Effects of alcoholic extract of Zingiber officinalis rhizome on acute and chronic inflammation and pain in rats

How to Cite:Mohsen KhaliliZahra KiaSalariEhsan FarhadiMahshid AgahEffects of alcoholic extract of Zingiber officinalis rhizome on acute and chronic inflammation and pain in rats.koomesh.12(2):e153813.

Abstract

Introduction: Patients with chronic, painful diseases often seek alternative therapy. The rhizome of Zingiber (Z) officinalis is a common constituent of diets around the world and its extracts have been reported to exhibit several pharmacological activities. We investigated the effects of alcoholic Zingiber oficinalis rhizome extract on two different models of acute and chronic inflammation and pain. Material and Methods: Formalin, xylen and acetic acid were used to induce acute inflammation in paw, ear and peritoneum, respectively. The amount of Evans' blue dye leakage into these tissues was used as an index of acute inflammation . For chronic inflammation, a piece of sterile cotton (30 mg) was impalnated into the groin region for a period of seven days. Following, t he weight of the cotton piece before implantation is subtracted from the weight of the dried piece and used as an index of chronic inflammation. Finally, acute and chronic pain assessment was carried out via the formalin test protocol . Results: In acute inflammation model, the formalin-induced inflammation in paw and peritoneum was significantly (P

Keywords

Inflammation, Pain, Alcoholic extract, Zingiber oficinalis, Rats

التهاب، درد، عصاره الکلی زنجبیل، موش صحرایی

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