Protective effect of resveratrol against sub-acute diazinon-induced oxidative stress in rat kidney

hosseinrahbari, amir; nazem, habibollah; Fazilati, Mohammad; Mehri, Fereshteh

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Koomesh

Journal of Semnan University of Medical Sciences

e-ISSN 2345-3699

p-ISSN 1608-7046

Cover image of the article: Protective effect of resveratrol against sub-acute diazinon-induced oxidative stress in rat kidney

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Outline

Abstract
References
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Protective effect of resveratrol against sub-acute diazinon-induced oxidative stress in rat kidney

Authors

amir hosseinrahbari, habibollah nazem, Mohammad Fazilati, Fereshteh Mehri

^,*

*Corresponding Author: Email: freshteh_mehri@yahoo.com

Koomesh:Vol. 23, issue 6; 794-800

Published online:Dec 02, 2021

Article type:Research Article

Received:Nov 02, 2020

Accepted:Jun 02, 2021

How to Cite:hosseinrahbari A, nazem H, Fazilati M, Mehri F. Protective effect of resveratrol against sub-acute diazinon-induced oxidative stress in rat kidney. koomesh. 2021;23(6):e153313. doi:

Abstract

Introduction: Diazinon is used as an organophosphate pesticide in agriculture. Studies showed that a lot of organophosphates can produce free radicals and disrupt antioxidant system. Resveratrol as an antioxidant can reduce oxidative stress in kidney tissue. The study aimed to investigate the protective role of resveratrol on oxidative stress induced by sub-acute diazinon exposure in kidney tissue of rats. Materials and Methods: Twenty-eight Wistar rats were randomly divided into 4 groups: control, diazinon (70 mg/kg), diazinon (70 mg/kg) + resveratrol (5 mg/kg), diazinon (70 mg/kg) + resveratrol (10 mg/kg) groups. The treatments were administered by gavage daily for four weeks. Urine samples were collected 24 hours after the last dose. The rats were anesthetized with ether and 3 mL of blood samples was taken from animals. Diazinon level in urine was measured using HPLC. The serum level of creatinine, urea, protein, malondialdehyde (MDA), and total antioxidant activity (TAC) were evaluated by biochemical methods. Results: The results showed that the diazinon level in the diazinon group was significantly higher than that of the diazinon (70 mg/kg) + resveratrol group (5 and 10 mg/kg) (P

KeywordsDiazinon Kidney Resveratrol Oxidative Stress دیازینون کلیه رزوراترول استرس اکسیداتیو

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Copyright

© 2021, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

Outline

Protective effect of resveratrol against sub-acute diazinon-induced oxidative stress in rat kidney

Abstract

References

Copyright

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