Effects of Valeriane Officinalis, Satureja Hortensis, and Mentha Piperita extracts on the withdrawal syndrome signs in mice

authors:

avatar Abbas Ali Vafaei , avatar Hossein Miladi-Gorgi , * , avatar AbbasAli Taherian , avatar Mansoureh Bagherian

Koomesh: Vol.12, issue 3; 342-347
article type: Research Article
received: March 02, 2011

how to cite: Vafaei A A, Miladi-Gorgi H, Taherian A, Bagherian M. Effects of Valeriane Officinalis, Satureja Hortensis, and Mentha Piperita extracts on the withdrawal syndrome signs in mice. koomesh. 2011;12(3):e152466. 

Abstract

  Introduction: Several studies have demonstrated the antinociceptive, anti-inflammatory, sedative and smooth muscle relaxant activities of the Valeriane Officinalis (VO), Satureja Hortensis (SH), and Mentha Piperita (MP). The aim of this study was to determine the effects of the aqueous or hydroalcoholic extracts from these plants on morphine withdrawal syndrome signs in mice.   Materials and Methods: 112 male albino mice (25-30 g) were used. Morphine was used to produce drug dependency by Marshall method. Different doses of the aqueous extracts of VO (25, 50, 100 mg/kg) and SH (25, 50, 100, 200 mg/kg IP) and the hydroalcoholic extract of MP (50, 100, 200, 500 mg/kg IP) were injected to morphine-dependent mice 30 min before the naloxone injection (2mg/kg). Control mice received saline. The severity of the morphine withdrawal responses was estimated by recordeing the number of jumping and the amount of weight feces during 3o min after naloxone injection.   Results: The results showed that the extracts of VO (25 mg/kg), SH (200 mg/kg), and MP (all doses) significantly (P