Application of platelet-rich plasma and other platelet-derivative products in Iranian studies

authors:

avatar Seyed Ahmad Raeissadat , avatar Marzieh Babaee , avatar Zahra Hashemi , *


how to cite: Raeissadat S A, Babaee M, Hashemi Z. Application of platelet-rich plasma and other platelet-derivative products in Iranian studies. koomesh. 2019;21(3):e153086. 

Abstract

Introduction: The use of platelet products such as platelet-rich plasma (PRP) as a component of regenerative medicine has been on the rise in Iran like other countries. We aimed to go over the current published work of Iranian researchers on platelet products, while performing qualitative and quantitative assessments about them. Materials and Methods: This study was performed as review study. The keywords “platelet rich plasma”, “growth factor”, “Iran” and the same words in Persian were used for searching electronic databases. The databases for searching were Pub Med, Scopus, Cochrane central, Google scholar, Iranmedex and Irandoc. Results: Among the 2209 studies found in the primary search, 164 articles met the set criteria. The first article had been published in 2000 and the highest number of published research was 35 in the year 2014.Animal’s experimental studies were the most common type of study (58 studies). PRP was the most researched on product (76%). From the 164 Iranian articles, 95% had been performed in university research centers. Mashhad University of medical sciences had the most published work and Shahid Beheshti University and Islamic Azad University taking the next ranks respectively. Conclusion: A rising interest in performing such studies is seen in Iran and other countries in the region. Regardless of the field of application, Turkey possesses more publications in this subject compared to Iran while Egypt and Saudi Arabia possess less published studies. It seems though, that standardizing the preparation of these products and the protocols of use is essential in reaching a common language for assessment of the performed studies

References

  • 1.

    Mason C, Dunnill P. A brief definition of regenerative medicine. Regen Med 2007; 3: 1-5.

  • 2.

    Anitua E, Snchez M, Orive G, Anda I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials 2007; 28: 4551-460.

  • 3.

    El-Sharkawy H, Kantarci A, Deady J, Hasturk H, Liu H, Alshahat M, Van Dyke TE. Platelet-rich plasma: growth factors and pro-and anti-inflammatory properties. J Periodontol 2007; 78: 661-669.

  • 4.

    Murray MM, Spindler KP, Devin C, Snyder BS, Muller J, Takahashi M, et al. Use of a collagenplatelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. J Orthop Res 2006; 24: 820-830.

  • 5.

    Abel ME, Chiu YS, Russell TR, Volpe PA. Autologous fibrin glue in the treatment of rectovaginal and complex fistulas. Dis Colon Rectum 1993; 36: 447-449.

  • 6.

    Matras H, Dinges H, Lassmann H, Mamoli B. Zur nahtlosen interfaszikulren Nerventransplantation im Tierexperiment. Wien Med Wochenschr 1972; 122: 517-523.

  • 7.

    Matras H, Dinges H, Mamoli B, Lassmann H. Non-sutured nerve transplantation: a report on animal experiments. J Maxillofac Surg 1973; 1: 37-40.

  • 8.

    Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 85: 638-646.

  • 9.

    Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101: e37-44.

  • 10.

    Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101: 299-303.

  • 11.

    Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets 2017; 1-8.

  • 12.

    Samra DJ, Orchard JW. Patterns of platelet-rich plasma use among Australasian sports physicians. BMJ Open Sport Exerc Med 2015; 1: e000054.

  • 13.

    Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trend Biotechnol 2009; 27: 158-167.

  • 14.

    Magalon J, Chateau AL, Bertrand B, Louis ML, Silvestre A, Giraudo L, et al. DEPA classification: a proposal for standardising PRP use and a retrospective application of available devices. BMJ Open Sport Exerc Med 2016; 2: e000060.

  • 15.

    Aminian B, Shams M, Omrani GR, Soveyd M. Topical autologous platelet-derived growth factors in the treatment of chronic diabetic ulcers. Arch Iran Med 2000. (Persian).

  • 16.

    Soleymani SY, Khoursand A, Motahari P, Dehghan M, SHafiee AM. Evaluation of platelet-rich plasma in combination with deproteinized bovine bone mineral in the rabbit cranium; a pilot study. J Dentist (Tehran, Iran) 2005; 2: 127-134. (Persian).

  • 17.

    Shayesteh YS, Shafiee M, Khorsand A, Dehghan M. Evaluation of platelet-rich plasma in combination with deproteinized bovine bone mineral in the rabbit cranium. Perio 2006; 4: 1-9.

  • 18.

    Khajehahmadi S. Maxillary alveolar bone grafting: the role of Platelet-rich plasma (PRF). Int J Pediatr 2014; 2: 32.

  • 19.

    Dehghan MM, Baghaban Eslaminejad M, Motallebizadeh N, Ashrafi Halan J, Tagiyar L, Soroori S, et al. Transplantation of autologous bone marrow mesenchymal stem cells with platelet-rich plasma accelerate distraction osteogenesis in A canine model. Cell J 2015; 17: 243-252.

  • 20.

    Namazi H, Mehbudi A. Investigating the effect of intra-articular PRP injection on pain and function improvement in patients with distal radius fracture. Orthop Traumatol Surg Res 2016; 102: 47-52.

  • 21.

    Namazi H, Kayedi T. Investigating the effect of intra-articular platelet-rich plasma injection on :::union:::: pain and function improvement in patients with scaphoid fracture. J Hand Microsurg 2016; 8: 140-144.

  • 22.

    Sarkarat F, Kalantar Motamedi MH, Jahanbani J, Sepehri D, Kahali R, Nematollahi Z. Platelet-rich plasma in treatment of zoledronic acid-induced bisphosphonate-related osteonecrosis of the jaws. Trauma Mon 2014; 19: e17196.

  • 23.

    Namazi H. Platelet-rich plasma as a novel therapeutic agent in osteomyelitis. Med Hypotheses 2007; 69: 706.

  • 24.

    Kazemnejad S, Najafi R, Zarnani AH, Eghtesad S. Comparative effect of human platelet derivatives on proliferation and osteogenic differentiation of menstrual blood-derived stem cells. Mol Biotechnol 2014; 56: 223-231.

  • 25.

