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Prevention of hypotension during spinal anesthesia for cesarean section avoids maternal and fetal side effects. The aim of this study was to compare the effects of the com-bination of ephedrine crystalloid and prehydration with crystalloid alone on maternal blood pressure and neonatal outcome during cesarean section under spinal anesthesia.
We enrolled 72 full term women weighing between 50 and 75 Kg, classified as ASA I, scheduled for elective caesarean section under spinal anesthesia. Participants were ran-domly allocated to either the ephedrine or crystalloid group. After arrival in the operating room and intravenous (IV) access, 10 ml/Kg of ringer solution was infused 10-15 minutes before the initiation of the spinal block, but in the ephedrine group, an additional 10mg of ephedrine was added to the solution for infusion. In the crystalloid group, a placebo was added to the solution.
Hypotension occurred in 55.6% of patients in the crystalloid group and in 25% of patients in the ephedrine group. The difference between the two groups was found to be statistically significant (P = 0.008), however, there was no significant difference in mean systolic blood pressure between the two groups (105.61 7.13 in crystalloid group vs. 107.89 9.84 in ephedrine group). Apgar scores in newborns were above 8 in both groups.
Prophylactic ephedrine given by infusion in combination with crystalloid was more effective than crystalloid prehydration in the prevention of hypotension during spinal anesthesia for elective caesarean section.
© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Gousheh MR, Akhondzade R, Asl Aghahoseini H, Olapour A, Rashidi M. The Effects of Pre-Spinal Anesthesia Administration of Crystalloid and Colloid Solutions on Hypotension in Elective Cesarean Section. Anesth Pain Med. 2018;8(4):e69446. doi: https://doi.org/10.5812/aapm.69446
Khamis AM, Abd El-Aziz AEA, Hasan Mostafa R, Noser MA. Ephedrine Versus Ondansetron in the Prevention of Hypotension During Cesarean Section: A Randomized, Double Blind, Placebo-Controlled Trial: Spinal induced hypotension in parturients. J Cell Mol Anesth. 2022;7(3):e150196. doi: https://doi.org/10.22037/jcma.v7i3.37841
R M, V S. A Study of Phenylephrine Administration for the Prevention and Treatment of Hypotension in Cesarean Section during Spinal Anaesthesia. J Cell Mol Anesth. 2021;6(3):e150253. doi: https://doi.org/10.22037/jcma.v6i3.34213
Hassani V, Movaseghi G, Safaeeyan R, Masghati S, Ghorbani Yekta B, et al. Comparison of Ephedrine vs. Norepinephrine in Treating Anesthesia-Induced Hypotension in Hypertensive Patients: Randomized Double-Blinded Study. Anesth Pain Med. 2018;8(4):e79626. doi: https://doi.org/10.5812/aapm.79626
Nikooseresht M, Seifrabiei MA, Hajian P, Khamooshi S. A Clinical Trial on the Effects of Different Regimens of Phenylephrine on Maternal Hemodynamic After Spinal Anesthesia for Cesarean Section. Anesth Pain Med. 2020;10(4):e58048. doi: https://doi.org/10.5812/aapm.58048
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