CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF ZHUMERIA MAJDAE RESH. F.& WENDELBO

F Sharififar; V Mozaffarian; MH Moshafi; G Dehghan-Nudeh; J Parandeh-Rezvani; Z Mahdavi

Jundishapur Journal of Natural Pharmaceutical Products

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

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CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF ZHUMERIA MAJDAE RESH. F.& WENDELBO

Author(s):

F Sharififar^1,*,

V Mozaffarian²,

MH Moshafi³,

G Dehghan-Nudeh³,

J Parandeh-Rezvani³,

Z Mahdavi³

1Department of pharmacognosy, School of pharmacy, Pharmaceutics Research Center, Kerman University of medical sciences, fsharififar@kmu.ac.ir, Iran

2Department of botany, Research Institute of Forests and Rangelands, Iran

3Department of pharmaceutics, School of pharmacy, Pharmaceutics Research Center, Kerman University of medical sciences, Iran

Jundishapur Journal of Natural Pharmaceutical Products:Vol. 3, issue 1; 8-18

Article type:Research Article

Received:Feb 02, 2008

Accepted:May 31, 2008

How to Cite:F SharififarV MozaffarianMH MoshafiG Dehghan-NudehJ Parandeh-RezvaniZ Mahdaviet al.CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF ZHUMERIA MAJDAE RESH. F.& WENDELBO.Jundishapur J Nat Pharm Prod.3(1):8-18.

Abstract

Zhumeria majdae Resh. f.& Wendelbo. (Lamiaceae) is a medicinal plant which has long been used in traditional medicine as antispasmodic, antimicrobial, carminative especially in infants and for dysmenorrheal. The therapeutic benefits of medicinal plants are often attributed to their antioxidant properties. The present study was conducted to evaluate in vitro antibacterial and antioxidant properties of essential oil and various extracts of Zhumeria majdae Resh. f & Wendelbo. The GC and GC–MS analysis of the essential oil were resulted in the determination of 26 components representing 97.2% of the oil. Linalool (53.28%) and camphor (26.15%) were the main components. The essential oil has exhibited antibacterial activity against all tested bacteria. Antioxidant activities of the samples were determined DPPH and β-carotene/linoleic acid methods. The essential oil and methanol extract reduced the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) with an IC50 of 20.5 ± 1.6 and 26.1 ± 1.5 respectively. In the latter method, the methanol extract and essential oil have shown the most activity with 25.8 and 19.2 mm mean zone of color retention respectively. The amount of the total phenolics was highest in methanol extract (50.1 ± 2.3μg/mg). A positive correlation was observed between the antioxidant activity potential and total phenolic level of the extracts. Results here show that the essential oil and methanol extract of Z. majdae possess antioxidant and antibacterial activity, and could be used as natural preservative in food and /or pharmaceutical industries. The other extracts have exhibited no activity.

Keywords

Antioxidant activity

Antibacterial activity

?-carotene/linoleic acid

DPPH.

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