    Behnia H, Khojasteh A, Soleimani M, Tehranchi A, Atashi A. Repair of alveolar cleft defect with mesenchymal stem cells and platelet derived growth factors: a preliminary report. J Craniomaxillofac Surg 2012; 40: 2-7.

  • 26.

    Amani M, Amirizadeh N, Soleymani M, Malekan H, Habibi RM, Bashtar M. Effect of growth factors of platelet gel on proliferation and differentiation of mesenchymal stem cells. Sci J Iran Blood Trans Organ (Khoon) 2009. (Persian).

  • 27.

    Khojasteh A, Dashti SG, Dehghan MM, Behnia H, Abbasnia P, Morad G. The osteoregenerative effects of plateletderived growth factor BB cotransplanted with mesenchymal stem cells, loaded on freezedried mineral bone block: A pilot study in dog mandible. J Biomed Mater Res B Appl Biomater 2014; 102: 1771-1778.

  • 28.

    Lafzi A, Shirmohammadi A, Faramarzi M, Jabali S, Shayan A. Clinical comparison of autogenous bone graft with and without plasma rich in growth factors in the treatment of grade II furcation involvement of mandibular molars. J Dent Res Dent Clin Dent Prospects 2013; 7: 22-26.

  • 29.

    Behnia H, Khojasteh A, Kiani MT, Khoshzaban A, Abbas FM, Bashtar M, Dashti SG. Bone regeneration with a combination of nanocrystalline hydroxyapatite silica gel, platelet-rich growth factor, and mesenchymal stem cells: a histologic study in rabbit calvaria. Oral Surg Oral Med Oral Pathol Oral Radiol 2013; 115: e7-e15.

  • 30.

    Pezeshkfar HM. Comparison of the palatal connective tissue graft as a membrane with collagen membrane in combination with Bio-Oss and PRGF for treatment of intrabony defects: a randomized clinical trial. J Dent Sch 2012; 1: 30-40. (Persian).

  • 31.

    Mogharehabed A, Birang R, Torabinia N, Nasiri S, Behfarnia P. Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study. Dent Res J 2014; 11: 460.

  • 32.

    Khojasteh A, Eslaminejad MB, Nazarian H. Mesenchymal stem cells enhance bone regeneration in rat calvarial critical size defects more than platelete-rich plasma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106: 356-362.

  • 33.

    Hashemi SS, Mahmoodi M, Rafati AR, Manafi F, Mehrabani D. The role of human adult peripheral and umbilical cord blood platelet-rich plasma on proliferation and migration of human skin fibroblasts. World J Plast Surg 2017; 6: 198-205.

  • 34.

    Alishahi MK, Mofidpoor H, Goli AA, Alishahi MAK. Histopathological evaluation of the effect of platelet-rich fibrin on canine cutaneous incisional wound healing. Iran J Veterinary Sci Technol 2013; 5: 19-32. (Persian).

  • 35.

    Asadi M, Alamdari DH, Rahimi HR, Aliakbarian M, Jangjoo A, Abdollahi A, et al. Treatment of lifethreatening wounds with a combination of allogenic plateletrich plasma, fibrin glue and collagen matrix, and a literature review. Exp Ther Med 2014; 8: 423-429.

  • 36.

    Moradi O, Ghamsari SM, Mahdi Dehghan M, Sedaghat R, Akbarein H. Effects of platelet rich plasma (PRP) and platelet rich growth factor (PRGF) on the wound healing of distal part of limbs in horses. Iran J Veterinary Surg 2013; 8: 41-48. (Persian).

  • 37.

    Jamshidzadeh A, Mardani Z, Ghahramani L, Mohammadi S, Raoufi SM, Safarpour A, et al. Topical platelet lysate hydrogel in patients with anal fissure. Ann Colorectal Res 2014; 2: e24266. (Persian).

  • 38.

    Kazemi Mehrjerdi H, Sardari K, Emami M, Movassaghi AR, Afkhami Goli A, Malekzadeh S. Efficacy of autologous platelet-rich plasma (PRP) activated by thromboplastin-D on the repair and regeneration of wounds in dogs. Iran J Veterinary Surg 2008; 3. (Persian).

  • 39.

    Malekzadeh S, Sardari K, Emami M, Kazemi Mehrjerdi H, Movassaghi AR, Afkhami Goli A. Effects of platelet-rich plasma (PRP) on cutaneous regeneration and wound healing in dogs treatedwith dexamethasone. Compar Clin Pathol 2011; 20. (Persian).

  • 40.

    Shamaei M, Taleghany F, Kiany A. Clinical evaluation of Bio-Oss alone and in combination with PRP in the treatment of grade II mandibular molar furcation defects. J Islamic Dental Assoc Iran 2007; 19: 7-12. (Persian).

  • 41.

    Aminabadi NA. Plasma rich in growth factors as a potential therapeutic candidate for treatment of recurrent aphthous stomatitis. Med Hypotheses 2008; 70: 529-531.

  • 42.

    Moradi S, Saghravanian N, Moushekhian S, Fatemi S, Forghani M. Immunohistochemical evaluation of fibronectin and tenascin following direct pulp capping with mineral trioxide aggregate, platelet-rich plasma and propolis in dogs teeth. Iran Endod J 2015; 10: 188-192.

  • 43.

    Bayani S, Masoomi F, Aghaabbasi S, Farsinejad A. Evaluation of the effect of platelet-released growth factor and immediate orthodontic loading on the removal torque of miniscrews. Int J Oral Maxillofac Implants 2016; 31: 471-477.

  • 44.

    Birang R, Torabi A, Shahabooei M, Rismanchian M. Effect of plasma-rich in platelet-derived growth factors on peri-implant bone healing: An experimental study in canines. Dent Res J 2012; 9: 93.

  • 45.

    Fahami N, Amini S. Effect of platelet rich plasma on implant stability in Mandible. J Periodontol Implant Dentist 2016; 7: 50-54. (Persian).

  • 46.

    Birang R, Tavakoli M, Shahabouei M, Torabi A, Dargahi A, Soolari A. Investigation of peri-implant bone healing using autologous plasma rich in growth factors in the canine mandible after 12 weeks: A pilot study. Open Dent J 2011; 5: 168-173.

  • 47.

    Esfahanian V, Moghaddas H, Moghaddas O. Efficacy of connective tissue as a membrane with an organic bone using platelet-rich plasma in the treatment of intrabony vertical defects. 2012. (Persian).

