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Occult HBV Infection among Chronic Hepatitis C Patients
Authors
R Aghazadeh1, Honarkar2,*, SM Alavian3, Sh Samiee4, K Saeedfar5, M Baladast5, MJ Ehsani1, AH Mohammadali Zadeh6, A Nori Nayer6, MR Zali7
1Department of Gastroenterology, Taleghani Hospital, Tehran, Iran
2Gastroenterologist, Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
3Associate Professor of Gastroenterology, Department of Internal Medicine, Baqiatollah Medical University; Head of Tehran Hepatitis Center, Tehran, Iran
4Iran Blood Transfusion Organization, Tehran, Iran
5Research Fellow, Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
6Assistant Professor of Gastroenterology, Department of Gastroenterology, Taleghani Hospital, Tehran, Iran
7Professor of Gastroenterology, Department of Gastroenterology, Taleghani Hospital, Head of Research Center of Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, 7th floor, Taleghani Hospital, Tabnak St., Evin, Tehran, Iran., article@rcgld.org. Tel: 2417283. Fax: 2402639. Email: article@rcgld.org
Published online:Apr 01, 2006
Article type:Research Article
How to Cite:Aghazadeh R, Honarkar , Alavian S, Samiee S, Saeedfar K, et al. Occult HBV Infection among Chronic Hepatitis C Patients. Shiraz E-Med J. 2006;7(2):20372. doi:
Abstract
Transmission routs of both hepatitis B and hepatitis C viruses are similar and infection with both viruses is common. Occult hepatitis B is a new entity in which serum HBsAg is negative but HBVDNA is detectable in serum or liver tissues. In this study the frequency of occult hepatitis B among patients with chronic hepatitis C and also their biochemical and histological changes were investigated. In this study, 27 patients with chronic hepatitis C with negative serum HBsAg were enrolled. These patients had been referred to Taleghani hospital and RCGLD (Research Center for Gastroenterology and Liver Diseases) or THC (Tehran Hepatitis Center) during years 2001 and 2002 and had been undertaken liver biopsy. Liver biopsies were reviewed and hepatitis B virus (HBV) DNA and HBsAg and HBcAg were assayed in liver tissue by polymerase chain reaction (PCR) and immunohistochemistry (IHC) respectively. From 27 chronic hepatitis C patients studied, HBVDNA was detectable by PCR in 5(19%). Immunohistochemistry for both HBcAg and HBsAg were reported to be negative in all patients. Histological changes of cirrhosis and symptoms of decompensated cirrhosis were seen just in HBVDNA positive patients. This study concludes that Occult HBV infection is common among chronic hepatitis C patients. Occult hepatitis B probably accelerates the evolution to cirrhosis in patients with chronic hepatitis C.
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Copyright
© 2006, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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