Abstract
Context:
Preventive care is a basic rule in current medical practice and traditional Persian medicine (TPM) scholars have introduced a large amount of publications in this valued field. According to TPM principles, healthy stomach has a significant role in providing a fit body and herbal medicines are capable of helping stomach perform this role.Evidence Acquisition:
A wide-ranging search in main TPM books and web engines was performed to compare preventive care in gastrointestinal (GI) diseases through a librarian review study.Results:
There is a close interaction between GI system and other body systems; any ailment in a system could result in dysfunction of stomach and vice versa. There are various herbal medicines that help achieving a healthy stomach following a seven-part preventive rule and in this article, we briefly reviewed some of them such as amla, clove, lemon, black mustard, saffron, ginger, aloe, and mastic.Conclusions:
Following a simple seven-part rule of healthy stomach will result in balanced GI function and a healthy body. Properly consumption of recommended TPM herbal medicines could reinforce the stomach and a healthy GI system through preventive mechanisms.Keywords
Preventive Medicine Gastrointestinal Diseases Oriental Traditional Medicine Herbal Medicine Stomach
1. Context
Gastrointestinal (GI) diseases are among the most common disabilities worldwide. They cause morbidities, economic, and social effects such as decreased quality of life, higher cost of care, and school absenteeism (1-3). One of the most effective experienced ways to overcome the abovementioned hazards is substituting prevention for treatment (4) and consequently, health policymakers should pay more attention to promotion of preventive care and progressively invest in this filed (5, 6). Traditional Persian Medicine (TPM), as an ancient valuable school, concentrates on preventive principles (Osul-e Hifzosiha), especially in the field of GI system (7). Based on quadratic elements (fire, air, water, and soil) and their qualities, GI system accomplishes its inborn normal function. As every subject has specific quality related to its element(s) dominancy in its structure, called temperament or mizadj, different effects are considered (8-11). According to TPM scholars’ view, stomach has a cardinal role in body health (12). It functions as a main system in supplying other organs requirements including growth and development. If it works correctly, balanced humors will be generated, which are essential for health (8, 13). The aim of this study was to review the preventive principles of TPM in healthy stomach topic and evaluate them with new scientific findings.
2. Evidence Acquisition
We searched main books of TPM scholars including Al-Havi (by Razes), Canon of Medicine (by Avicenna), and Exir Azam (by Hakim Azam Khan) for GI prevention explanations. Moreover, a comprehensive web search was performed in PubMed, Medline, Scopus, Web of Science, and scientific information database (SID) through March 2014 with the following keywords: stomach, prevention of GI disorders, and traditional medicine.
4. Conclusions
According to TPM resources, GI system including stomach has special preventive instructions to be obeyed accurately. Observing the seven-part rules of healthy stomach will lead to a balance in hotness, coldness, moistness, and dryness of stomach and an empowered stomach faculties. Appropriate use of recommended TPM herbal medicines with specific temperaments (Table 2) and observing essential prerequisites for the prevention of diseases (Osul-e Hifzosiha) for healthy stomach are of great importance in the abovementioned rules (14). The efficacy of some herbal medicines for good function of GI system has been proved in modern medicine. For example, most of 51 essential oils discussed in TPM resources have GI usage for diverse disorders ranging from otitis to hemorrhoid in special dosage forms (40-46). Although the safety and the detection of mechanism of action in herbal preparations are always a matter of concern, the attention has been curved towards ancient medical systems and herbal medicines because of the adverse effects and increasing failure of contemporary drugs (47-49). These effects have been discussed in TPM based on their temperaments and their components could explain these qualities. For instance, mastic is rich in phenolic compounds, which are attributed to hot and dry temperaments (mizadj) (16). The common note seen in modern studies about plants usage in prevention of GI disorders is gastroprotective effect of such herbal medicines. They are good sources of antioxidant, antimicrobial, anti-ulcer, anti-H. pylori, and gastro-protective agents. The fundamental role of antioxidant agents in gastric protection is documented through diverse pathways including regulation of acid secretion and improvement of mucosal blood flow (50-52). On the other hand, antimicrobial, anti-ulcer, anti-H. pylori, and gastroprotective characteristics of drug plants on GI system fitness are not necessary to be discussed, considering the importance of the preservation of gut microbiota (53). Furthermore, most of these plants are good sources of essential oils (Table 1). As we know, essential oils are secondary metabolites of aromatic herbs and their protective role as antibacterial, antiviral, and antifungal agents has been established (54) and it is surprising that we understand that scented plants have tonic effect on organs such as stomach regarding TPM views (8, 9, 14). The long list of priorities of preventive care makes the application of seven-part rules of healthy stomach rational and intellectual. There are numerous trials evaluating herbal medicines in TPM field (55, 56), but there is a vast area for new clinical trials on TPM herbal medicines, as preventive remedies, waiting for clever scientists.
