Journal of Semnan University of Medical Sciences
Effects of dexamethasone injection into dentate gyrus of the hippocampus on memory storage in rat
Authors
Abstract
Introduction. The present experiments examined the role of glucocorticoids in de nta t gyrus (DG) of the hippocampus on retention of passive avoida nce learning. Materials and Methods. Male wistar rats were implanted bilaterally with ca nnulae a imed at DG and were trained in one trial step-through passive avoidance task (1 rnA footshock, 1.5 s). Glucocorticoids receptor agonist dexamethasone (2.5 ,u g/ul per side) was injected bilaterally into DG immediately and 60, 90 or 120 min after training. Retention test was done two days later. Results. The dat a indicated that infusion of dexamethasone immediately and 60 min but not 90 or 120 min after training into DG significantly enhanced retention performance. Conclusion. The above results show that gluco corticoids play an important role in consolida tion of emotional memory in DG of the hippocampus at least 60 min after training.
Copyright
© 2000, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
The role of hippocampus and amygdala glucocorticoid receptors in modulation of memory storage process in rats
Vafaei AA, RashidiPor A. The role of hippocampus and amygdala glucocorticoid receptors in modulation of memory storage process in rats. koomesh. 2001;2(3):e151928. doi:
Effects of acute stress and corticosterone on fear memory extinction in mice
Dehbashi F, alizadeh N, RashidiPor A, Vafaie A. Effects of acute stress and corticosterone on fear memory extinction in mice. koomesh. 2012;13(3):e152524. doi:
Effects of activation and inactivation of glucocorticoid receptors of basolateral amygdala on fear memory extinction in rats
Omoumi S, Rashidy-Pour AL, Shafiee M, Vafaei AA. Effects of activation and inactivation of glucocorticoid receptors of basolateral amygdala on fear memory extinction in rats. koomesh. 2014;15(3):e153884. doi:
Effect of posttraining injections of glucocorticoid agonist and antagonist into the dorsal hippocampus on spatial memory storage in place avoidance learning task
Vafaei AA, RashidiPor A, Sharifi M, Borsh J. Effect of posttraining injections of glucocorticoid agonist and antagonist into the dorsal hippocampus on spatial memory storage in place avoidance learning task. koomesh. 2000;1(3):e153107. doi:
Adrenalectomy and glucocorticoid inhibition prevent the beneficial effects of voluntary exercise on fear memory and hippocampal neural counting in rats
Vafaei AA, Rashidy-Pour A, Hajisoltani R, Sameni HR. Adrenalectomy and glucocorticoid inhibition prevent the beneficial effects of voluntary exercise on fear memory and hippocampal neural counting in rats. koomesh. 2017;19(3):e152913. doi:
More by these authors
- Scopus by DOI: 0
Last Update: 1 month ago
- Scopus by Title: 0
Last Update: 1 month ago
- Scopus by Title (Ref): 0
Last Update: 1 month ago
- CrossRef: 0
Last Update: 6 days ago