  • 48.

    Mansouri SS, Ghasemi M, Darmian SS, Pourseyediyan T. Treatment of mandibular molar class II furcation defects in humans with bovine porous bone mineral in combination with plasma rich in growth factors. J Dent (Tehran) 2012; 9: 41-49.

  • 49.

    Rahpeyma A. Platelet-rich plasma as filling material in open sinus lift surgery. Int J Pediatr 2014; 2: 45.

  • 50.

    Haraji A, Lassemi E, Motamedi MH, Alavi M, Adibnejad S. Effect of plasma rich in growth factors on alveolar osteitis. Natl J Maxillofac Surg 2012; 3: 38-41.

  • 51.

    Eshghpour M, Dastmalchi P, Nekooei AH, Nejat A. Effect of platelet-rich fibrin on frequency of alveolar osteitis following mandibular third molar surgery: a double-blinded randomized clinical trial. J Oral Maxillofac Surg 2014; 72: 1463-1467.

  • 52.

    Lafzi A, Chitsazi M, Farahani R, Faramarzi M. Comparative clinical study of coronally advanced flap with and without use of plasma rich in growth factors in the treatment of gingival recession. Am J Dent 2011; 24: 143-147.

  • 53.

    Lafzi A, Faramarzi M, Shirmohammadi A, Behrozian A, Kashefimehr A, Khashabi E. Subepithelial connective tissue graft with and without the use of plasma rich in growth factors for treating root exposure. J Periodontal Implant Sci 2012; 42: 196-203.

  • 54.

    Shaban B, Eshghpour M. Efficacy of Platelet-Rich Plasma in Treatment of Periodontal Defects Following Surgical Extraction of Mandibular Third Molar. IOSR Journal of Pharmacy and Biological Sciences 2015; 10: 79-82.

  • 55.

    Bagherifard A, Jabalameli M, Jahansouz A, Yahyazadeh H, Heris HK, Khezri M, et al. Platelet-rich plasma injection for symptomatic knee osteoarthritis. Shafa Orthop J 2015; 2. (Persian).

  • 56.

    Jivan SJ, Shariati-Sarabi Z, Afshari JT, Sakhmaresi TA, Monzavi S, Alamdari DH, Zargaran B. Effectiveness of intra-articular injection of platelet-rich plasma on clinical improvement of patients with knee osteoarthritis. Ann Rheum Dis 2015; 74: 1188-1194.

  • 57.

    Kalbkhani M, Dehghani S, Najafpour A, Ghorbanzadeh N. The effect of autogenous platelet rich plasma on experimentally induced osteoarthritis in rabbits stifles joint: a radiological assessment. J Animal Poult Sci 2013; 2: 27-38. (Persian).

  • 58.

    Raeissadat SA, Rayegani SM, Babaee M, Ghorbani E. The effect of platelet-rich plasma on pain, function, and quality of life of patients with knee osteoarthritis. Pain Res Treat 2013; 2013: 165967.

  • 59.

    Rayegani SM, Raeissadat SA, Taheri MS, Babaee M, Bahrami MH, Eliaspour D, Ghorbani E. Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? a randomized clinical trial. Orthop Rev (Pavia) 2014; 6: 5405.

  • 60.

    Angoorani H, Mazaherinezhad A, Marjomaki O, Younespour S. Treatment of knee osteoarthritis with platelet-rich plasma in comparison with transcutaneous electrical nerve stimulation plus exercise: a randomized clinical trial. Med J Islam Repub Iran 2015; 29: 223.

  • 61.

    Raeissadat SA, Rayegani SM, Hassanabadi H, Fathi M, Ghorbani E, Babaee M, Azma K. Knee osteoarthritis injection choices: platelet- rich plasma (PRP) versus hyaluronic acid (A one-year randomized clinical trial). Clin Med Insights Arthritis Musculoskelet Disord 2015; 8: 1-8.

  • 62.

    Raeissadat SA, Rayegani SM, Ahangar AG, Abadi PH, Mojgani P, Ahangar OG. Efficacy of intra-articular injection of a newly developed plasma rich in growth factor (PRGF) versus hyaluronic acid on pain and function of patients with knee osteoarthritis: a single-blinded randomized clinical trial. Clin Med Insights Arthritis Musculoskelet Disord 2017; 10: 1179544117733452.

  • 63.

    Forogh B, Mianehsaz E, Shoaee S, Ahadi T, Raissi GR, Sajadi S. Effect of single injection of Platelet-Rich Plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial. J Sports Med Phys Fitness 2016; 56: 901-908.

  • 64.

    Mirzatolooei F, Alamdari MT, Khalkhali HR. The impact of platelet-rich plasma on the prevention of tunnel widening in anterior cruciate ligament reconstruction using quadrupled autologous hamstring tendon: a randomised clinical trial. Bone Joint J 2013; 95-b: 65-69.

  • 65.

    Aslani H, Nourbakhsh ST, Zafarani Z, Ahmadi-Bani M, Ananloo ME, Beigy M, Salehi S. Platelet-rich plasma for frozen shoulder: a case report. Arch Bone Jt Surg 2016; 4: 90-93.

  • 66.

    Zafarani Z, Mirzaee F, Guity M, Aslani H. Clinical results of platelet-rich plasma for partial thickness rotator cuff tears: a case series. Arch Bone Jt Surg 2017; 5: 328-331.

  • 67.

    Tahririan MA, Moezi M, Motififard M, Nemati M, Nemati A. Ultrasound guided platelet-rich plasma injection for the treatment of rotator cuff tendinopathy. Adv Biomed Res 2016; 5: 200.

  • 68.

    Dehghani Nazhvani F, Tabatabaei Naeini A, Dehghani S. Evaluation of the effect of platelet rich plasma (PRP) in tendon gap healing by measuring collagen synthesis in guinea pig. Iran J Veterinary Surg 2013; 8: 23-28. (Persian).

  • 69.

    Adibmoradi M, Moradi HR, Kalantari Hesari A, Adibmoradi G. Study of histomorphometric changes in adult rats skin following injection of PRP and PPP. J Veterinary Res 2016; 71: 1-8. (Persian).

  • 70.

    Banihashemi M, Nakhaeizadeh S. An introduction to application of platelet rich plasma (PRP) in skin rejuvenation. Rev Clin Med 2014; 1: 38-43.

