Effect of Inflammatory Factors on ?2-Microglobulin in Hemodialysis Patients

Maryam Rahbar; Baharak Mehdipour-Aghabagher

Abstract

Introduction:

Systemic inflammation is a common complication in patients with chronic renal dysfunction including hemodialysis patients. The aim of this study is evaluating association of inflammatory factors on ?2-microglobulin (?2-m) in hemodialysis patients

Materials and Methods:

This is a single-center prospective study conducted on 39 hemodialysis patients in Sina hospital in 2009. All cases had well-functioning arteriovenous (AV) access or permanent venous catheter and were dialyzed thrice weekly. All patients were hemodialyzed using low flux membranes and Ferzinuce system. Blood samples were taken from the arterial line for the following assessments: Hct, hemoglobin, WBC, platelets, erythrocyte sedimentation rate (ESR), blood urea and serum creatinine, HDL cholesterol (HDL-C), total protein, albumin, CRP, and ?2- microglobulin. The statistical analyses were performed using Chi-square test for relationships. All tests were two-tailed and with P < 0.05 were considered significant.

Results:

The cases included 28 females (71.8%) and 11 males (28.2%) with the mean age of 60.61 15.25 yrs. There was no significant relationship between CRP, HDL-C, Albumin and ?2-microglobulin (P ? 0.05).

Conclusion:

Although the rise of inflammatory factors may increase ?2-microglobulin levels, we found no significant relationship between inflammatory factors and ?2-microglobulin when low-flux biocompatible membranes are used.

Keywords

Hemodialysis b2-Microglobulin CRP HDL Cholesterol Albumin

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