Journal of Reports in Pharmaceutical Sciences
Synthesis and Characterization of Hydrazide-Hydrazone Derivatives of 3-Pyridine Carboxylic Acid as Antimycobacterial Tuberculosis Agents
Abstract
In this study synthesis of nicotinoyl hydrazone derivatives is investigated by introducing the nicotinicacidhydrazidepharmacophore into several molecules and screening for antimycobacterial activity. Benzaldehyde derivatives react with nicotinicacidhydrazideto form nicotinoylhydrazones.The synthesized compounds were screened against M. tuberculosis H37Rv, clinical isolates of M. tuberculosis and MDR clinical isolates of M. tuberculosisusing the proportion test. The minimum inhibitory concentration (MIC) of N'-(4-methylphenyl) nicotinicacidhydrazone and N'-(4-(N,N-dimethyl)phenyl)nicotinicacidhydrazone exhibited activity between 40 and 200μg/mL and could be a good start point to find new lead compounds against M. tuberculosis.
Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
Almasirad A, Samiee-Sadr S, Shafiee A. Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives. Iran J Pharm Res. 2011;10(4):e126007. doi: https://doi.org/10.22037/ijpr.2011.984
A Study on Antitubercular and Antimicrobial Activity of Isoniazid Derivative
Pahlavani E, Kargar H, Sepehri Rad N. A Study on Antitubercular and Antimicrobial Activity of Isoniazid Derivative. Zahedan J Res Med Sci. 2015;17(7):-. doi: https://doi.org/10.17795/zjrms1010
Synthesis and Antimicrobial Evaluation of 4H-Pyrans and Schiff Bases Fused 4H-Pyran Derivatives as Inhibitors of Mycobacterium bovis (BCG)
Mahdavi SM, Habibi A, Dolati H, Shahcheragh SM, Sardari S, et al. Synthesis and Antimicrobial Evaluation of 4H-Pyrans and Schiff Bases Fused 4H-Pyran Derivatives as Inhibitors of Mycobacterium bovis (BCG). Iran J Pharm Res. 2018;17(4):e124859. doi: https://doi.org/10.22037/ijpr.2018.2295
Design, Synthesis and Anti-Tubercular Activity of Novel 1, 4-Dihydropyrine-3, 5-Dicarboxamide Containing 4(5)-Chloro-2-Ethyl- 5(4)-Imidazolyl Moiety
Iman M, Davood A, Lotfinia M, Dehqani G, Sardari S, et al. Design, Synthesis and Anti-Tubercular Activity of Novel 1, 4-Dihydropyrine-3, 5-Dicarboxamide Containing 4(5)-Chloro-2-Ethyl- 5(4)-Imidazolyl Moiety. Iran J Pharm Res. 2016;15(4):e127510. doi: https://doi.org/10.22037/ijpr.2016.1932
Design, Synthesis and Evaluation of Antitubercular Activity of Novel Dihydropyridine Containing Imidazolyl Substituent
Iman M, Davood A, Dehqani G, Lotfinia M, Sardari S, et al. Design, Synthesis and Evaluation of Antitubercular Activity of Novel Dihydropyridine Containing Imidazolyl Substituent. Iran J Pharm Res. 2015;14(4):e125381. doi: https://doi.org/10.22037/ijpr.2015.1744
- Scopus by DOI: 0
Last Update: 1 week ago
- Scopus by Title: 4
Last Update: 1 week ago
- Scopus by Title (Ref): 4
Last Update: 1 week ago
- CrossRef: 0
Last Update: 5 days ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Author(s):