  • 71.

    Mehryan P, Zartab H, Rajabi A, Pazhoohi N, Firooz A. Assessment of efficacy of plateletrich plasma (PRP) on infraorbital dark circles and crow's feet wrinkles. J Cosmet Dermatol 2014; 13: 72-78.

  • 72.

    Safari M, GHorbani R, Emami M, Yousefi B, Ghahari L. The effects of GH and PDGF on the growth and proliferation of the epithelial cells. Koomesh 2008; 9: 229-235. (Persian).

  • 73.

    Manafi A. Effects of platelet-rich plasma on cartilage grafts in rabbits as an animal model. World J Plast Surg 2012; 1: 91-98.

  • 74.

    Salarinia R, Sadeghnia HR, Alamdari DH, Hoseini SJ, Mafinezhad A, Hosseini M. Platelet rich plasma: Effective treatment for repairing of spinal cord injury in rat. Acta Orthop Traumatol Turc 2017; 51: 254-257.

  • 75.

    Elahi K, Gh M. Effects of topical heterologous blood serum and bovine thrombin activated platelet rich plasma on experimental corneal stromal ulcers in rabbit. Adv Environ Biol 2012; 95-99.

  • 76.

    Khaksar E, Aldavood S, Abedi G, Sedaghat R, Nekoui O, Zamani-ahmadmahmudi M. The effect of sub-conjunctival platelet-rich plasma in combination with topical acetylcysteine on corneal alkali burn ulcer in rabbits. Comp Clin Pathol 2013; 22: 107-112. (Persian).

  • 77.

    Hesami Z, Jamshidzadeh A, Ayatollahi M, Geramizadeh B. Effect of platelet-rich plasma on CCl4-induced chronic liver injury in male rats. Int J Hepatol 2014; 2014: 932930.

  • 78.

    Moghadam A, Khozani TT, Mafi A, Namavar MR, Dehghani F. Effects of platelet-rich plasma on kidney regeneration in gentamicin-induced nephrotoxicity. J Korean Med Sci 2017; 32: 13-21.

  • 79.

    Keshvari M. The effect of autologus peripheral blood cells transplantation along with platelet rich plasma in the treatment of patients with stress incontinence. Int J Pediatr 2014; 2: 78.

  • 80.

    Fathi HR, Fereyduni F. Treatment results of combined platelet-rich plasma and fat injection in patients with velopharyngeal insufficiency. Tehran Univ Med Sci 2013; 71. (Persian).

  • 81.

    Beshkar P, Hosseini E, Ghasemzadeh M. Superior integrin activating capacity and higher adhesion to fibrinogen matrix in buffy coat-derived platelet concentrates (PCs) compared to PRP-PCs. Transfus Apher Sci 2018; 57: 76-81.

  • 82.

    Sadeghian M, Hashemibeni B, Mardani M, Amirpoor N, Aliakbari M. Comparing the effect of platelet rich plasma (PRP) and fetal bovine serum (FBS) on proliferation and survival of adipose-derived stem cells in fibrin scaffolds. J Isfahan Med School 2015; 32: 2299-2311. (Persian).

  • 83.

    Noroozi Aghideh A, Kheirandish M, Abolghasemi H, Gharehbaghian A. Platelet growth factors suppress ex vivo expansion and enhance differentiation of umbilical cord blood CD133+ stem cells to megakaryocyte progenitor cells. Growth Factors 2010; 28: 409-416.

  • 84.

    Shahidi M, Vatanmakanian M, Arami MK, Sadeghi Shirazi F, Esmaeili N, Hydarporian S, Jafari S. A comparative study between platelet-rich plasma and platelet-poor plasma effects on angiogenesis. Med Mol Morphol 2018; 51: 21-31.

  • 85.

    Khorshidi H, Raoofi S, Bagheri R, Banihashemi H. Comparison of the mechanical properties of early leukocyte- and platelet-rich fibrin versus PRGF/Endoret membranes. Int J Dent 2016; 2016: 1849207.

  • 86.

    Hashemi Tayer A, Alizadeh S, Heidari Bateni M. Efficacy of a new autologus platelet gel: in vitro study. Iran J Pediatr Hematol Oncol 2012; 2: 54-59.

  • 87.

    Yahyavi Y, Teymouri N, Amani M, Halabian R, Edalati M, Mohamadipour M, et al. Application of expired platelets in the preparation of platelet gel and study of proliferative effects of expired platelet derived growth factor on variety of cell lines 2010. (Persian).

  • 88.

    Saeedi M, Ajalloueian M, Zare E, Taheri A, Yousefi J, Mirlohi SM, et al. The effect of PRP-enriched gelfoam on chronic tympanic membrane perforation: a double-blind randomized clinical trial. Int Tinnitus J 2017; 21: 108-111.

  • 89.

    Farimani M, Poorolajal J, Rabiee S, Bahmanzadeh M. Successful pregnancy and live birth after intrauterine administration of autologous platelet-rich plasma in a woman with recurrent implantation failure: A case report. Int J Reprod Biomed (Yazd, Iran) 2017; 15: 803-806. (Persian).

  • 90.

    Zadehmodarres S, Salehpour S, Saharkhiz N, Nazari L. Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study. JBRA Assist Reprod 2017; 21: 54-56.

  • 91.

    Hosseini L, Shirazi A, Naderi MM, Shams-Esfandabadi N, Borjian Boroujeni S, Sarvari A. Platelet-rich plasma promotes the development of isolated human primordial and primary follicles to the preantral stage. Reprod Biomed Online 2017; 35: 343-350.

  • 92.

    Makarchian HR, Kasraianfard A, Ghaderzadeh P, Javadi SM, Ghorbanpoor M. The effectiveness of heparin, platelet-rich plasma (PRP), and silver nanoparticles on prevention of postoperative peritoneal adhesion formation in rats. Acta Cir Bras 2017; 32: 22-27.

  • 93.

    Rayegani SM, Raeissadat SA, Taheri MS, Babaee M, Bahrami MH, Eliaspour D, Ghorbani E. Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? Orthop Rev (Pavia) 2014; 6: 5405.

  • 94.

    Neovius E, Engstrand T. Craniofacial reconstruction with bone and biomaterials: review over the last 11 years. J Plast Reconstr Aesthet Surg 2010; 63: 1615-1623.

