myrrh), Lawsonia inermis L. (Henna), Opopanax chironium L. (Jooshir), Plumbago rosea (Shitraj or Stumbag), and Juniperus sabina (Abhal), were also found in the manual search. The abortifacient or emmenagogue activity and other properties of all 14 plants are described in the following.

3.1. Heracleum persicum

Heracleum persicum is a flowering plant of the Apiaceae family. This plant grows in Iran, Iraq, and Turkey (15). It is known as “Golpar” in Iran (16). Various natural chemicals such as volatile (terpenes, aliphatic esters, phenyl propenes, and carbonyls) and non-volatile (furanocoumarins, alkaloids, flavonoids, and tannins) constituents and several minerals were identified during phytochemical analysis (16). Dried fruits are used as contraceptive, lactagogue, emmenagogue, and pain killer agents. A study showed that H. persicum L. is teratogenic with abortifacient activity in mice (17). Therefore, it should be taken with caution during pregnancy.

3.2. Origanum vulgare

Origanum vulgare L. (Marzanjosh) is an important medicinal herb of the Lamiaceae family. Origanum vulgare was traditionally used to treat dysmenorrhea (18). The active chemicals are volatile (essential oil) and non-volatile phenolic compounds (phenolic acids and flavonoids). Others biologically active compounds are terpenoids, tannins, and sterols (19). It has been shown that high dosages of O. vulgare extract can increase the rate of abortion and fetal malformations in the fetus of mice (20).

3.3. Zataria multiflora Boiss

Zataria multiflora Boiss (Shirazi thyme) is an aromatic perennial shrub from the Lamiaceae family, which is native to Iran, Afghanistan, and Pakistan. It is full of phytochemical components and biological activities. Zataria multiflora is called "Avishane Shirazi" in Persian and is used as a seasoned flour in many foods in Iran. The chemical components of Z. multiflora include β-sitosterol, luteolin, apigenin, linalool, 6-hydroxyluteolin, thymol, carvacrol, γ-terpinene, and p-cymene (21). Zataria multiflora is effective in the treatment of primary dysmenorrhea (22). It is enriched by gamma-terpinene that may damage DNA (23, 24). However, thyme consumption in early pregnancy may lead to abortion due to its adverse effects on the placental diameter. Therefore, its use would be with caution during pregnancy (25).

3.4. Sesamum indicum L.

Sesamum indicum L. is from the Pedaliaceae family. It has been well known for over 5,000 years as an oilseed crop. Sesamum indicum L. is widely used in traditional medicine as oily seeds with emmenagogue activity (26) and facilitated delivery (27). Also, in the cases of oligomenorrhea with menstruation retard for more than two weeks, it may be an effective choice in inducing menstruation with ignorable side effects compared to hormonal therapies (28). In a clinical trial by Aghababaei et al., Sesame was efficient for removing retained products of conception with minor vaginal bleeding and pain than the control group (29).

3.5. Commiphora myrrha

Commiphora myrrha (Nees.) Engl. is a large shrub or small tree belonging to Sapindales, a family of Burseraceae and genus Commiphora, found in abundance in northeast Africa and the Middle East (30). Preliminary research has indicated that myrrh contained about 3 - 8% essential oil, 25 - 40% resins, and 30 - 60% water-soluble gum. It contains several bioactive metabolites such as flavonoids, terpenoids, steroids, lignans, carbohydrates, and long-chain aliphatic alcohol derivatives (31). It is a uterine stimulant with emmenagogue activity (32). Vafaei et al. assessed the efficacy of myrrh in patients with incomplete abortion. Meanwhile, the rate of successful complete abortion was 82.9% compared with 54.3% in the placebo group that was significantly different (33).

3.6. Stachys lavandulifolia

Stachys lavandulifolia belongs to the Lamiaceae family and grows worldwide, although it is endemic in Iran. They are well known for their flavoring and therapeutic effects. It contains hydroxyl and phenolic compounds such as polyphenols, tannins, steroids, flavonoids, and terpenoids (34). Due to the presence of flavonoid compounds, it changes the function level of the hypothalamic-pituitary-gonadal axis. This plant can reduce the progesterone level by more than 20%; therefore, it leads to miscarriage and inability to preserve the fetus and risk of abortion depending on dosage in animals (35). Abortion can be caused by the use of S. lavandulifolia during pregnancy; therefore, it should be considered a contraindication or used with caution (35). Also, it is used to control premenstrual syndrome (PMS) and primary dysmenorrhea symptoms (36) and can be suggested as add-on therapy or even an alternative remedy to non-steroidal anti-inflammatory drugs (NSAIDs) with fewer side effects (37).

3.7. Peganum harmala

Peganum harmala L. from the Zygophyllaceae family is well-known for its seeds, root, and bark in traditional Persian medicine and is known as "Esfand," "Espand," and "Harmal" in Iran. The pharmacological and therapeutic effects of P. harmala are mainly from alkaloids (38-40).