Acknowledgements
References
-
1.
Gikas A, Triantafillidis JK. The role of primary care physicians in early diagnosis and treatment of chronic gastrointestinal diseases. Int J Gen Med. 2014;7:159-73. [PubMed ID: 24648750]. https://doi.org/10.2147/IJGM.S58888.
-
2.
Jafari P, Asadollahi Z, Moini M, Seyed Mirzaie M. Health Related Quality of Life in Iranian Patients With Irritable Bowel Syndrome: Reliability and Validity of the Persian Version of the IBS-QOL. Iran Red Crescent Med J. 2013;15(8):723-8. [PubMed ID: 24578842]. https://doi.org/10.5812/ircmj.4605.
-
3.
Brook RA, Kleinman NL, Choung RS, Melkonian AK, Smeeding JE, Talley NJ. Functional dyspepsia impacts absenteeism and direct and indirect costs. Clin Gastroenterol Hepatol. 2010;8(6):498-503. [PubMed ID: 20304102]. https://doi.org/10.1016/j.cgh.2010.03.003.
-
4.
Valente SL, Wemple D, Ramos S, Cashman SB, Savageau JA. Preventive Behaviors and Knowledge of Tick-Borne Illnesses: Results of a Survey From an Endemic Area. J Public Health Manag Pract. 2014. [PubMed ID: 24762630]. https://doi.org/10.1097/PHH.0000000000000098.
-
5.
Milsom KM, Rice A, Kearney-Mitchell P, Kellett L. A review of a child population dental preventive programme in Halton and St Helens. Br Dent J. 2014;216(8):E18. [PubMed ID: 24762921]. https://doi.org/10.1038/sj.bdj.2014.334.
-
6.
Norwati D, Harmy MY, Norhayati MN, Amry AR. Colorectal cancer screening practices of primary care providers: results of a national survey in Malaysia. Asian Pac J Cancer Prev. 2014;15(6):2901-4. [PubMed ID: 24761922].
-
7.
Ahmad S, Rehman S, Ahmad AM, Siddiqui KM, Shaukat S, Khan MS, et al. Khamiras, a natural cardiac tonic: An overview. J Pharm Bioallied Sci. 2010;2(2):93-9. [PubMed ID: 21814439]. https://doi.org/10.4103/0975-7406.67009.
-
8.
Ibn Sina AAH. Al Qanun Fi al-Tibb [in Arabic]. Lebanon: Alamy Le- Al-Matbooat Institute; 2005.
-
9.
Azam Khan M. Exir Azam [in Persian]. Tehran: Institute of Meical History, Islamic Medicine and Complementary Medicine; Iran Medical University; 2008.
-
10.
Javed G, Anwar M, Siddiqui MA. Perception of psychiatric disorders in the Unani system of medicine – a review. Eur J Integr Med. 2009;1(3):149-54.
-
11.
Nasiri Toosi M, Shams Ardekani MR, Minaie MB, Nazim I, Esfahani MM, Khadem A. Fatty Liver Disease From the Perspective of Traditional Iranian Medicine. Quran Med. 2014;3(1).
-
12.
Shirzad M, Mosaddegh M, Minaii B, Nikbakht Nasrabadi A, Ahmadian-Attari MM. The relationship between heart and stomach in Iranian traditional medicine: a new concept in cardiovascular disease management. Int J Cardiol. 2013;165(3):556-7. [PubMed ID: 22974730]. https://doi.org/10.1016/j.ijcard.2012.09.006.