  • 95.

    Rezaie A, Mousavi G, Mohajeri D, Sardrodi VA. Effect of autogenous platelet-rich plasma (PRP) on femoral cancellous bone defect healing in Alloxan-induced diabetic rabbits. Aust J Basic Appl Sci 2011; 5: 800-808.

  • 96.

    Sadatmansouri S, Ayobian N, Pourseyediyan T, Saljughidarmian S. Effect of plasma rich in growth factors on the healing of intrabony defects in human: a comparative clinical trial. J Periodontol Implant Dent 2011; 2: 5-11. (Persian).

  • 97.

    Shafiei-Sarvestani Z, Oryan A, Meimandi-Parizi A, Bigham-Sadegh A. Histological, biomechanical and radiological evaluation of bone repair with human platelet rich plasma in rabbit model. Zahedan J Res Med Sci 2014; 1-6. (Perssian).

  • 98.

    Vahabi S, Yadegari Z, Mohammad-Rahimi H. Comparison of the effect of activated or non-activated PRP in various concentrations on osteoblast and fibroblast cell line proliferation. Cell Tissue Bank 2017; 18: 347-353.

  • 99.

    Khojasteh A, Kheiri L, Motamedian SR, Nadjmi N. Regenerative medicine in the treatment of alveolar cleft defect: A systematic review of the literature. J Craniomaxillofac Surg 2015; 43: 1608-1613.

  • 100.

    Tavakolinejad S, Alamdari DH, Khajehahmadi S, Khordad E, Ebrahimzadeh-bideskan A. Cleft palate reconstruction by platelet-rich-plasma and stem cell injection: Histological evidences. J Cell Anim Biol 2014; 8: 114-123.

  • 101.

    Tavakolinejad S, Hamidi Alamdari D, Khajehahmadi S, Ebrahimzadeh Bidskan A. Histological Evidences after Platelet-Rich-Plasma and Adipose Drived Stem Cells Injection on Critical Size Cleft Palate. Int J Pediatr 2014; 2: 88. (Persian).

  • 102.

    Tavakolinejad S, Khosravi M, Mashkani B, Bideskan AE, Mossavi NS, Parizadeh SMR, Alamdari DH. The effect of human platelet-rich plasma on adipose-derived stem cell proliferation and osteogenic differentiation. Iran Biomed J 2014; 18: 151. (Persian).

  • 103.

    Oryan A, Alidadi S, Moshiri A, Maffulli N. Bone regenerative medicine: classic options, novel strategies, and future directions. J Orthop Surg Res 2014; 9: 18.

  • 104.

    Tabrizi R, Karagah T, Shahidi S, Zare N. Does platelet-rich plasma enhance healing in the idiopathic bone cavity? A single-blind randomized clinical trial. Int J Oral Maxillofac Surg 2015; 44: 1175-1180.

  • 105.

    Moradi AH, Kamalinejad A, Jalilian N, Kazemi S, Khazaei M. Using PRP and human amniotic fluid combination for osteogenesis in rabbit socket preservation. Dent Hypotheses 2015; 6: 151.

  • 106.

    Oryan A, Parizi AM, Shafiei-Sarvestani Z, Bigham A. Effects of combined hydroxyapatite and human platelet rich plasma on bone healing in rabbit model: radiological, macroscopical, hidtopathological and biomechanical evaluation. Cell Tissue Bank 2012; 13: 639-651.

  • 107.

    Shafiei-Sarvestani Z, Oryan A, Bigham AS, Meimandi-Parizi A. The effect of hydroxyapatite-hPRP, and coral-hPRP on bone healing in rabbits: Radiological, biomechanical, macroscopic and histopathologic evaluation. Int J Surg 2012; 10: 96-101. (Persian).

  • 108.

    Parizi AM, Oryan A, Shafiei-Sarvestani Z, Bigham AS. Human platelet rich plasma plus Persian Gulf coral effects on experimental bone healing in rabbit model: radiological, histological, macroscopical and biomechanical evaluation. J Mater Sci Mater Med 2012; 23: 473-483.

  • 109.

    Paknejad M, Shayesteh YS, Yaghobee S, Shariat S, Dehghan M, Motahari P. Evaluation of the effect of plasma rich in growth factors (PRGF) on bone regeneration. J Dent (Tehran, Iran) 2012; 9: 59. (Persian).

  • 110.

    Oryan A, Alidadi S, Moshiri A. Platelet-rich plasma for bone healing and regeneration. Expert Opin Biol Ther 2016; 16: 213-232.

  • 111.

    Ghaffarpasand F, Dehghankhalili M, Shahrezaei M. Platele rich plasma for traumatic non-:::union::: fractures: a novel but controversial bone regeneration strategy. Bull Emerg Trauma 2013; 1: 99-101.

  • 112.

    Wang HF, Gao YS, Yuan T, Yu XW, Zhang CQ. Chronic calcaneal osteomyelitis associated with soft-tissue defect could be successfully treated with platelet-rich plasma: a case report. Int Wound J 2013; 10: 105-109.

  • 113.

    Taglialatela Scafati C, Taglialatela Scafati S, Aveta A, Cassese M, Vitale C. Chronic frontal sinus disease: combined use of platelet-rich plasma and calvarial bone grafts for sinus obliteration in aggressive and secondary cases. Rev Stomatol Chir Maxillofac 2010; 111: 216-220.

  • 114.

    Yuan T, Zhang C, Zeng B. Treatment of chronic femoral osteomyelitis with platelet-rich plasma (PRP): a case report. Transfus Apher Sci 2008; 38: 167-173.

  • 115.

    Dizaji VM, Kazemi D, Rezaei M. Influence of platelet rich fibrin on biomechanical properties of primary sutured cutaneous incisional wounds. Taiwan Veterinary J 2015; 1-6. (Persian).

  • 116.

    Ostvar O, Shadvar S, Yahaghi E, Azma K, Fayyaz AF, Ahmadi K, Nowrouzian I. Effect of platelet-rich plasma on the healing of cutaneous defects exposed to acute to chronic wounds: a clinico-histopathologic study in rabbits. Diagn Pathol 2015; 10: 85.

  • 117.