An in-vivo study found that the hydroalcoholic extract of P. harmala had contractive effects on the uterus and stripped the myometrium via the external calcium flow by the voltage-dependent calcium channels (41). Quinazoline alkaloids vasicine and vasicinone have been attributed to the abortifacient activity (42, 43). Therefore, it is contraindicated during pregnancy (40).

3.8. Ruta graveolens L.

Ruta graveolens belonging to the Rutaceae family is an ever-green shrub distributed worldwide (44). Some of its chemical constituents are glycosides (flavonoids) and alkaloids (quinolones: coquisagenine, skimmianine, and graveoline) (45). Dried aerial parts of R. graveolens induce abortion through the mechanism of multiple organ damage and death. There is no estrogenic effect; however, it can interfere with implantation time (46). The aqueous extract interferes with the pre-implantation phase in mice (47).

In a study examining the abortion and estrogenic activity of ethanolic extract of Sodab on different days of pregnancy in female rats, abortion or stillbirth was not observed on one to six days, but fetal malformation was observed after use on 7 - 9 days of gestation (47). Besides, DNA replication and mitosis can also be prevented by Psoralens in Sodab (R. graveolens L.) (47). The alkaloids in the plant can reduce the number of fetal cells and decrease the transmission of fetuses from the oviduct to the uterine branches.

3.9. Crocus sativus

In Persian medicine, C. sativus, known as Saffron, has a hard, circular, meaty onion covered with thin, brown membranes (48). It contains several active and potent biological compounds, including crocin and croctin as the most active ones. An experimental study by Hosseini et al. (49) assessed the abortifacient and teratogenic effects of different doses of C. sativus in female mice. Their results showed that the numbers of resorbed and demised fetuses were more significant than in the control group. Saffron may affect embryonic implantation that results in abortion.

Indeed, high doses of Saffron may interfere with organogenesis that mostly happens in the second gestational trimester and leads to abnormalities such as decreased tail length and placenta weight and diameter in animal studies (49).

Tafazoli et al. evaluated the effect of Saffron on abortion and its side effects on BALB/c mice and indicated that the percentages of absorbed and abnormal embryos increased significantly in the Saffron group (50). In a prospective case-control study on pregnant female farmers during the harvesting season of Saffron, the abortion rate was significantly higher among female farmers who had Saffron exposure (51). In a clinical study, Darooneh et al. investigated the effect of C. sativus (Saffron) on cervical ripening and the progress of labor in primiparous women. Their results showed that Saffron could shorten the average length of the first and second labor stages and induce stimulation and intensification of uterine contractions, labor facilitation, and lower oxytocin use (52).

3.10. Opoponax chironium

The genus O. chironium is a member of the Apiaceae family and grows in the Mediterranean. It is yellow and consumed as food and medicine. It contains abortifacient activity, and its mixture with honey is used as a vaginal suppository, which is very effective as feticide and for expelling the product of conception (53).

3.11. Lowsonia inermis

Lowsonia inermis is known as Henna in Persian medicine (54). This plant contains quinones, phenylpropanoids, flavonoids, terpenoids, phenolic compounds, and fatty acids. Apigenin is a flavonoid that exists in aromatic vegetables like Henna. Lowsonia inermis may be teratogen and should be used cautiously during pregnancy (55). Jafarzadeh et al. investigated the teratogenicity of this plant, showing that the L. inermis plant could create abnormalities in mice, and its teratogenic effects were dose-dependent (56). Also, Esteki and Miraj investigated the abortifacient effects of hydroalcoholic extract of L. inermis on female mice. Their results showed that L. inermis could significantly increase estrogen and decrease progesterone levels; besides, induced abortion was significantly lower in the experimental groups (57).

3.12. Plumbago rosea

Plumbago rosea L., mostly known as Rakta Chitrak, is mainly growing in the wild and abundantly in India. Quinones, polyphenols, alkaloids, and flavonoids are the significant phytochemicals reported from the plant. Plumbagin, hydroxy-1, 4-napthaquinone, sitosterol glycoside, fatty alcohol, and tannins are the active constituents in this plant. Sheeja et al. worked on the antifertility activity of P. rosea stem in female albino rats using different solvent extracts like petroleum ether, chloroform, acetone, and ethanol, confirming the significant estrogenic and anti-estrogenic activity of acetone extracts (58).

The plant's roots possess anti-tumor, anti-teratogenicity, anti-fertility, and uterine activities (59). The extracts of this plant can be further explored for contraceptive use (59). The possible presence of the utero-active compound in this plant was indicated by inhibiting oxytocic agents causing uterine motility. Furthermore, unwanted pregnancy can be avoided by supporting the accredited traditional use of pronounced fetotoxic and mild abortifacient potentials observed at higher doses in pregnant mice (60).

