Occult HBV Infection among Chronic Hepatitis C Patients

R Aghazadeh; Honarkar; SM Alavian; Sh Samiee; K Saeedfar; M Baladast; MJ Ehsani; AH Mohammadali Zadeh; A Nori Nayer; MR Zali

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Occult HBV Infection among Chronic Hepatitis C Patients

Author(s):

R Aghazadeh¹,

Honarkar^2,*,

SM Alavian³,

Sh Samiee⁴,

K Saeedfar⁵,

M Baladast⁵,

MJ Ehsani¹,

AH Mohammadali Zadeh⁶,

A Nori Nayer⁶,

MR Zali⁷

1Department of Gastroenterology, Taleghani Hospital, Tehran, Iran

2Gastroenterologist, Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

3Associate Professor of Gastroenterology, Department of Internal Medicine, Baqiatollah Medical University; Head of Tehran Hepatitis Center, Tehran, Iran

4Iran Blood Transfusion Organization, Tehran, Iran

5Research Fellow, Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

6Assistant Professor of Gastroenterology, Department of Gastroenterology, Taleghani Hospital, Tehran, Iran

7Professor of Gastroenterology, Department of Gastroenterology, Taleghani Hospital, Head of Research Center of Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Shiraz E-Medical Journal:Vol. 7, issue 2; 1-6

Published online:Apr 01, 2006

Article type:Research Article

How to Cite:R Aghazadeh HonarkarSM AlavianSh SamieeK SaeedfarM BaladastMJ EhsaniAH Mohammadali ZadehA Nori NayerMR Zaliet al.Occult HBV Infection among Chronic Hepatitis C Patients.Shiraz E-Med J.7(2):20372.

Abstract

Transmission routs of both hepatitis B and hepatitis C viruses are similar and infection with both viruses is common. Occult hepatitis B is a new entity in which serum HBsAg is negative but HBVDNA is detectable in serum or liver tissues. In this study the frequency of occult hepatitis B among patients with chronic hepatitis C and also their biochemical and histological changes were investigated. In this study, 27 patients with chronic hepatitis C with negative serum HBsAg were enrolled. These patients had been referred to Taleghani hospital and RCGLD (Research Center for Gastroenterology and Liver Diseases) or THC (Tehran Hepatitis Center) during years 2001 and 2002 and had been undertaken liver biopsy. Liver biopsies were reviewed and hepatitis B virus (HBV) DNA and HBsAg and HBcAg were assayed in liver tissue by polymerase chain reaction (PCR) and immunohistochemistry (IHC) respectively. From 27 chronic hepatitis C patients studied, HBVDNA was detectable by PCR in 5(19%). Immunohistochemistry for both HBcAg and HBsAg were reported to be negative in all patients. Histological changes of cirrhosis and symptoms of decompensated cirrhosis were seen just in HBVDNA positive patients. This study concludes that Occult HBV infection is common among chronic hepatitis C patients. Occult hepatitis B probably accelerates the evolution to cirrhosis in patients with chronic hepatitis C.

Keywords

Chronic hepatitis B

Chronic hepatitis C

Chronic liver diseases

HBVDNA

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