    Jamshidzadeh A, Hosseinabadi OK, Heidari R, Samani SM, Rajabzadeh S, Raoufi SM, Vadeghani AA. Wound healing activity of a new formulation from platelet lysate. Trends Pharmac Sci 2016; 2: 35-42.

  • 118.

    Tehranian A, Esfehani-Mehr B, Pirjani R, Rezaei N, sadat Heidary S, Sepidarkish M. Application of autologous platelet-rich plasma (PRP) on wound healing after caesarean section in high-risk patients. Iran Red Crescent Med J 2016; 18: e34449.

  • 119.

    Mehrabi Bahar M, Ali Akbarian M, Azadmand A. Investigating the effect of autologous platelet-rich plasma on pain in patients with pilonidal abscess treated with surgical removal of extensive tissue. Iran Red Crescent Med J 2013; 15: e6301.

  • 120.

    Tashnizi MA, Alamdari DH, Khayami ME, Rahimi HR, Moeinipour A, Amouzeshi A, Seifalian AM. Treatment of non-healing sternum wound after open-heart surgery with allogenic platelet-rich plasma and fibrin glue-preliminary outcomes. Indian J Plast Surg 2013; 46: 538-542.

  • 121.

    Alavi S, Malek F, Eshghi P, Arzhangian H. Autologous platelet-rich plasma for healing of an oncologic dehisced wound. APSP J Case Rep 2013; 4: 44.

  • 122.

    Mohammadi S, Nasiri S, Mohammadi MH, Malek Mohammadi A, Nikbakht M, Zahed Panah M, et al. Evaluation of platelet-rich plasma gel potential in acceleration of wound healing duration in patients underwent pilonidal sinus surgery: A randomized controlled parallel clinical trial. Transfus Apher Sci 2017; 56: 226-232.

  • 123.

    Karimi R, Afshar M, Salimian M, Sharif A, Hidariyan M. The effect of platelet rich plasma dressing on healing diabetic foot ulcers. Nurs Midwifery Studi 2016. (Persian).

  • 124.

    Ravari H, Hamidi-Almadari D, Salimifar M, Bonakdaran S, Parizadeh MR, Koliakos G. Treatment of non-healing wounds with autologous bone marrow cells, platelets, fibrin glue and collagen matrix. Cytotherapy 2011; 13: 705-711.

  • 125.

    Mehrannia M, Vaezi M, Yousefshahi F, Rouhipour N. Platelet rich plasma for treatment of nonhealing diabetic foot ulcers: a case report. Can J Diabetes 2014; 38: 5-8.

  • 126.

    Babaei V, Afradi H, Gohardani HZ, Nasseri F, Azarafza M, Teimourian S. Management of chronic diabetic foot ulcers using platelet-rich plasma. J Wound Care 2017; 26: 784-787.

  • 127.

    Mohammadi MH, Molavi B, Mohammadi S, Nikbakht M, Mohammadi AM, Mostafaei S, et al. Evaluation of wound healing in diabetic foot ulcer using platelet-rich plasma gel: A single-arm clinical trial. Transfus Apher Sci 2017; 56: 160-164.

  • 128.

    Afradi H, Saghaei Y, Kachoei ZA, Babaei V, Teimourian S. Treatment of 100 chronic thalassemic leg wounds by plasma-rich platelets. Int J Dermatol 2017; 56: 171-175. (Persian).

  • 129.

    Keshvari Shirvan M, Hamidi Alamdari D, Ghoreifi A. A novel method for iatrogenic vesicovaginal fistula treatment: autologous platelet rich plasma injection and platelet rich fibrin glue interposition. Int J Pediatr 2013; 2: 29. (Persian).

  • 130.

    Joudi M, Alamdari DH, Hyradfar M, Rahimi HR, Saremi E, Fathi M, et al. Lateral traumatic esophago-cutaneous fistula in a child; platelet-rich fibrin glue challenge. Iran Red Crescent Med J 2013; 15: 256.

  • 131.

    Joudi M, Alamdari DH, Rahimi HR. Successful treatment of congenital chyloperitoneum with platelet-rich fibrin glue. Iran J Pediatr 2013; 23: 357-359.

  • 132.

    Martinez-Zapata MJ, Marti-Carvajal AJ, Sola I, Exposito JA, Bolibar I, Rodriguez L, et al. Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database Syst Rev 2016; 5: CD006899.

  • 133.

    Mohammadi R, Mehrtash M, Mehrtash M, Hassani N, Hassanpour A. Effect of platelet rich plasma combined with chitosan biodegradable film on full-thickness wound healing in rat model. Bull Emerg Trauma 2016; 4: 29-37.

  • 134.

    Vahabi S, Vaziri S, Torshabi M, Esfahrood ZR. Effects of plasma rich in growth factors and platelet-rich fibrin on proliferation and viability of human gingival fibroblasts. J Dent Tehran Univ Med Sci 2015; 12: 504-512. (Persian).

  • 135.

    Shayesteh YS, Eshghyar N, Moslemi N, Dehghan MM, Motahhary P, Ghobadi Z, Golestan B. The effect of plateletrich plasma on healing of palatal donor site following connective tissue harvesting: a pilot study in dogs. Clin Implant Dent Relat Res 2010; 14: 428-433.

  • 136.

    Samani MK, Saberi BV, Ali Tabatabaei SM, Moghadam MG. The clinical evaluation of platelet-rich plasma on free gingival graft's donor site wound healing. Eur J Dent 2017; 11: 447-454.

  • 137.

    Bidar M. Evaluation of the effect of platelet-rich plasma on proliferation and differentiation of human dental pulp stem cells with or without Ga-Al-As laser. Int J Pediatr 2014; 2: 59. (Persian).

  • 138.

    Ghoddusi J, Maghsudlu A, Jafarzadeh H, Jafarian A, Forghani M. Histological evaluation of the effect of platelet-rich plasma on pulp regeneration in nonvital open apex teeth: an animal study. J Contemp Dent Pract 2017; 18: 1045-1050.

  • 139.

    Tehrani-Banihashemi A, Davatchi F, Jamshidi AR, Faezi T, Paragomi P, Barghamdi M. Prevalence of osteoarthritis in rural areas of Iran: a WHO-ILAR COPCORD study. Int J Rheum Dis 2014; 17: 384-388.

  • 140.