-
13.
Pasalar M, Zarshenas MM, Lankarani KB. Good Digestion is a Key Element for Healthy Hearts: An Appealing Concept from Avicenna's Viewpoint. Med Hypothesis Discov Innov Interdisciplinary J. 2014;1(1):15-7.
-
14.
Razi MZ. Al-Havi Fi Al-Tibb [in Arabic]. Beirut: Dar Al Kotob Al-islmiyah; 2000.
-
15.
Aghili Shirazi MH. Makhzan-al-advia [in Persian]. Tehran: Tehran University of Medical Sciences; 2009.
-
16.
Ardekani MR, Rahimi R, Javadi B, Abdi L, Khanavi M. Relationship between temperaments of medicinal plants and their major chemical compounds. J Tradit Chin Med. 2011;31(1):27-31. [PubMed ID: 21563502].
-
17.
Mehrotra S, Jamwal RR, Meena DK, Mishra K, Patra R, Shyam R, et al. Anti-Helicobacter pylori and antioxidant properties of Emblica officinalis pulp extract: A potential source for therapeutic use against gastric ulcer. Med Plants Res J. 2011;5(12):2577-83.
-
18.
Hari Kumar KB, Sabu MC, Lima PS, Kuttan R. Modulation of haematopoetic system and antioxidant enzymes by Emblica officinalis gaertn and its protective role against gamma-radiation induced damages in mice. J Radiat Res. 2004;45(4):549-55. [PubMed ID: 15635265].
-
19.
Farzaei MH, Shams-Ardekani MR, Abbasabadi Z, Rahimi R. Scientific evaluation of edible fruits and spices used for the treatment of peptic ulcer in traditional Iranian medicine. ISRN Gastroenterol. 2013;2013:136932. [PubMed ID: 24066235]. https://doi.org/10.1155/2013/136932.
-
20.
Li Y, Xu C, Zhang Q, Liu JY, Tan RX. In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases. J Ethnopharmacol. 2005;98(3):329-33. [PubMed ID: 15814268]. https://doi.org/10.1016/j.jep.2005.01.020.
-
21.
Joshi B, Sah GP, Basnet BB, Bhatt MR, Sharma D, Subedi K, et al. Phytochemical extraction and antimicrobial properties of different medicinal plants: Ocimum sanctum (Tulsi), Eugenia caryophyllata (Clove), Achyranthes bidentata (Datiwan) and Azadirachta indica (Neem). J Microbiol Antimicrob. 2011;3(1):1-7.
-
22.
Rozza AL, Moraes TM, Kushima H, Tanimoto A, Marques MOM, Bauab TM, et al. Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: Involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E2. Chem Biol Interact. 2011;189((1-2)):82-9. https://doi.org/10.1016/j.cbi.2010.09.031.
-
23.
Radha krishnan K, Babuskin S, Azhagu Saravana Babu P, Sasikala M, Sabina K, Archana G, et al. Antimicrobial and antioxidant effects of spice extracts on the shelf life extension of raw chicken meat. Int J Food Microbiol. 2014;171:32-40. [PubMed ID: 24308943]. https://doi.org/10.1016/j.ijfoodmicro.2013.11.011.
-
24.
Alam MB, Hossain MS, Ekramul Haque M. Antioxidant and anti-inflammatory activities of the leaf extract of Brassica nigra. Int J Pharm Sci Res. 2011;2(2):303-10.
-
25.
Zaidi SF, Yamada K, Kadowaki M, Usmanghani K, Sugiyama T. Bactericidal activity of medicinal plants, employed for the treatment of gastrointestinal ailments, against Helicobacter pylori. J Ethnopharmacol. 2009;121(2):286-91. [PubMed ID: 19041711]. https://doi.org/10.1016/j.jep.2008.11.001.
-
26.
al-Yahya MA, Rafatullah S, Mossa JS, Ageel AM, Parmar NS, Tariq M. Gastroprotective activity of ginger Zingiber officinale rosc., in albino rats. Am J Chin Med. 1989;17(1-2):51-6. [PubMed ID: 2589236]. https://doi.org/10.1142/S0192415X89000097.
