THE EFFECT OF SELEGILINE AND BROMOCRIPTINE IN THE PROPHYLAXIS OF PERPHENAZINE-INDUCED PSEUDOPARKINSONISM IN RAT: A COMPARATIVE STUDY

authors:

avatar A Arzi 1 , * , avatar A.A Hemmati 2 , avatar M.H Pipelzadeh 2 , avatar S.M Latifi 2 , avatar F Ramesh 2

Department of Pharmacology & Toxicology, School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, Arzi_Ardeshir@yahoo.com
Department of Pharmacology & Toxicology, School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences
Jundishapur Journal of Natural Pharmaceutical Products: Vol.1, issue 1; 36-40
article type: Research Article
received: May 25, 2004
accepted: June 18, 2006

How To Cite Arzi A, Hemmati A, Pipelzadeh M, Latifi S, Ramesh F. THE EFFECT OF SELEGILINE AND BROMOCRIPTINE IN THE PROPHYLAXIS OF PERPHENAZINE-INDUCED PSEUDOPARKINSONISM IN RAT: A COMPARATIVE STUDY. Jundishapur J Nat Pharm Prod. 2006;1(1): 36-40. 

Abstract

Parkinsonism is a neurodegenerative disease that is defiend by certain symtom as muscle rigidity , impaired movement , tremor and disorientation of body. The aim of the present study was to compare the efficacy of selegiline and bromocriptine in the prevention of experimentally induced pseudoparkinsonism in rat. Perphenazine (5mg/kg) was used (IP) as the inducing agent. Different groups of rats were pretreated by either selegiline (2.5, 5, 10, and 20mg/kg), or effective dose of bromocriptine (30mg/kg). The degree of prevention of catatonic reaction was compared with control group. The results showed all selegiline-treated groups had significant reduction in the catatonic reaction relative to sham treated group. In addition, 20mg/kg selegiline had more intensive effect to reduce the catatonic reaction than bromocriptine (30mg/kg). Selegiline seems to be a suitable drug to prevent perphenazine–induced catatonia in rat.

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