FORMULATION OF AN ANTI-DERMATOPHYTE CREAM FROM HYDRO-ALCOHOLIC EXTRACT OF EUCALYPTUS CAMALDULENSIS LEAVES

E Moghimipour; A Ameri; A Saudatzadeh; A Salimi; A Siahpoosh

Jundishapur Journal of Natural Pharmaceutical Products

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

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FORMULATION OF AN ANTI-DERMATOPHYTE CREAM FROM HYDRO-ALCOHOLIC EXTRACT OF EUCALYPTUS CAMALDULENSIS LEAVES

Author(s):

E Moghimipour^1,*,

A Ameri²,

A Saudatzadeh²,

A Salimi²,

A Siahpoosh³

1Medical plants Research Center, Ahvaz Jundishapur University of Medical Sciences, moghimipour_e@ajums.ac.ir, Iran

2Department of Food Science and Medical Hydrology, Ahvaz Jundishapur University of Medical Sciences, Iran

3Department of Pharmacognosy, Ahvaz

Jundishapur Journal of Natural Pharmaceutical Products:Vol. 4, issue 1; 32-40

Article type:Research Article

Received:Nov 16, 2007

Accepted:May 28, 2010

How to Cite:E MoghimipourA AmeriA SaudatzadehA SalimiA SiahpooshFORMULATION OF AN ANTI-DERMATOPHYTE CREAM FROM HYDRO-ALCOHOLIC EXTRACT OF EUCALYPTUS CAMALDULENSIS LEAVES.Jundishapur J Nat Pharm Prod.4(1):32-40.

Abstract

Throughout the world, there has been an increasing incidence of fungal infections, and because of drug resistance and toxicity associated with long-term treatment with antifungal drugs, search for new drugs to treat fungal infections is ongoing. The aim of the present study was to formulate herbal antifungal cream containing hydro-alcoholic extract of Eucalyptus camaldulensis as an anti-dermatophytic preparation and evaluate its physicochemical properties and stability. Firstly, the minimum inhibitory concentration (MIC) of hydro-alcoholic extract of leaves of E. camaldulensis was determined against various dermatophyte species by in vitro tube dilution technique. To select the best cream formulation, one general formula of cleansing cream was considered and then corrected. The best base formula was chosen according to its monotonousness, straightness and external attractiveness. The formulation containing 1% of the plant extract was prepared and controlled by standard methods. Finally, a cream containing bees wax 10%, liquid paraffin 58.8%, hard paraffin 1.2%, spermaceti 5%, borax 1.5%, tween 80 1.5%, 0.15% methyl paraben, 0.05% propyl paraben, 0.15% lactic acid, 1% Eucalyptus extract and water was chosen as the best formulation. The final product was a w/o emulsion cream with suitable appearance and desirable physicochemical stability. Due to the stability of the extract in the cream formulation, it can be formulated for treatment of fungal skin infections.

Keywords

Eucalyptus camaldulensis

Cream

Dermatophyte.

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