Formulation and Optimization of Effervescent Tablet Containing Bismuth Sub-citrate

Somayeh Taymouri; Abolfazl Mostafavi; Mohamad Javanmardi

doi:10.4103/jrptps.JRPTPS_11_19

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https://doi.org/10.4103/jrptps.JRPTPS_11_19

Formulation and Optimization of Effervescent Tablet Containing Bismuth Sub-citrate

Author(s):

Somayeh Taymouri¹,

Abolfazl Mostafavi^2,*,

Mohamad Javanmardi²

1Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran

2Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences and Isfahan pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 8, issue 2; 236-44

Published online:Dec 31, 2019

Article type:Research Article

How to Cite:Somayeh TaymouriAbolfazl MostafaviMohamad JavanmardiFormulation and Optimization of Effervescent Tablet Containing Bismuth Sub-citrate.J Rep Pharm Sci.8(2):e147387.https://doi.org/10.4103/jrptps.JRPTPS_11_19.

Abstract

Objective: The objective of this study was to design, evaluate and optimize effervescent tablets containing bismuth sub-citrate with sufficient hardness and friability in treatment of peptic ulcer.
Materials and Methods: Effervescent tablets were prepared by direct compression method and were optimized using irregular factorial design. Amount of citric acid, sodium bicarbonate to citric acid molar ratio, polyvinyl pyrrolidone K 30 (PVP k30), polyethylene glycol 6000 (PEG 6000) were selected as independent variables, whereas disintegration time, amount of carbon dioxide (CO2), friability, pH, and hardness were selected as dependent variables. All the batches were assessed for various pre and post compression characteristics such as flowability, hardness, friability, effervescent time, pH, and content uniformity. For the enhancement of tablets’ palatability, the components of optimized formulation were mixed with same amounts of different flavoring agents.
Results: The best results obtained from effervescent tablets prepared by 500 mg citric acid, 5% PEG 6000 and 3% PVP k30 while the molar ratio of the sodium bicarbonate to citric acid was 3. The disintegration time, amount of CO2, friability, pH, and hardness of optimized formulation were confirmed to be 95.33 ± 1.15 sec, 398.73 ± 1.46 mg, 0.73%, 6.0 ± 0.06 and 72.3 ± 5.5 N, respectively. The most pleasant taste according to volunteers’ acceptability was the taste of cherry.
Conclusion: These results suggest that developed effervescent tablets may be promising for delivery of bismuth sub-citrate in peptic ulcers therapy.

Keywords

Bismuth sub-citrate

direct compression method

effervescent tablet

polyvinylpyrrolidone k 30

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Author(s):

Somayeh Taymouri:[PubMed][Scholar]
Abolfazl Mostafavi:[PubMed][Scholar]
Mohamad Javanmardi:[PubMed][Scholar]