Detection of prostate cancer biomarker using optical nanobiosensor based on gold nanoparticle

authors:

avatar zahra Akbari jonoush , avatar Reza Mansori , * , avatar Fatemeh yazdiyan , avatar Meisam omidi

Koomesh: Vol.19, issue 4; 774-784
published online: December 01, 2017
article type: Research Article
received: August 07, 2016
accepted: June 01, 2017

how to cite: Akbari jonoush Z, Mansori R, yazdiyan F, omidi M. Detection of prostate cancer biomarker using optical nanobiosensor based on gold nanoparticle. koomesh. 2017;19(4):e152924. 

Abstract

Introduction: Nowadays, early cancer detection and effective treatment is crucial for improved prognosis and cancer management and therefore, identification of sensitive and specific methods for early cancer detection is required. One of the methods for early cancer detection is biosensor and gold nanoparticles. The aim of this study was to examine total prostate specific antigen (PSA) biomarker using by nanobio-optical sensor. Materials and Methods: Herein, antibody coated gold nanoparticles was employed in optical immunoassay for detecting of total PSA biomarker. To achieve the goal, antibody was covalently conjugated to gold Nano spheres using 11-Mercaptoundecanoic acid (MUA). Finally, sample serum was investigated by LSPR (localized surface Plasmon resonances) and finally, the results obtained by LSPR and CLIA (Chemiluminescence assay (were compared with each other. Results: The results suggested that nano bio-optical sensor had good potential and good sensitivity in detecting of total PSA. Notably, the proposed nanobio-optical sensor delivered a good sensitivity with average sensitivity 1.1 ng/ml, and a low detection limit of o.9 ng/ml. Conclusion: These results indicate that the nnobio-optical sensor has a great potential in diagnosis of cancer biomarkers.  

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