The Effect of Fruit Pod Powder and Aquatic Extract of Prosopis farcta on Healing Cutaneous wounds in Diabetic Rat

Azadeh Ranjbar-Heidari; Jina Khaiatzadeh; Naser Mahdavishahri; Maryam Tehranipoor

Zahedan Journal of Research in Medical Sciences

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The Effect of Fruit Pod Powder and Aquatic Extract of Prosopis farcta on Healing Cutaneous wounds in Diabetic Rat

Author(s):

Azadeh Ranjbar-Heidari¹,

Jina Khaiatzadeh^1,*,

Naser Mahdavishahri²,

Maryam Tehranipoor³

1Department of Developmental Zoology, science Faculty, Mashhad branch, Islamic Azad University, Mashhad, Iran

2Department of Histology, Mashhad branch, Islamic Azad University, Mashhad, Iran

3Department of Animal Physiology, Mashhad branch, Islamic Azad University, Mashhad, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 14, issue 5; e93444

Published online:May 28, 2012

Article type:Research Article

Received:Jul 16, 2011

Accepted:Aug 29, 2011

How to Cite:Azadeh Ranjbar-HeidariJina KhaiatzadehNaser MahdavishahriMaryam TehranipoorThe Effect of Fruit Pod Powder and Aquatic Extract of Prosopis farcta on Healing Cutaneous wounds in Diabetic Rat.Zahedan J Res Med Sci.14(5):e93444.

Abstract

Background: Wound healing in diabetes is one of the challenges in the medical science. Accordingly, new quick wound-healing compounds are welcomed. It is likely that Prosopis farcta - indigenous to southeastern Iran – accelerates regenerating process for its anti-inflammatory, antimicrobial and antidiabetic effects. This study is aimed at examining the local effect of the fruit dusk powder and root extract of Prosopis farcta on diabetic healing.
Materials and Methods: Twenty-four male Wistar rats were randomly divided into 4 groups of intact, diabetic control, Experimental group 1(diabetic treated with fruit powder) and Experimental group 2 (diabetic treated with root extract). Diabetic groups were injected streptozotocin (STZ). Then, three holes (4 mm diameter) were made on both dorsal sides of the rats in all groups. Experimental groups were treated by fruit dusk powder and the plant root aquatic extract and the control groups were treated by normal saline. The area of the holes was continuously measured till they were completely closed.
Results: In the treatment groups using fruit dusk powder and plant root aquatic extract, the hole area had significantly decreased (p< 0.05).
Conclusion: It Seems that local administration of Prosopis farcta fruit dusk powder and root aquatic extract probably accelerates healing in diabetic rats. Regarding the antidiabetic, anti-inflammatory and healing effects of this plant, we are hopeful that Prosopis farcta plant finds an appropriate status in traditional medicine and pharmacology.

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