THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT

authors:

avatar A Arzi 1 , * , avatar AA Hemmati 2 , avatar S Ghobishavi 2 , avatar L Arzi 3

Department of Pharmacology and Toxicology, School of Pharmacy Jundishapur University of Medical Sciences, arzi_ardeshir@yahoo.com, Iran
Department of Pharmacology and Toxicology, School of Pharmacy Jundishapur University of Medical Sciences, Iran
Institute of Biophysics and Biochemistry, Tehran University, Iran
Jundishapur Journal of Natural Pharmaceutical Products: Vol.2, issue 1; 18-24
article type: Research Article
received: February 21, 2006
accepted: July 20, 2007

how to cite: Arzi A, Hemmati A, Ghobishavi S, Arzi L. THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT. Jundishapur J Nat Pharm Prod. 2007;2(1): 18-24. 

Abstract

Catatonia is one of the major signs of parkinson’s disease which is due to impaired dopamine in extrapyrmidal system. This study was performed to elucidate the role of L-tyrosine, vitamin E and vitamin C on perphenazine-induced catatonia in model of rat. Eight groups of rats were pretreated orally by a single dose of L-tyrosine (1500 mg/kg), vitamin E (250 mg/kg), vitamin C (300 mg/kg), vitamin E plus vitamin C, vitamin E plus L-tyrosine, vitamin C plus L-tyrosine, vitamins E and C plus L-tyrosine and normal saline (control group) for two weeks, respectively. One hour after the last dose, perphenazine (5 mg/kg) was administered (IP) to induce catatonia. Muscular rigidity of animals was determined by scoring method of Morpurgo. The results of this study indicate that L-tyrosine plus vitamins E and C could reduce the perphenazine-induced muscular rigidity better than other groups.

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