Does Swimming Moderate the Negative Effects of Maternal Deprivation on Hippocampal BDNF Levels, Spatial Learning and Motor Function?

authors:

avatar Mozhgan Abdollahzadeh ORCID 1 , avatar Shahzad Tahmasebi Boroujeni ORCID 2 , * , avatar Elahe Arabameri ORCID 3

MSc at Motor control and Learning, Department of Behavioral and Cognitive Sciences in Sport, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran
Associate Professor, Department of Behavioral and Cognitive Sciences in Sport, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran.
Associate Professor, Department of Behavioral and Cognitive Sciences in Sport, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran
International Journal of Motor Control and Learning: Vol.5, issue 2; 21-28
published online: May 16, 2023
article type: Research Article
received: February 06, 2023
accepted: May 13, 2023
DOI: https://doi.org/10.61186/ijmcl.5.2.21

how to cite: Abdollahzadeh M, Tahmasebi Boroujeni S, Arabameri E. Does Swimming Moderate the Negative Effects of Maternal Deprivation on Hippocampal BDNF Levels, Spatial Learning and Motor Function?. J Motor Control Learn. 2023;5(2):e144158. https://doi.org/10.61186/ijmcl.5.2.21.

Abstract

Background: Previous research has emphasized the negative impact of early maternal deprivation on learning and memory. On the other hand, the role of training on cognition has been examined. However, whether neonates are given exercise at the same time as being deprived of their mothers is a novelty of this research. We also considered the study of underlying mechanisms, such as the study of changes in BDNF levels. So, the purpose of this study was to examine the effect of swimming training on spatial learning, memory and motor function in male rats under early deprivation. 
Methods: Twenty-eight rats divided into four groups: Early maternal deprivation (EMD), Swimming Training (ST), EMD+ST group, and Control (CON) groups. The rats were exposed to deprivation for 10 days, three days a week for 30 minutes. The rats were at 33 postnatal days and their spatial learning and memory were assessed using the Morris Water Maze (MWM) test. Rats' motor function was assessed by the Open-Field (OF) test. Finally, after the extraction of the hippocampus, BDNF protein was measured by ELISA. 
Results: The results of this study revealed that male rats exposed to EMD had learning and spatial memory impairments, lower hippocampal BDNF protein levels. In addition, swimming alone has a positive impact on the BDNF protein level and motor function. 
Conclusions: Despite these findings, due to the high intensity of stress, swimming could not modify the irreparable effects of deprivation.

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