3.13. Juniperus sabina

Juniperus sabina is called Abhal in Arabic and Savin in English. This plant is one of the plants used for abortion in the past (61). Its extract or infusion is used as a medicine to increase menstruation. In Persian medicine, its essential oil and extract are used for their abortive and laxative qualities (62). It also contains lignans such as deoxypodophyllotoxin and terpene. The major components of the terpene part include sabinyl acetate and Sabinene. Sabinyl acetate is a terpenoid compound, comprising about 50% of this plant and accounting for its abortive and presumably poisonous qualities.

Oils rich in sabinyl acetate are considered dangerous (63). The abortive qualities are generally attributed to essential oils, particularly sabinyl acetate, which effectively prevents implantation. A study conducted by Mortazavi Gazar et al. assessed the effects of alcoholic extracts of J. sabina on oogenesis in mice. They showed that J. sabina could cause corpus luteum and atrophic follicles to increase and Graafian follicle and primary follicle to decrease, which can have undesirable effects on implantation and the number and size of the ovum (61).

3.14. Matricaria chamomilla

Chamomile is from the Asteraceae family, the primary source of which is the Mediterranean, but nowadays, it is widespread in Europe, the temperate regions of Asia, and even the United States (64). Their flowers include multiple phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin, luteolin, and their glucosides terpenoids α-bisabolol and its oxides and azulenes, including chamazulene.

In an experimental study, Mirzakhani assessed the abortive effect of this plant in 80 adult female rats and showed a significant increase in the number of aborted fetuses and follicle atresia and decreases in the serum levels of estrogen, progesterone, luteinizing hormone (LH), and follicular stimulation hormone (FSH) (65). It also causes uterine contraction invoking miscarriage in pregnant women and decreasing the labor pain intensity (66). The abortifacient medicinal plants that overlap in traditional and modern medicine are listed in Table 2.

Table 2. Abortifacient Medicinal Plants Overlapping Between Traditional and Modern Medicine
No.Scientific NameFamilyStudy Type (Animal or Human)Study ResultsActive IngredientsReference
1Heracleum persicumUmbelliferaeMiceIncreasing estrogen and reducing progesterone by abortion induction(18)
2Origanum vulgareLamiaceaeMiceIncreasing fetal abnormalities and inducing abortion(19)
3Zataria multiflora Boiss LamiaceaeMiceLack of abortion-reducing the diameter of the pair(20)
4Sesamum indicumHuman (clinical trial)Hot water extract
5Commiphora myrrhaHuman (clinical trial)
6Stachys lavandulifloraLamiaceaeMiceAbortive effects(18)
7Peganum harmalaNitrariaceaeMice
8Ruta graveolens L. RutaceaeLibrary studyEffective on the reproductive system, especially in men; its effect on abortion induction has not been proven; influencing infertility(22, 23)
Experimental-miceNo effect on the fetusEdible extract(24)
Experimental-hamsterNo effect on the fetus and fertility processEdible extract and powder from root mil(25)
9Crocus sativusIridaceaeMiceEffect on abortion and preterm childbirth(26, 27)
Experimental-miceStrong abortiveAqueous extract(28)
Descriptive-analytical humanAbortiveContact or long proximity to saffron(29)
Experimental-miceNo effect on the fetusEdible extract(30)
10Opoponax ferula galbanifulasApiaceae
11Lawsonia inermisLythraceaeMiceIncreasing fetal abnormalities(32)
Experimental-miceAbortiveAqueous-alcoholic extract(33)
12Plumbago roseaPlumbaginaceaeExperimental miceAbortiveAlcoholic extract of the root(34)
13Juniperus sabina L. Cupressaceae
14Matricaria chamomilla L. AsteraceaeExperimental-miceImpact on abortionBloom extract(35)
Clinical trial-humanAbortiveAqueous-alcoholic extract(36)

4. Discussion

Traditional medicinal plants have been considered a reliable resource for healing in local communities worldwide for thousands of years, and more than three-quarters of the world population trust traditional herbal medicine for health care. There is an increasing interest in traditional herbal remedies due to their safety, efficacy, cost-effectiveness, eco-friendliness, ready availability, cultural acceptability, and fewer side effects than synthetic drugs (67). They are also the source of drug discovery and may even be considered the origin of modern medicine (68).

According to the WHO report, women comprise a group with the most frequent use in complementary and alternative medicine therapy (69). During pregnancy, especially in developing countries, women tend to self-medication with herbs as natural and safe substances. However, the lack of knowledge of side effects and the interactions of herbal medicines with chemical drugs may cause carcinogenic or toxic compounds in the body (61).

