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Bone Mineral Density in Iranian Female patients with Rheumatoid Arthritis

Author(s):
Z Zakeri Z Zakeri *,+


Shiraz E-Medical Journal:Vol. 11, issue 3; 20391
Published online:Jul 01, 2010
Article type:Research Article
Received:May 30, 2009
Accepted:Mar 05, 2010
How to Cite:Z Zakeri Bone Mineral Density in Iranian Female patients with Rheumatoid Arthritis.Shiraz E-Med J.11(3):20391.

Abstract

Background:

Patients with rheumatoid arthritis (RA) are at increased risk of developing low bone mineral density. The aim of the present study was to compare the bone mineral density of Iranian female RA patients with healthy controls.

Materials and methods:

In this case-control study, bone mineral density of 391 rheumatoid arthritis patients and 391 healthy controls referred during a 4-year period (2003-2007) to Imam Khomeini Hospital in Tehran, were studied. Patients were assigned in two subgroups; group 1 (n=184) with a history of current oral corticosteroid use and group 2 (n=207) with-out corticosteroid use. Dual-energy x-ray absorptiometry technique was used to measure bone density. Differences between groups were analyzed using Fisher's exact test. Duncan test and Schaffer test were used to compare mean difference between each two groups.

Results:

Among ?45 and >60 years females, bone density did not show a significant differ-ence at lumbar region between the 3 groups, however, the differences at femoral neck were statistically significant (p

Conclusion:

Low bone density in Iranian female patients with RA is in accordance with west-ern societies. Among RA female patients the risk of BMD reduction is increased by age and partly by oral glucocorticoids. Therefore, routine BMD evaluation is strongly suggested for RA patients.

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