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Jundishapur Journal of Natural Pharmaceutical Products
The Official Journal of Ahvaz Jundishapur University of Medical Sciences
e-ISSN 2228-7876
p-ISSN 1735-7780
THE EFFECT OF SELEGILINE AND BROMOCRIPTINE IN THE PROPHYLAXIS OF PERPHENAZINE-INDUCED PSEUDOPARKINSONISM IN RAT: A COMPARATIVE STUDY
Authors
1Department of Pharmacology & Toxicology, School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, [email protected]
2Department of Pharmacology & Toxicology, School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences
*Corresponding Author: Department of Pharmacology & Toxicology, School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, [email protected]. Email: [email protected]
Published online:Dec 20, 2006
Article type:Research Article
Received:May 25, 2004
Accepted:Jun 18, 2006
How to Cite:Arzi A, Hemmati A, Pipelzadeh M, Latifi S, Ramesh F. THE EFFECT OF SELEGILINE AND BROMOCRIPTINE IN THE PROPHYLAXIS OF PERPHENAZINE-INDUCED PSEUDOPARKINSONISM IN RAT: A COMPARATIVE STUDY. Jundishapur J Nat Pharm Prod. 2006;1(1):. doi:
Abstract
Parkinsonism is a neurodegenerative disease that is defiend by certain symtom as muscle rigidity , impaired movement , tremor and disorientation of body. The aim of the present study was to compare the efficacy of selegiline and bromocriptine in the prevention of experimentally induced pseudoparkinsonism in rat. Perphenazine (5mg/kg) was used (IP) as the inducing agent. Different groups of rats were pretreated by either selegiline (2.5, 5, 10, and 20mg/kg), or effective dose of bromocriptine (30mg/kg). The degree of prevention of catatonic reaction was compared with control group. The results showed all selegiline-treated groups had significant reduction in the catatonic reaction relative to sham treated group. In addition, 20mg/kg selegiline had more intensive effect to reduce the catatonic reaction than bromocriptine (30mg/kg). Selegiline seems to be a suitable drug to prevent perphenazine–induced catatonia in rat.
Copyright
© 2006, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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