This study tried to assemble the available evidence about the effect of medicinal plants on abortion in Persian and conventional medicine references (12, 13), with different mechanisms including estrogenic activity, increased menstrual flow, induced abortion, uterine stimulation, increased bleeding risk, uterine contraction, uterotrophic activity, and stimulant action on uterine muscles (70). Some medicinal plants with abortive effects introduced in Persian medicine can decrease progesterone levels, such as M. chamomilla (57, 65). Progesterone is a critical hormone in early pregnancy. A low serum progesterone level is associated with threatened miscarriage (71).

Minimal human studies have been done, primarily in-vitro or in-vivo. Two clinical trials assessed the effects of medicinal plants (S. indicum L. (Sesame) and C. myrrha) on incomplete abortion management. Both studies showed that these plants are effective (29, 33). A prospective case-control study found that the miscarriage rate was significantly higher among female farmers with Saffron exposure (51).

The present study showed that some studied plants are emmenagogue (eg, M. chamomilla, Z. multiflora, and S. lavandulifolia) or delivery facilitator (not abortifacient, eg, C. sativus (Saffron)) (12, 13). Many of these plants are present in the daily diet, including Cicer arietinum L. (Hemmas, Nokhod), Phaseolus vulgaris L. (lubya), rice bran (first or outer skin of rice), Oryza sativa L. (oroz, Berenj), L. albus, Cinnamomum aromaticum Nees., Apium graveolens L., S. indicum L. (Konjed), Daucus caruta L., Piper nigrum L.

Studies on the abortifacient activity of some plants, such as C. sativus, revealed controversial results at different doses (49). Our findings revealed that the abortifacient activity of L. inermis L. (Henna), J. sabina (Abel or Abhal), and S. indicum L. (Konjed) had been proven in both traditional medicine and recent studies (29, 57, 61).

Studies carried out on P. harmala have shown that the consumption of this plant interrupts fetal growth, and it is an abortifacient plant (43). In Persian medicine, P. harmala is also used as feticide (12, 13). Crocus sativus agents share common effects on cell division and DNA cycles, leading to abortion. The impact of C. sativus on abortion is more approved, while in Persian traditional medicine, it is used as a placenta extractor and a delivery facilitator (12, 13). Also, R. graveolens L. has no abortion induction effect (47), while in Persian medicine texts, it is also known as an abortifacient to menstruation and emmenagogue (12-14).

Based on traditional medicine contexts, even though pineapple does not affect pregnancy, embryos, and abortion, recent studies have proven these effects (72). Anchusa italic has an abortive effect, while there is nothing mentioned in Persian medicine contexts in this regard (73). Some of the plants studied in new medicine are not effective or have poor effects, which can be related to factors such as part of the plant used (leaf, root, etc.), preparation method (aqueous, water extract, alcoholic, etc.), or medication rout of use (oral, topical, suppository, or water).

The present study results can be used as an outline for future studies about effective plants in conventional and complementary medicine. Further studies are needed to understand better the effects of medicinal plants on incomplete abortion management. Further pharmacological and clinical studies are recommended to evaluate the efficacy of all Persian medicine plants in abortion and their possible action mechanisms. Plants such as Citrus medica cedrata, Mentha longifolia L., Achillea millefolium, Carum petroselinum, Narcissus tazzeta L., Hypericum perforatum L., Cheiranthus cheiri L., Arum italicum L., Rubia tinctorum L., Ferula gummosa Boiss, Nigella sativa L. (Shoniz), and L. albus have three or four effects and high potency and frequency in Persian medicine (12, 13). Therefore, using these herbs in future clinical studies is proposed for incomplete abortion management.

4.1. Conclusions

The abortifacient activity of L. inermis L. (Henna), O. chironium L. (Jooshir), P. rosea (Stumbag, Shitraj), and J. sabina (Abel or Abhal) have been proven in both traditional medicine and recent studies. The properties of many traditional plants with abortifacient activity are unknown in modern medicine; however, they should not be used in pregnant women. However, it may have the power to be entered into modern medicine. Identifying the pharmacology and their action mechanisms may be helpful to introduce them as a potential alternative for chemical agents in the management of induced or incomplete abortion with possibly lower side effects.



  • 1.

    World Health Organizaion. Abortion. World Health Organizaion; 2021, [cited 21/1/1]. Available from:

  • 2.

    Cuellar Torriente M, Joubert G, Steinberg W. Contraceptive Use and Reasons for Termination of Pregnancy Among Women Attending a Reproductive Health Clinic at a District Hospital, Free State, South Africa. Afr J Nurs Midwifery. 2016;18(2):119-31.

  • 3.

    Grimes DA, Benson J, Singh S, Romero M, Ganatra B, Okonofua FE, et al. Unsafe abortion: the preventable pandemic. Lancet. 2006;368(9550):1908-19. doi: 10.1016/s0140-6736(06)69481-6.

  • 4.