    Kalbkhani M, Dehghani SN, Najafpour A, Haddadi NS, Hossein KM. Research article effects of platelet rich plasma (PRP) in treatment of experimentally induced osteoarthritis in rabbits knee joint. Adv Stem Cells 2014; 2014. (Persian).

  • 141.

    Kalbkhani M, N Dehghani S, Najafpour A, Naji Hadadi S, Ghorbanzadeh N, Kalbkhani MH. The effect of PRP in repair of femoral articular cartilage notches on experimentally induced osteoarthritis rabbit. Urmia Med J 2015; 26: 215-226. (Persian).

  • 142.

    Seydi N, Dehghani S. Radiological study of the effect of Platelet Rich Plasma (PRP) on experimentally induced Osteoarthritis in Guinea Pig's stifle joint. J Animal Poul Sci 2013; 2: 74-78. (Persian).

  • 143.

    Kazemi D, Fakhrjou A. Leukocyte and platelet rich plasma (L-PRP) versus leukocyte and platelet rich fibrin (L-PRF) for articular cartilage repair of the knee: a comparative evaluation in an animal model. Iran Red Crescent Med J 2015; 17: e19594.

  • 144.

    Kazemi D, Fakhrjou A, Mirzazadeh Dizaji V, Khanzadeh Alishahi M. Effect of autologous platelet rich fibrin on the healing of experimental articular cartilage defects of the knee in an animal model. Bio Med Res Int 2014; 2014.

  • 145.

    Sadabad HN, Behzadifar M, Arasteh F, Behzadifar M, Dehghan HR. Efficacy of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: a systematic review and meta-analysis. Electron Physician 2016; 8: 2115-2122.

  • 146.

    Campbell KA, Erickson BJ, Saltzman BM, Mascarenhas R, Bach BR Jr, Cole BJ, Verma NN. Is local viscosupplementation injection clinically superior to other therapies in the treatment of osteoarthritis of the knee: a systematic review of overlapping meta-analyses. Arthroscopy 2015; 31: 2036-45 e14.

  • 147.

    Rahimzadeh P, Imani F, Faiz SH, Alebouyeh MR, Azad-Ehyaei D, Bahari L, et al. Adding intra-articular growth hormone to platelet rich plasma under ultrasound guidance in knee osteoarthritis: a comparative double-blind clinical trial. Anesth Pain Med 2016; 6: e41719.

  • 148.

    Nikvarz M, Shayestehazar M, Kariminasab MH, Sajadi M, Khalilian A, Bahari M. Effects of platelet-rich plasma in treatment of chondromalacia patella. J Mazandaran Univ Med Sci (JMUMS) 2014; 24. (Persian).

  • 149.

    Moshiri A, Oryan A, MeimandiParizi A. Synthesis, development, characterization and effectiveness of bovine pure platelet gelcollagenpolydioxanone bioactive graft on tendon healing. J Cell Mol Med 2015; 19: 1308-1332.

  • 150.

    Raeissadat SA, Sedighipour L, Rayegani SM, Bahrami MH, Bayat M, Rahimi R. Effect of platelet-rich plasma (PRP) versus autologous whole blood on pain and function improvement in tennis elbow: a randomized clinical trial. Pain Res Treat 2014; 2014: 191525.

  • 151.

    Raeissadat SA, Rayegani SM, Hassanabadi H, Rahimi R, Sedighipour L, Rostami K. Is platelet-rich plasma superior to whole blood in the management of chronic tennis elbow: one year randomized clinical trial. BMC Sports Sci Med Rehabil 2014; 6: 12.

  • 152.

    Vahdatpour B, Kianimehr L, Ahrar MH. Autologous platelet-rich plasma compared with whole blood for the treatment of chronic plantar fasciitis; a comparative clinical trial. Adv Biomed Res 2016; 5: 84.;.

  • 153.

    Nejati P, Ghahremaninia A, Naderi F, Gharibzadeh S, Mazaherinezhad A. Treatment of subacromial impingement syndrome: platelet-Rich plasma or exercise therapy? a randomized controlled trial. Orthop J Sports Med 2017; 5: 2325967117702366.

  • 154.

    Allahverdi A, Sharifi D, Abedi G, Hesaraki S, Fattahiyan H. Effect of platelet-rich plasma, low-level laser therapy (650 nm) or their combination on the healing of Achilles tendon in rabbits: a histopathological study. Eur J Exper Biol 2014; 4: 201-208. (Persian).

  • 155.

    Allahverdi A, Sharifi D, Takhtfooladi MA, Hesaraki S, Khansari M, Dorbeh SS. Evaluation of low-level laser therapy, platelet-rich plasma, and their combination on the healing of Achilles tendon in rabbits. Lasers Med Sci 2015; 30: 1305-1313.

  • 156.

    Rajabi H, Shahin HS, Norouzian M, Mehrabani D, Nazhvani SD. The healing effects of aquatic activities and allogenic injection of platelet-rich plasma (PRP) on injuries of achilles tendon in experimental rat. World J Plast Surg 2015; 4: 66-73.

  • 157.

    Oryan A, Moshiri A, Meimandi-Parizi A. Implantation of a novel tissue-engineered graft in a large tendon defect initiated inflammation, accelerated fibroplasia and improved remodeling of the new Achilles tendon: a comprehensive detailed study with new insights. Cell Tissue Res 2014; 355: 59-80.

  • 158.

    Oryan A, Moshiri A, Meimandi-Parizi A. Role of embedded pure xenogenous bovine platelet gel on experimental tendon healing, modelling and remodelling. Bio Drugs 2014; 28: 537-556.

  • 159.

    Moshiri A, Oryan A, Meimandi-Parizi A, Koohi-Hosseinabadi O. Effectiveness of xenogenous-based bovine-derived platelet gel embedded within a three-dimensional collagen implant on the healing and regeneration of the Achilles tendon defect in rabbits. Expert Opin Biol Ther 2014; 14: 1065-1089.

  • 160.

    Seyed-Forootan K, Karimi H, Dayani A-R. PRP and Metaplasia in repaired tendon. J Acute Disease 2014; 3: 284-289.

  • 161.

    Keyhan O, Hemmat S. Platelet-rich fibrin effect on increasing free fat graft survival. Int J Oral Maxillofac Surg 2011; 40: 1187.

  • 162.

