Detection of prostate cancer biomarker using optical nanobiosensor based on gold nanoparticle

How to Cite:zahra Akbari jonoushReza MansoriFatemeh yazdiyanMeisam omidiDetection of prostate cancer biomarker using optical nanobiosensor based on gold nanoparticle.koomesh.19(4):e152924.

Abstract

Introduction: Nowadays, early cancer detection and effective treatment is crucial for improved prognosis and cancer management and therefore, identification of sensitive and specific methods for early cancer detection is required. One of the methods for early cancer detection is biosensor and gold nanoparticles. The aim of this study was to examine total prostate specific antigen (PSA) biomarker using by nanobio-optical sensor. Materials and Methods: Herein, antibody coated gold nanoparticles was employed in optical immunoassay for detecting of total PSA biomarker. To achieve the goal, antibody was covalently conjugated to gold Nano spheres using 11-Mercaptoundecanoic acid (MUA). Finally, sample serum was investigated by LSPR (localized surface Plasmon resonances) and finally, the results obtained by LSPR and CLIA (Chemiluminescence assay (were compared with each other. Results: The results suggested that nano bio-optical sensor had good potential and good sensitivity in detecting of total PSA. Notably, the proposed nanobio-optical sensor delivered a good sensitivity with average sensitivity 1.1 ng/ml, and a low detection limit of o.9 ng/ml. Conclusion: These results indicate that the nnobio-optical sensor has a great potential in diagnosis of cancer biomarkers.