-
27.
Goel R, Sairam K. Anti-ulcer drugs from indigenous sources with emphasis on Musa sapientum, tamrahbasma, Asparagus racemosus and Zingiber officinale. Indian J Pharmacol. 2002;34(2):100-10.
-
28.
Khushtar M, Kumar V, Javed K, Bhandari U. Protective Effect of Ginger oil on Aspirin and Pylorus Ligation-Induced Gastric Ulcer model in Rats. Indian J Pharm Sci. 2009;71(5):554-8. [PubMed ID: 20502577]. https://doi.org/10.4103/0250-474X.58195.
-
29.
Nanjundaiah SM, Annaiah HN, Dharmesh SM. Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract: Role of Gallic Acid and Cinnamic Acid in H(+), K(+)-ATPase/H. pylori Inhibition and Anti-Oxidative Mechanism. Evid Based Complement Alternat Med. 2011;2011:249487. [PubMed ID: 19570992]. https://doi.org/10.1093/ecam/nep060.
-
30.
Cao ZF, Chen ZG, Guo P, Zhang SM, Lian LX, Luo L, et al. [Scavenging effects of ginger on superoxide anion and hydroxyl radical]. Zhongguo Zhong Yao Za Zhi. 1993;18(12):750-1. [PubMed ID: 8011089].
-
31.
Borrelli F, Izzo AA. The plant kingdom as a source of anti-ulcer remedies. Phytother Res. 2000;14(8):581-91. [PubMed ID: 11113992].
-
32.
Dat AD, Poon F, Pham KB, Doust J. Aloe vera for treating acute and chronic wounds. Cochrane Database Syst Rev. 2012;2:CD008762. [PubMed ID: 22336851]. https://doi.org/10.1002/14651858.CD008762.pub2.
-
33.
Wang Y, Han T, Zhu Y, Zheng CJ, Ming QL, Rahman K, et al. Antidepressant properties of bioactive fractions from the extract of Crocus sativus L. J Nat Med. 2010;64(1):24-30. [PubMed ID: 19787421]. https://doi.org/10.1007/s11418-009-0360-6.
-
34.
Akhondzadeh Basti A, Moshiri E, Noorbala AA, Jamshidi AH, Abbasi SH, Akhondzadeh S. Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(2):439-42. [PubMed ID: 17174460]. https://doi.org/10.1016/j.pnpbp.2006.11.010.
-
35.
Samarghandian S, Borji A. Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients. Pharmacognosy Res. 2014;6(2):99-107. [PubMed ID: 24761112]. https://doi.org/10.4103/0974-8490.128963.
-
36.
Hosseinzadeh H, Nassiri-Asl M. Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review. Phytother Res. 2013;27(4):475-83. [PubMed ID: 22815242]. https://doi.org/10.1002/ptr.4784.
-
37.
Bathaie SZ, Miri H, Mohagheghi MA, Mokhtari-Dizaji M, Shahbazfar AA, Hasanzadeh H. Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat. Iran J Basic Med Sci. 2013;16(1):27-38. [PubMed ID: 23638290].
-
38.
Shamsi-Baghbanan H, Sharifian A, Esmaeili S, Minaei B. Hepatoprotective herbs, avicenna viewpoint. Iran Red Crescent Med J. 2014;16(1). eee12313. [PubMed ID: 24719702]. https://doi.org/10.5812/ircmj.12313.
-
39.
Koutsoudaki C, Krsek M, Rodger A. Chemical composition and antibacterial activity of the essential oil and the gum of Pistacia lentiscus Var. chia. J Agric Food Chem. 2005;53(20):7681-5. [PubMed ID: 16190616]. https://doi.org/10.1021/jf050639s.
-
40.
Hamedi A, Zarshenas MM, Sohrabpour M, Zargaran A. Herbal medicinal oils in traditional Persian medicine. Pharm Biol. 2013;51(9):1208-18. [PubMed ID: 23746335]. https://doi.org/10.3109/13880209.2013.777462.
