Logo

Prospective Randomized Trial of Esomeprazole versus Lansoprazole and Omeprazole Based Triple Therapy for H. Pylori Eradication in an Iranian Population

Author(s):
Abdol Rahim  MasjedizadehAbdol Rahim Masjedizadeh1,*, Eskandar  HajianiEskandar Hajiani1, Jalal  HashemiJalal Hashemi1, Ali Akbar  ShayestehAli Akbar Shayesteh1, Somieh  SadrneshinSomieh Sadrneshin2
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ah-waz Jundishapur University of Medical Sciences, Ahwaz, Iran
2Research Institute for Infectious Diseases of Digestive system and Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran


Shiraz E-Medical Journal:Vol. 13, issue 4; 15-168
Published online:Oct 01, 2012
Article type:Research Article
Received:May 11, 2011
Accepted:Dec 24, 2012
How to Cite:Abdol Rahim MasjedizadehEskandar HajianiJalal HashemiAli Akbar ShayestehSomieh SadrneshinProspective Randomized Trial of Esomeprazole versus Lansoprazole and Omeprazole Based Triple Therapy for H. Pylori Eradication in an Iranian Population.Shiraz E-Med J.13(4):15-168.

Abstract

Background:

Although triple therapy with one proton pump inhibitor (PPI) and two antibiotics for one week has been introduced as the treatment of choice, quadruple therapy in Iran is the standard treatment due to the organisms high resistance is related to Helicobacter pylori (H. pylori) organism.

Objective:

Comparison of three different PPIs; esomeprazole, lansoprazole and omeprazole with a longer duration (10 days) for eradication of H. pylori in the Iranian population.

Materials and Methods:

Two-hundred ninety-four patients with endoscopic evidence of peptic ulcer, non-ulcer dyspepsia, gastritis or acid reflux and confirmed H. pylori, either by histology or a positive urea test were randomly divided into three groups; namely, group I (98 patients) received omeprazole, clarithromycin and amoxicillin (OCA); group II (97 patients) received lansoprazole (LCA) and group III (98 patients) received esomeprazole (NCA) instead of ome-prazole.Response to treatment was defined as eradication of H. pylori confirmed by negative C14 urea breath test 40 days after treatment course completion.

Results:

Per protocol (PP) eradication rate of H. pylori was 91.9 % for group I, 80.4 % for group II and 91.8 % for group III (P = 0.017). Intention to treat (ITT) eradication rate for groups I, II and III were 91 %, 78 % and 90 %, respectively (P = 0.012). The patients compliance was 99 %, 97 % and 98 % and the adverse events were 36 %, 35 % and 14 % in these three groups, respectively (P = 0.614) (P = 0.001). Based on age and sex, eradication rate showed significant difference without considering various treatment protocols (P = 0.017 and 0.031, respectively). There was no difference in eradication rate between PUD and NUD patients (P = 0.166).

Conclusions:

Both PP and ITT eradication rates were higher in the OCA and NCA treatment groups. Group III had the least adverse effects. Eradication by NCA regimen had less side ef-fects but more cost compared to OCA regimen

Keywords

Full Text

Full text is available in PDF

comments

Leave a comment here

Share on
Metrics

Purchasing Reprints

  • Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here (   https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.
Search Relations

Author(s):

Related Articles