Keywords

Nanobio-optical Sensor

Prostate specific Antigen

Biomarker

total PSA Monoclonal Antibody

نانوزیست حسگر نوری

بیو مارکر total PSA

آنتی‌بادی مونوکلونال علیه total PSA

References

1.
Ruddon RW. Cancer Biology: Oxford University Press, USA; 2007.
2.
Madu CO, Lu Y. Novel diagnostic biomarkers for prostate cancer. J Cancer 2010; 1: 150.
3.
Linton KD, Catto JWF. Prostate cancer. Surgery (Oxford) 2013; 31: 516-522.
4.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
5.
Onsory K, Mousavi M, Haji mehdi Nouri Z, Vahabi Barzi N. Association between estrogen and progesterone receptors gene polymorphisms with prostate cancer. Koomesh 2016; 17: 455-463.
6.
Mousavi SM. Toward prostate cancer early detection in Iran. Asian Pac J Cancer Prev 2009; 10: 413-418.
7.
Doddamani D, Kayastha A. Prostate Cancer - What's New? Med J Armed Forces India 2008; 64: 51-56.
8.
Omidi M, Malakoutian M, Choolaei M, Oroojalian F, Haghiralsadat F, Yazdian F. A label-free detection of biomolecules using micromechanical biosensors. Chinese Phys Lett 2013; 30: 068701.
9.
Mascini M, Tombelli S. Biosensors for biomarkers in medical diagnostics. Biomarkers 2008; 13: 637-657.
10.
Sarkar P, Pal PS, Ghosh D, Setford SJ, Tothill IE. Amperometric biosensors for detection of the prostate cancer marker (PSA). Int J Pharm 2002; 238: 1-9.
11.
Zani A, Laschi S, Mascini M, Marrazza G. A new electrochemical multiplexed assay for PSA cancer marker detection. Electroanalysis 2011; 23: 91-99.
12.
Jang HS, Park KN, Kang CD, Kim JP, Sim SJ, Lee KS. Optical fiber SPR biosensor with sandwich assay for the detection of prostate specific antigen. Opt Commun 2009; 282: 2827-2830.
13.
Su L, Zou L, Fong CC, Wong WL, Wei F, Wong KY, et al. Detection of cancer biomarkers by piezoelectric biosensor using PZT ceramic resonator as the transducer. Biosens Bioelectron 2013; 46: 155-161.
14.
Ngundi MM, Shriver-Lake LC, Moore MH, Lassman ME, Ligler FS, Taitt CR. Array biosensor for detection of ochratoxin A in cereals and beverages. Anal Chem 2005; 77: 148-154.
15.
Omidi M, Yadegari A, Zali H, Hashemi M, Hasanzadeh H. Cancer cell detection using electrochemical nanobiosensor based on graphene / gold nanoparticle. Koomesh 2016; 18: 211-219.
16.
Willets KA, Duyne RPV. Localized surface plasmon resonance spectroscopy and sensing. Ann Rev Phys Chem 2007; 58: 267-297.
17.
Bruchez M Jr., Moronne M, Gin P, Weiss S, Alivisatos AP. Semiconductor nanocrystals as fluorescent biological labels. Science 1998; 281: 2013-2016.
18.
Pantarotto D, Partidos CD, Hoebeke J, Brown F, Kramer E, Briand JP, et al. Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses. Chem Biol 2003; 10: 961-966.
19.
Edelstein RL, Tamanaha CR, Sheehan PE, Miller MM, Baselt DR, Whitman LJ, Colton RJ. The BARC biosensor applied to the detection of biological warfare agents. Biosens Bioelectron 2000; 14: 805-813.
20.
Nam JM, Thaxton CS, Mirkin CA. Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science 2003; 301: 1884-1886.
21.
Salata OV. Applications of nanoparticles in biology and medicine. J Nanobiotechnology 2004; 2: 3.
22.
Ma J, Huifen W, Kong LB, Peng KW. Biomimetic processing of nanocrystallite bioactive apatite coating on titanium. Nanotechnology 2003; 14: 619.
23.
Molday RS, MacKenzie D. Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells. J Immunol Methods 1982; 52: 353-367.
24.
Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L. Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 1990; 175: 489-493.
25.
Tomar A, Garg G. Short review on application of gold nanoparticles. Global J Pharmacol 2013; 7: 34-38.
26.
Choi DH, Lee SK, Oh YK, Bae BW, Lee SD, Kim S, et al. A dual gold nanoparticle conjugate-based lateral flow assay (LFA) method for the analysis of troponin I. Biosens Bioelectron 2010; 25: 1999-2002.
27.
Uludag Y, Tothill IE. Cancer biomarker detection in serum samples using surface plasmon resonance and quartz crystal microbalance sensors with nanoparticle signal amplification. Anal Chem 2012; 84: 5898-5904.
28.
Majzik A, Patakfalvi R, Hornok V, Dkny I. Growing and stability of gold nanoparticles and their functionalization by cysteine. Gold Bulletin 2009; 42: 113-123.
29.
Fujiwara K, Kasaya H, Ogawa N. Gold nanoparticle monolayer formation on a chemically modified glass surface. Anal Sci 2009; 25: 241-248.
30.
Li D, He Q, Cui Y, Duan L, Li J. Immobilization of glucose oxidase onto gold nanoparticles with enhanced thermostability. Biochem Biophys Res Commun 2007; 355: 488-493.
31.
Weng G, Li J, Zhao J. Enhanced resonance light scattering of antibody covalently conjugated Gold nanoparticles due to antigen-antibody interaction induced aggregation. Nanosci Nanotechnol Lett 2013; 5: 872-878.
32.
Omidi M, Alaie S, Rousta A. Analysis of the vibrational behavior of the composite cylinders reinforced with non-uniform distributed carbon nanotubes using micro-mechanical approach. Meccanica 2012; 47: 817-833.
33.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Intern J Cancer 2010; 127: 2893-2917.
34.
Sissung TM, Price DK, Del Re M, Ley AM, Giovannetti E, Figg WD, Danesi R. Genetic variation: effect on prostate cancer. Biochim Biophys Act 2014; 1846: 446-456.
35.
Hsing AW, Chokkalingam AP. Prostate cancer epidemiology. Front Biosci 2006; 11: 1388-1413.
36.
Barry M. Clinical practice. Prostate-specific-antigen testing for early diagnosis of prostate cancer. N Engl J Med 2001; 344: 1373-1377.
37.
Ricci F, Adornetto G, Palleschi G. A review of experimental aspects of electrochemical immunosensors. Electrochim Act 2012; 84: 74-83.
38.
Holford TR, Davis F, Higson SP. Recent trends in antibody based sensors. Biosens Bioelectron 2012; 34: 12-24.
39.
Touhami A. Biosensors and nanobiosensors: design and applications. Nanomedicine 2014; 374-403.
40.
Hong Y, Huh YM, Yoon DS, Yang J. Nanobiosensors based on localized surface plasmon resonance for biomarker detection. 2012.
41.
Huang T, Nallathamby PD, Xu X-HN. Photostable single-molecule nanoparticle optical biosensors for real-time sensing of single cytokine molecules and their binding reactions. J Am Chem Soc 2008; 130: 17095-17105.
42.
Mayer KM, Lee S, Liao H, Rostro BC, Fuentes A, Scully PT, et al. A label-free immunoassay based upon localized surface plasmon resonance of gold nanorods. Acs Nano 2008; 2: 687-692.
43.
Chen S, Svedendahl M, Van Duyne RP, Kall M. Plasmon-enhanced colorimetric ELISA with single molecule sensitivity. Nano lett 2011; 11: 1826-1830.
44.
Chen S, Svedendahl M, Kll M, Gunnarsson L, Dmitriev A. Ultrahigh sensitivity made simple: nanoplasmonic label-free biosensing with an extremely low limit-of-detection for bacterial and cancer diagnostics. Nanotechnology 2009; 20: 434015.
45.
Zhou W, Ma Y, Yang H, Ding Y, Luo X. A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma. Int J Nanomed 2011; 6: 381-386.

comments