-
41.
Marone P, Bono L, Leone E, Bona S, Carretto E, Perversi L. Bactericidal activity of Pistacia lentiscus mastic gum against Helicobacter pylori. J Chemother. 2001;13(6):611-4. [PubMed ID: 11806621]. https://doi.org/10.1179/joc.2001.13.6.611.
-
42.
Paraschos S, Magiatis P, Mitakou S, Petraki K, Kalliaropoulos A, Maragkoudakis P, et al. In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrob Agents Chemother. 2007;51(2):551-9. [PubMed ID: 17116667]. https://doi.org/10.1128/AAC.00642-06.
-
43.
Dabos KJ, Sfika E, Vlatta LJ, Frantzi D, Amygdalos GI, Giannikopoulos G. Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial. J Ethnopharmacol. 2010;127(2):205-9. [PubMed ID: 19961914]. https://doi.org/10.1016/j.jep.2009.11.021.
-
44.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 3rd ed. Montvale, NJ: Thomson Pdr; 2004. 1351 p.
-
45.
Ibn al-Nafis A. Al-Shamel fi Sana'at al-Tibbi'at [in Persian]. Tehran: Institute of Meical History, Islamic Medicine and Complementary Medicine; 2008.
-
46.
Zarshenas MM, Zargaran A, Muller J, Mohagheghzadeh A. Nasal drug delivery in traditional persian medicine. Jundishapur J Nat Pharm Prod. 2013;8(3):144-8. [PubMed ID: 24624204].
-
47.
Sattari M, Dilmaghanizadeh M, Hamishehkar H, Mashayekhi SO. Self-reported Use and Attitudes Regarding Herbal Medicine Safety During Pregnancy in Iran. Jundishapur J Nat Pharm Prod. 2012;7(2):45-9. [PubMed ID: 24624153].
-
48.
Singla RK, Bhat GV, Gonzalez-Diaz H. Editorial: from phytochemistry to medicinal chemistry: isolation, semisynthesis, evaluation and computational studies. Curr Top Med Chem. 2014;14(8):979-80.
-
49.
Aminolroayaee Yamini E. Some questions about herbal and traditional medicine. Nurs Midwifery Stud. 2014;3(1). eee18079. [PubMed ID: 25414896].
-
50.
Chandranath SI, Bastaki SM, Singh J. A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat. Clin Exp Pharmacol Physiol. 2002;29(3):173-80. [PubMed ID: 11906479].
-
51.
Brzozowski T, Konturek PC, Konturek SJ, Brzozowska I, Pawlik T. Role of prostaglandins in gastroprotection and gastric adaptation. J Physiol Pharmacol. 2005;56 Suppl 5:33-55. [PubMed ID: 16247188].
-
52.
Rahimi HR, Kazemi Oskuee R. Curcumin From Traditional Iranian Medicine to Molecular Medicine. Razavi Int J Med. 2014;2(2).
-
53.
Guglielmetti S, Mora D, Gschwender M, Popp K. Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2011;33(10):1123-32. [PubMed ID: 21418261]. https://doi.org/10.1111/j.1365-2036.2011.04633.x.
-
54.
Rozza AL, Pellizzon CH. Essential oils from medicinal and aromatic plants: a review of the gastroprotective and ulcer-healing activities. Fundam Clin Pharmacol. 2013;27(1):51-63. [PubMed ID: 22888975]. https://doi.org/10.1111/j.1472-8206.2012.01067.x.
-
55.
Jowkar F, Jamshidzadeh A, Mirzadeh Yazdi A, Pasalar M. The effects of fumaria parviflora L extract on chronic hand eczema: a randomized double-blind placebo controlled clinical trial. Iran Red Crescent Med J. 2011;13(11):824-8. [PubMed ID: 22737422].
-
56.
Pasalar M, Lankarani KB, Mehrabani D, Tolide-ie HR, Naseri M. he Effect of Descureania Sophia L. and Prunus Domestica L. in Prevention of Constipation among Iranian Hajj Pilgrims, Saudi Arabia. Res J Pharm Biol Chem Sci. 2013;4(2):1195-204.
reply
reply