    Rehnstrom Loi U, Gemzell-Danielsson K, Faxelid E, Klingberg-Allvin M. Health care providers' perceptions of and attitudes towards induced abortions in sub-Saharan Africa and Southeast Asia: a systematic literature review of qualitative and quantitative data. BMC Public Health. 2015;15:139. doi: 10.1186/s12889-015-1502-2. [PubMed: 25886459]. [PubMed Central: PMC4335425].

  • 5.

    Redinger A, Nguyen H. Incomplete Abortions. Florida, USA: StatPearls; 2021.

  • 6.

    Cubo AM, Soto ZM, Haro-Perez A, Hernandez Hernandez ME, Doyague MJ, Sayagues JM. Medical versus surgical treatment of first trimester spontaneous abortion: A cost-minimization analysis. PLoS One. 2019;14(1). e0210449. doi: 10.1371/journal.pone.0210449. [PubMed: 30629715]. [PubMed Central: PMC6328124].

  • 7.

    Elul B, Ellertson C, Winikoff B, Coyaji K. Side effects of mifepristone-misoprostol abortion versus surgical abortion. Contraception. 1999;59(2):107-14. doi: 10.1016/s0010-7824(99)00003-7.

  • 8.

    Hammer A, Bannason J, Lauszus FF. Second trimester rupture in a retroflexed, scarred uterus. J Obstet Gynaecol. 2013;33(6):629-30. doi: 10.3109/01443615.2013.795135. [PubMed: 23919868].

  • 9.

    Sewell RD, Rafieian-Kopaei M. The history and ups and downs of herbal medicines usage. J HerbMed Pharmacol. 2014;3.

  • 10.

    Graul AI, Sorbera L, Pina P, Tell M, Cruces E, Rosa E, et al. The Year's New Drugs & Biologics - 2009. Drug News Perspect. 2010;23(1):7-36. doi: 10.1358/dnp.2010.23.1.1440373. [PubMed: 20155217].

  • 11.

    Oduyebo T, Petersen EE, Rasmussen SA, Mead PS, Meaney-Delman D, Renquist CM, et al. Update: Interim Guidelines for Health Care Providers Caring for Pregnant Women and Women of Reproductive Age with Possible Zika Virus Exposure - United States, 2016. Morb Mortal Wkly Rep. 2016;65(5):122-7. doi: 10.15585/mmwr.mm6505e2. [PubMed: 26866840].

  • 12.

    Ibn-e-Sina. [The Canon of Medicine]. Soroush Press; 2005. Arabic.

  • 13.

    Aghili Khorasani M. [Storehouse of Medicaments]. Tehran, Iran: Tehran University Publication; 1771. Persian.

  • 14.

    Tonekaboni SMM. [Tuhfat-al-Momenin]. Qom, Iran: Noore Vahy; 2011. Arabic.

  • 15.

    Jonsell BK. Heracleum persicum (Persian hogweed). Sweden. 2020.

  • 16.

    Majidi Z, Sadati Lamardi SN. Phytochemistry and biological activities of Heracleum persicum: a review. J Integr Med. 2018;16(4):223-35. doi: 10.1016/j.joim.2018.05.004. [PubMed: 29866612].

  • 17.

    Jafarzadeh L, Sedighi M, Behzadian M, Ansari Samani R, Shahinfard N, Rafieian-Kopaei M. [The teratogenic and abortifacient effects of heracleum persicum hydroalcholic extract and its correlation with mothers’ estrogen and progesterone in Balb/C mice]. J Babol Univ Med Sci. 2014;16(3):26-32. Persian.

  • 18.

    Lukas B, Schmiderer C, Mitteregger U, Novak J. Arbutin in marjoram and oregano. Food Chemistry. 2010;121(1):185-90. doi: 10.1016/j.foodchem.2009.12.028.

  • 19.

    Morshedloo MR, Craker LE, Salami A, Nazeri V, Sang H, Maggi F. Effect of prolonged water stress on essential oil content, compositions and gene expression patterns of mono- and sesquiterpene synthesis in two oregano (Origanum vulgare L.) subspecies. Plant Physiol Biochem. 2017;111:119-28. doi: 10.1016/j.plaphy.2016.11.023. [PubMed: 27915173].

  • 20.

    Kashani IR, Ansari M, Mehrannia K, Moazzemi K, Joybary SV. [Teratogenic effects of Origanum Vulgare extract in mice fetals]. Tehran Univ Med J. 2013;71(8). Persian.

  • 21.

    Kavoosi G, Rabiei F. Zataria multiflora: chemical and biological diversity in the essential oil. J Essent Oil Res. 2015;27(5):428-36. doi: 10.1080/10412905.2015.1031917.

  • 22.

    Afshari Fard MR, Mohammadi A, Ma LX, Mu JD, Yu WY, Song Y, et al. Comparison of the immediate analgesic effect of perpendicular needling and transverse needling at SP6 in patients with primary dysmenorrhea: Study protocol for a randomized controlled trial. Medicine (Baltimore). 2020;99(3). e18847. doi: 10.1097/MD.0000000000018847. [PubMed: 32011502]. [PubMed Central: PMC7220365].