    Abdali H, Hadilou M. Treatment of nasolabial fold with subdermal dissection and autologous fat injection added with platelet-rich plasma. J Res Med Sci 2014; 19.

  • 163.

    Keyhan SO, Hemmat S, Badri AA, Abdeshahzadeh A, Khiabani K. Use of platelet-rich fibrin and platelet-rich plasma in combination with fat graft: which is more effective during facial lipostructure? J Oral Maxillofac Surg 2013; 71: 610-621.

  • 164.

    Ahmadi-Ashtiani MA, Ehsani A, Rastegar H, M Hayati Salout H. Combination of herbal extracts and platelet rich plasma induced dermal papilla cells proliferation: Involvement of ERK and AKT pathway. Res Pharmaceut Sci 2012; 7: S1021. (Persian).

  • 165.

    Bagherani N. Is plateletrich plasma effective in the treatment of alopecia areata? Dermatol Ther 2016; 29: 284.

  • 166.

    Mapar MA, Shahriari S, Haghighizadeh MH. Efficacy of platelet-rich plasma in the treatment of androgenetic (male-patterned) alopecia: A pilot randomized controlled trial. J Cosmet Laser Ther 2016; 18: 452-455.

  • 167.

    Ayatollahi A, Hosseini H, Shahdi M, AhmadNasrollahi S, NassiriKashani M, Yadangi S, et al. Platelet-rich plasma by single spin process in male pattern androgenetic alopecia: is it an effective treatment? Indian Dermatol Online J 2017; 8: 460-464.

  • 168.

    Jaffary F, Nilforoushzadeh MA, Haftbaradaran E. Review on using platelet rich plasma in hair loss and hair transplantation. J Isfahan Med Sch 2014; 33: 970-982. (Persian).

  • 169.

    Ayatollahi A, Hosseini H, Gholami J, Mirminachi B, Firooz F, Firooz A. Platelet rich plasma for treatment of non-scarring hair loss: systematic review of literature. J Dermatolog Treat 2017; 28: 574-581.

  • 170.

    Faghihi G, Keyvan S, Asilian A, Nouraei S, Behfar S, Nilforoushzadeh MA. Efficacy of autologous platelet-rich plasma combined with fractional ablative carbon dioxide resurfacing laser in treatment of facial atrophic acne scars: A split-face randomized clinical trial. Indian J Dermatol Venereol Leprol 2016; 82: 162-168.

  • 171.

    Latifi N, Rezvani N, Fatemi MJ, Nourian M, Araghi S, Bagheri T. Examining the effects of platelet-rich plasma and platelet-rich fibrin on autologous full thickness skin graft survival in rats. Tehran Univ Med J TUMS Public 2016; 73: 767-777. (Persian).

  • 172.

    Kabiri A, Esfandiari E, Esmaeili A, Hashemibeni B, Pourazar A, Mardani M. Platelet-rich plasma application in chondrogenesis. Adv Biomed Res 2014; 3: 138.

  • 173.

    Ramezanifard R, Kabiri M, Hanaee Ahvaz H. Effects of platelet rich plasma and chondrocyte co-culture on MSC chondrogenesis, hypertrophy and pathological responses. EXCLI J 2017; 16: 1031-1045.

  • 174.

    Abbasipour-Dalivand S, Mohammadi R, Mohammadi V. Effects of local administration of platelet rich plasma on functional recovery after bridging sciatic nerve defect using silicone rubber chamber; an experimental study. Bull Emerg Trauma 2015; 3: 1-7.

  • 175.

    Fatemi MJ, Pakfetrat F, Akhoondinasab MR, Mansouri K, Moosavi SJ, Hosseini SA, Niazi M. The effect of sub-epineural platelet-rich plasma (PRP) on regeneration of the sciatic nerve in a rat model. Tehran Univ Med J 2016; 73: 693-699. (Persian).

  • 176.

    Salehi M, Naseri-Nosar M, Ebrahimi-Barough S, Nourani M, Khojasteh A, Farzamfar S, et al. Polyurethane/gelatin nanofibrils neural guidance conduit containing platelet-rich plasma and melatonin for transplantation of schwann cells. Cell Mol Neurobiol 2018; 38: 703-713.

  • 177.

    Bastami F, Vares P, Khojasteh A. Healing effects of platelet-rich plasma on peripheral nerve injuries. J Craniofac Surg 2017; 28: e49-e57.

  • 178.

    Pakfar A, Irani S, Hanaee-Ahvaz H. Expressions of pathologic markers in PRP based chondrogenic differentiation of human adipose derived stem cells. Tissue Cell 2017; 49: 122-130.

  • 179.

    Noroozi Aghideh A, Kheirandish M, Abolghasemi H, Gharehbaghian A. Comparison of cytokine growth factors in platelet supernatant, platelet lysate and activated platelet-rich plasma for therapeutic applications. Ann Mil Health Sci Res 2009; 7: 149-155.

  • 180.

    Najafipour F, Darejeh M, Ali MM, Najafipour F. An innovative approach to platelet-rich plasma application in military medicine; a review article. J Arch Military Med 2015; 3. (Persian).

  • 181.

    Moshiri A, Oryan A. Role of platelet rich plasma in soft and hard connective tissue healing: an evidence based review from basic to clinical application. Hard Tissue 2013; 2: 6.

  • 182.

    Nekooie-Marnany N, Jaffary F, Nilforoushzadeh MA. Platelet-rich plasma (PRP) therapy in skin rejuvenation: benefits and adverse influences. J Isfahan Med Sch 2015; 33: 1168-1185. (Persian).

  • 183.

    Gholami M, Ravaghi H, Salehi M, Yekta AA, Doaee S, Jaafaripooyan E. A systematic review and meta-analysis of the application of platelet rich plasma in sports medicine. Electron Physician 2016; 8: 2325-2332.

  • 184.

    Beitzel K, Allen D, Apostolakos J, Russell RP, McCarthy MB, Gallo GJ, et al. US definitions, current use, and FDA stance on use of platelet-rich plasma in sports medicine. J Knee Surg 2015; 28: 29-34.

  • 185.

    Park YG, Han SB, Song SJ, Kim TJ, Ha CW. Platelet-Rich Plasma Therapy for Knee Joint Problems: Review of the Literature, Current Practice and Legal Perspectives in Korea. Knee Surg Relat Res 2012; 24: 70-78##.