Neuroprotective effects of voluntary exercise and hydroalcoholic extraction of Eriobotrya Japonica on dopamine and tyrosine hydroxylase in the striatum of parkinsonian rats

How to Cite:Zia Fallah MohammadiAkbar HajizadehmoghadamMohammad AghasiAmirhossein EsmaeiliNeuroprotective effects of voluntary exercise and hydroalcoholic extraction of Eriobotrya Japonica on dopamine and tyrosine hydroxylase in the striatum of parkinsonian rats.koomesh.15(1):e152611.

Abstract

Introduction: In this study, we investigated the effects of 12 weeks of voluntary exercise on a running wheel and extraction of plant flowers Eriobotrya Japonica on dopamine and tyrosine hydroxylase in the striatum of Parkinsonian rats. Materials and Methods: Twenty four rats were divided into three groups: control, Parkinson and Parkinson + training and extract. To induce Parkinson, 250 mg/kg of 6-hydroxy dopamine (6-OHDA) (dissolved in saline) was administered into intracerebrovenricular by a stereotaxic apparatus. Training-extract group were housed in individual cages with attached running wheels and during study period received 200 mg/kg extract intraperitoneally three times per week. Tyrosine hydroxylase and dopamine levels in the striatum were measured by ELISA. Results: Voluntary wheel running and extract significantly prevent the decrease of dopamine levels in Parkinsonian rats (P = 0.001), but tyrosine hydroxylase level did not change in training-extract group. Conclusion: Our findings show that pre-treatment with voluntary exercise and hydroalcoholic extractions of Eriobotrya Japonica have a protective role against 6-OHDA induced toxicity

Keywords

Eriobotrya japonica, Exercise Therapy, 6-hydroxydopamine, Tyrosine hydroxylase, Dopamine, Striatum, Parkinson

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