  • 23.

    Aydin S, Basaran AA, Basaran N. The effects of thyme volatiles on the induction of DNA damage by the heterocyclic amine IQ and mitomycin C. Mutat Res. 2005;581(1-2):43-53. doi: 10.1016/j.mrgentox.2004.10.017. [PubMed: 15725604].

  • 24.

    Colas C, Monzon S, Venturini M, Lezaun A. Double-blind, placebo-controlled study with a modified therapeutic vaccine of Salsola kali (Russian thistle) administered through use of a cluster schedule. J Allergy Clin Immunol. 2006;117(4):810-6. doi: 10.1016/j.jaci.2005.11.039. [PubMed: 16630938].

  • 25.

    Anvari M, Dashti MH, Zeinali F, Hosseini-Bioki SM. The effect of thyme (Zataria multiflora Boiss.) decoction on pregnancy in rats. J Med Plants. 2011;10(38):19-25.

  • 26.

    Singh RJ, Jauhar PP. Genetic Resources, Chromosome Engineering, and Crop Improvement: Cereals. Vol. 2. CRC Press; 2006.

  • 27.

    Hamedi A, Zarshenas MM, Sohrabpour M, Zargaran A. Herbal medicinal oils in traditional Persian medicine. Pharm Biol. 2013;51(9):1208-18. doi: 10.3109/13880209.2013.777462. [PubMed: 23746335].

  • 28.

    Yavari M, Rouholamin S, Tansaz M, Bioos S, Esmaeili S. Sesame a Treatment of Menstrual Bleeding Cessation in Iranian Traditional Medicine: Results From a Pilot Study. Shiraz E-Med J. 2014;15(3). doi: 10.17795/semj21893.

  • 29.

    Aghababaei Z, Nejatbakhsh F, Mazaheri M, Shirazi M, Feizi A, Bozorgi M, et al. Efficacy of Sesame (Sesamum indicum L.) in the Management of Incomplete Abortion: An Open-Label Randomized Controlled Clinical Trial. Complement Med Res. 2021;28(6):501-7. doi: 10.1159/000510901. [PubMed: 34192691].

  • 30.

    Hussain H, Al-Harrasi A, Al-Rawahi A, Hussain J. Chemistry and biology of essential oils of genus boswellia. Evid Based Complement Alternat Med. 2013;2013:140509. doi: 10.1155/2013/140509. [PubMed: 23533463]. [PubMed Central: PMC3606720].

  • 31.

    Boual Z, Pierre G, Abdellah K, Mosbah S, Benaoun F, Delattre C. Chemical composition and biological activities of water-soluble polysaccharides from Commiphora myrrha (Nees). Engl Gum. 2020;17:50-5.

  • 32.

    El Ashry ESH, Rashed N, Salama OM, Saleh A. Components, therapeutic value and uses of myrrh. Pharmazie. 2003;58(3):163-8.

  • 33.

    Vafaei H, Ajdari S, Hessami K, Hosseinkhani A, Foroughinia L, Asadi N, et al. Efficacy and safety of myrrh in patients with incomplete abortion: a randomized, double-blind, placebo-controlled clinical study. BMC Complement Med Ther. 2020;20(1):145. doi: 10.1186/s12906-020-02946-z. [PubMed: 32397980]. [PubMed Central: PMC7218551].

  • 34.

    Javidnia K, Mojab F, Mojahedi SA. Chemical constituents of the essential oil of Stachys lavandulifolia Vahl from Iran. Pharmazie. 2010;(1):61-3.

  • 35.

    Jafarzadeh L, Asgari A, Golshan-Iranpoor F, Kheiri S, Parvin N, Rafieian M, et al. [Abortificient effects of Stachys lavandulifolia Vahl in mice]. J Shahrekord Univ Med Sci. 2010;11(4):26-31. Persian.

  • 36.

    Olfati F, Azarbaijani S, Hadizadeh M, Sadeghi T, Hajseiedjavadi E. Effect of powder of Stachys lvandulifolia flowers on primary dysmenorrhea. J Med Plants. 2010;9(34).

  • 37.

    Monji F, Hashemian F, Salehi Surmaghi MH, Mohammadyari F, Ghiyaei S, Soltanmohammadi A. Therapeutic Effects of Standardized Formulation of Stachys lavandulifolia Vahl on Primary Dysmenorrhea: A Randomized, Double-Blind, Crossover, Placebo-Controlled Pilot Study. J Altern Complement Med. 2018;24(11):1092-8. doi: 10.1089/acm.2017.0329. [PubMed: 29741912].

  • 38.

    Chevallier A. Encyclopedia of Herbal Medicine: 550 Herbs and Remedies for Common Ailments. 3rd ed. London, UK: DK Publishing; 2016.

  • 39.

