THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT

A Arzi; AA Hemmati; S Ghobishavi; L Arzi

Jundishapur Journal of Natural Pharmaceutical Products

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

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THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT

Author(s):

A Arzi^1,*,

AA Hemmati²,

S Ghobishavi²,

L Arzi³

1Department of Pharmacology and Toxicology, School of Pharmacy Jundishapur University of Medical Sciences, [email protected], Iran

2Department of Pharmacology and Toxicology, School of Pharmacy Jundishapur University of Medical Sciences, Iran

3Institute of Biophysics and Biochemistry, Tehran University, Iran

Jundishapur Journal of Natural Pharmaceutical Products:Vol. 2, issue 1; 18-24

Article type:Research Article

Received:Feb 21, 2006

Accepted:Jul 20, 2007

How to Cite:A Arzi, AA Hemmati, S Ghobishavi, L Arzi, THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT.Jundishapur J Nat Pharm Prod.2(1):18-24.

Abstract

Catatonia is one of the major signs of parkinson’s disease which is due to impaired dopamine in extrapyrmidal system. This study was performed to elucidate the role of L-tyrosine, vitamin E and vitamin C on perphenazine-induced catatonia in model of rat. Eight groups of rats were pretreated orally by a single dose of L-tyrosine (1500 mg/kg), vitamin E (250 mg/kg), vitamin C (300 mg/kg), vitamin E plus vitamin C, vitamin E plus L-tyrosine, vitamin C plus L-tyrosine, vitamins E and C plus L-tyrosine and normal saline (control group) for two weeks, respectively. One hour after the last dose, perphenazine (5 mg/kg) was administered (IP) to induce catatonia. Muscular rigidity of animals was determined by scoring method of Morpurgo. The results of this study indicate that L-tyrosine plus vitamins E and C could reduce the perphenazine-induced muscular rigidity better than other groups.

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