Immunohistochemistry of Inflammatory myofibroblastic tumors

Mohsen Emami Aleagha; Ahmad Faramarzi; Sedigheh  Khazaei; Sayed Hamid Madani; Rostam Ghorbani

Journal of Kermanshah University of Medical Sciences

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Immunohistochemistry of Inflammatory myofibroblastic tumors

Author(s):

Mohsen Emami Aleagha¹,

Ahmad Faramarzi^2,*,

Sedigheh Khazaei²,

Sayed Hamid Madani²,

Rostam Ghorbani³

1Dept. of pathology, Kermanshah University of Medical Science, Kermanshah, Iran

2Dept. of pathology, Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah, Iran

3Dept.of Anatomy & Histology, Kermanshah University of Medical Science, Kermanshah, Iran

Journal of Kermanshah University of Medical Sciences:Vol. 13, issue 3; e79599

Published online:Dec 19, 2009

Article type:Research Article

Received:Apr 09, 2009

Accepted:Sep 08, 2009

How to Cite:Mohsen Emami AleaghaAhmad FaramarziSedigheh KhazaeiSayed Hamid MadaniRostam GhorbaniImmunohistochemistry of Inflammatory myofibroblastic tumors.J Kermanshah Univ Med Sci.13(3):e79599.

Abstract

Background: Inflammatory myofibroblastic tumor (IMT) or inflammatory pseudotumor is a tumoral lesion which can be seen in all age groups and in all internal organs. It is in differential diagnosis with some important neoplasms such as Leiomyosarcoma, Rhabdomyosarcoma, and Sarcomatoid carcinoma. Differentiation between these tumors requires a special diagnostic tool such as Immunohistochemistry (IHC). This study aimed to identify Immunohistochemical characteristics of inflammatory myofibroblastic tumors.

Methods: 19 cases included in this cross-sectional study. All cases with diagnosis of :" Inflammatory myofibroblastic tumor" or " Inflammatory pseudotumor" at pathobiology laboratories of Kermanshah university, Tehran Imam Khomaini Hospital and Institute of Cancer were selected and studied by using IHC stains for CK, EMA, SMA, MSA, Desmin, P53, ALK and Vimentin .

Results: Mean age of cases was 40.4 year . 52.6% were male and 47.4% female. Most frequent affected organs were; Stomach (4 cases), Urinary Bladder (3 cases), Small Intestine (3 cases), Lung and Mediastinum (3cases), Omentum (2 cases), Retroperitoneum (1 case), Cervix(1 case), Urethra(1 case) and gluteus Maximus Muscle (1 case), . Vimentin (94.7%) , MSA (57.9%) and SMA (47.4%) were the most frequent expressed IHC biomarkers in diagnosed tumors respectively.

Conclusion: CK is a reliable marker for differentiation between these lesions and Sarcomatoid carcinoma. For differentiation from Leiomyosarcoma, Rhabdomyosarcoma and Postoperative Spindle Cell Nodule, using Desmin is a useful biomarker. It is recommended that "IMT" be used for those lesions that express ALK and/or those that cytogenetic studies reveal a fusion of introducing genes. Other lesions should be classified and reported as "Inflammatory Pseudotumor.

Keywords

Inflammatory myofibroblastic tumor

IMT

IHC

ALK

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