    Frison G, Favretto D, Zancanaro F, Fazzin G, Ferrara SD. A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract. Forensic Sci Int. 2008;179(2-3):e37-43. doi: 10.1016/j.forsciint.2008.05.003. [PubMed: 18603389].

  • 40.

    Niroumand MC, Farzaei MH, Amin G. Medicinal properties of Peganum harmala L. in traditional Iranian medicine and modern phytotherapy: a review. J Tradit Chin Med. 2015;35(1):104-9. doi: 10.1016/s0254-6272(15)30016-9.

  • 41.

    Fathiazad F, Azarmi Y, Khodaie L. Pharmacological effects of Peganum harmala seeds extract on isolated rat uterus. Iran J Pharm Sci. 2006;2(2):81-6.

  • 42.

    Berdai MA, Labib S, Harandou M. Peganum harmala L. Intoxication in a Pregnant Woman. Case Rep Emerg Med. 2014;2014:783236. doi: 10.1155/2014/783236. [PubMed: 24955262]. [PubMed Central: PMC4053228].

  • 43.

    Shapira Z, Terkel J, Egozi Y, Nyska A, Friedman J. Abortifacient potential for the epigeal parts of Peganum harmala. J Ethnopharmacol. 1989;27(3):319-25. doi: 10.1016/0378-8741(89)90006-8.

  • 44.

    Shams Ardakani M. [The storehouse of medicaments]. Tehran, Iran: Tehran University of Medical Sciences; 1992. Persian.

  • 45.

    Lans C, Turner N, Khan T, Brauer G. Ethnoveterinary medicines used to treat endoparasites and stomach problems in pigs and pets in British Columbia, Canada. Vet Parasitol. 2007;148(3-4):325-40. doi: 10.1016/j.vetpar.2007.06.014. [PubMed: 17628343].

  • 46.

    Kováts N, Ács A, Refaey M, Baán ZS. Medical use and toxic properties of rue (Ruta graveolens) and peppermint. University of Pannonia. 2008.

  • 47.

    de Freitas TG, Augusto PM, Montanari T. Effect of Ruta graveolens L. on pregnant mice. Contraception. 2005;71(1):74-7. doi: 10.1016/j.contraception.2004.07.014. [PubMed: 15639078].

  • 48.

    Ghaffari S, Hatami H, Dehghan G. [The effect of ethanolic extract of saffron (Crocus sativus L.) on oxidative stress markers in the hippocampus of experimental models of MS]. Med J Tabriz Univ Med Sci. 2015;37(1):40-9. Persian.

  • 49.

    Hosseini SM, Dashti RMH, Anvari M, Zeinali F. The abortificant effects of different doses of saffron (Crocus sativus) decoction in mice. Planta Medica. 2009;75(9). doi: 10.1055/s-0029-1234792.

  • 50.

    Tafazoli M, Kermani T, Saadatjoo AR. Effects of saffron on abortion and its side effect on mice balb/c. Horiz Med Sci. 2004;10(3):53-5.

  • 51.

    Ajam M, Reyhani T, Roshanravan V, Zare Z. Increased miscarriage rate in female farmers working in saffron fields: a possible effect of saffron toxicity. Asia Pac J Med Toxicol. 2014;3(2):73-5.

  • 52.

    Darooneh T, Ali-Akbari Sichani B, Rashidi Fakari F, Moattar F, Nasiri M, Delpak- Yeganeh S. Effect of Crocus sativus (Saffron) on Cervical Ripening and Progress of Labor in Primiparous Term Women: A Randomized Double-Blind Placebo-Controlled Trial. Int J Pediatr. 2020;8(9):12105-15.

  • 53.

    Mazza D, Burton G, Wilson S, Boulton E, Fairweather J, Black KI. Medical abortion. Aust J Gen Pract. 2020;49(6):324-30. doi: 10.31128/AJGP-02-20-5223. [PubMed: 32464732].

  • 54.

    Gorji A. Pharmacological treatment of headache using traditional Persian medicine. Trends Pharmacol Sci. 2003;24(7):331-4. doi: 10.1016/s0165-6147(03)00164-0.

  • 55.

    Badoni Semwal R, Semwal DK, Combrinck S, Cartwright-Jones C, Viljoen A. Lawsonia inermis L. (henna): ethnobotanical, phytochemical and pharmacological aspects. J Ethnopharmacol. 2014;155(1):80-103. doi: 10.1016/j.jep.2014.05.042. [PubMed: 24886774].

  • 56.

    Jafarzadeh L, Seifi N, Shahinfard N, Sedighi M, Kheiri S, Shirzad H, et al. Antioxidant Activity and Teratogenicity Evaluation of Lawsonia inermis in BALB/c Mice. J Clin Diagn Res. 2015;9(5):FF01-4. doi: 10.7860/JCDR/2015/12290.5911. [PubMed: 26155492]. [PubMed Central: PMC4484084].

