Gastrin, Cholecystokinin (CCK) and H. Pylori in Nonulcer Dyspepsia.


avatar Z Honarkar * , +

how to cite: Honarkar Z. Gastrin, Cholecystokinin (CCK) and H. Pylori in Nonulcer Dyspepsia.. Shiraz E-Med J.8(1):20433.



One of the etiological causes of nonulcer dyspepsia (NUD) is H. pylori infection. The role of H. pylori infection in dyspepsia and its accompaniment with hormonal disorders remain controversial. We studied the association between existence of H. pylori and variation of Colecystokinin (CCK) and gastrin in NUD patients.


One hundred consecutive out patients with NUD that referred to Taleghani Hospital in Tehran from May 2002 to January 2003 were studied. Demographic and clinical examinations were fulfilled and basal serum gastrin and CCK level and IgG anti H. pylori were measured. After through endoscopic evaluation, gastric mucosal biopsies were taken from all patients for investigation of H. pylori (Rapid urease test (R.U.T), direct exam and IgG Anti H. pylori tests) and histological assessment.


100 NUD patients including 48 (48%) male and 52(52%) female were studied. 11 patients were smoker. Fullness (62%) was the predominant symptoms in them. 59% of patients complained of abdominal pain, 57% of early satiety, 42% of anorexia, 17% of dysphagia, 46% of nausea and 20% of vomiting. 78 (78%) of patients were H. Pylori positive. In H. pylori positive group, the mean SD of CCK was 1.06 0.40 and gastrin was 6.68 7.82. In H. pylori negative group the mean SD of CCK was 0.92 0.31 and gastrin 8.20 12.58. There was no significant difference in gastrin and CCK serum level between H. pylori positive and H. pylori negative in nonulcer dyspeptic patients.


According to high frequency of H. pylori in NUD patients, the investigation of patients for the presence of H. pylori in patients is recommended. We didn't find any relation between H. pylori infection and the serum level of gastrin and CCK in NUD patients.

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