  • 57.

    Esteki R, Miraj S. The Abortificient Effects of Hydroalcoholic Extract of Lawsonia inermis on BALB/c Mice. Electron Physician. 2016;8(6):2568-75. doi: 10.19082/2568. [PubMed: 27504174]. [PubMed Central: PMC4965209].

  • 58.

    Sheeja E, Joshi SB, Jain DC. Antifertility Activity of Stems of Plumbago roseain Female Albino Rats. Pharmaceutical Biology. 2009;46(12):920-7. doi: 10.1080/13880200802245203.

  • 59.

    Sheeja E, Joshi SB, Jain DC. Antiovulatory and estrogenic activity of Plumbago rosea leaves in female albino rats. Indian J Pharmacol. 2009;41(6):273-7. doi: 10.4103/0253-7613.59927. [PubMed: 20407559]. [PubMed Central: PMC2846502].

  • 60.

    Abdul Sattar M, Abdullah NA, Khan MA, Dewa A, Samshia D. Uterotrophic, fetotoxic and abortifacient effect of a Malaysian variety of Plumbago rosea L. on isolated rat uterus and pregnant mice. Pak J Biol Sci. 2007;10(5):763-7. doi: 10.3923/pjbs.2007.763.767. [PubMed: 19069860].

  • 61.

    Mortazavi Gazar S, Tafvizi F, Hayati Roodbari N, Yaghmaee P. [Effects of Alcoholic Extracts of Maymarz (Juniperuse sabina) on Oogenesis in Matured NMRI Mouse Strain]. J Rafsanjan Univ Med Sci. 2017;16(3):203-16. Persian.

  • 62.

    Ahmadi K, Omidi H, Amini Dehaghi M, Naghdi Badi H. A Review on the Botanical, Phytochemical and Pharmacological Characteristics of Kelussia odoratissima Mozaff. J Med Plants. 2020;4(72):30-45. doi: 10.29252/jmp.4.72.S12.30.

  • 63.

    Esmaili M, Monfared A, Akbarzadeh M. Chemical composition of hydrodistillation essential oil of fruits and aerial parts of Juniperus sabina L. from Hezar-Jarib in Mazandaran province. J Ethno-Pharmaceutical Prod. 2014.

  • 64.

    Singh O, Khanam Z, Misra N, Srivastava MK. Chamomile (Matricaria chamomilla L.): An overview. Pharmacogn Rev. 2011;5(9):82-95. doi: 10.4103/0973-7847.79103. [PubMed: 22096322]. [PubMed Central: PMC3210003].

  • 65.

    Mirzakhani Z, Hosseini SE. [Effects of chamomile hydro-alcoholic extract (Matricaria chamomilla) on the aborted fetuses, serum sex hormones and ovarian follicles in adult female rats]. J Ardabil Univ Med Sci. 2017;17(1):22-31. Persian.

  • 66.

    Heidarifard S, Fallah S, Akbari SAA, Mojab F. Evaluation of the effects of Matricaria chamomilla aroma on intensity of the labor pain in primparous women in Emdadi Hospital of Abhar in 2013. Int Pharm Acta. 2013;1(1):99-100.

  • 67.

    Akerele O, Heywood V, Synge H. Conservation of medicinal plants. Cambridge University Press; 2010. doi: 10.1017/cbo9780511753312.

  • 68.

    David B, Wolfender J, Dias DA. The pharmaceutical industry and natural products: historical status and new trends. Phytochem Rev. 2014;14(2):299-315. doi: 10.1007/s11101-014-9367-z.

  • 69.

    Bernstein N, Akram M, Yaniv-Bachrach Z, Daniyal M. Is it safe to consume traditional medicinal plants during pregnancy? Phytother Res. 2021;35(4):1908-24. doi: 10.1002/ptr.6935. [PubMed: 33164294].

  • 70.

    Akbarizadeha N, Borhan A, Baqalpour N, Mahroobakhtiari J, Hosseinabadi T. Medicinal Plants with Abortifacient Activity. Int Pharm Acta.

  • 71.

    Di Renzo GC, Giardina I, Clerici G, Brillo E, Gerli S. Progesterone in normal and pathological pregnancy. Horm Mol Biol Clin Investig. 2016;27(1):35-48. doi: 10.1515/hmbci-2016-0038. [PubMed: 27662646].

  • 72.

    Pakrashi A, Basak B. Abortifacient effect of steroids from Ananas comosus and their analogues on mice. J Reprod Fertil. 1976;46(2):461-2. doi: 10.1530/jrf.0.0460461. [PubMed: 943531].

  • 73.

    Zanganeh A, Rozbahani S, Monajemi R. The Effect of Aqueous Extract of Borage (Anchusa Italica) on Abortion in Syrian Mice Female Wistar. J Anim Biol. 2016;8(2).

Copyright © 2022, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.