Effects of Dietary Approaches to Stop Hypertension (DASH) Eating Plan on Inflammation and Liver Functional Tests among Type 2 Diabetic Patients

Leila Azadbakht; Azam Borzoi; Ahmad Esmaillzadeh

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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Effects of Dietary Approaches to Stop Hypertension (DASH) Eating Plan on Inflammation and Liver Functional Tests among Type 2 Diabetic Patients

Author(s):

Leila Azadbakht^1,*,

Azam Borzoi²,

Ahmad Esmaillzadeh¹

1Associate Professor of Nutrition, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

2BSc of Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 14, issue 2; e93573

Published online:Feb 08, 2012

Article type:Research Article

Received:Apr 26, 2011

Accepted:Jun 08, 2011

How to Cite:Leila AzadbakhtAzam BorzoiAhmad EsmaillzadehEffects of Dietary Approaches to Stop Hypertension (DASH) Eating Plan on Inflammation and Liver Functional Tests among Type 2 Diabetic Patients.Zahedan J Res Med Sci.14(2):e93573.

Abstract

Background : Considering that the new cardiovascular risk factors are important among type 2 diabetes. We evaluated the effects of the Dietary Approaches to Stop Hypertension (DASH) eating pattern on inflammation and novel cardiovascular risk factors in type 2 diabetic patients.

Materials and Method : In this eight-weeks crossover randomized clinical trail, 31 type 2 diabetic patients were on a control diet or the DASH diet. Fruits, vegetables, whole grains, low-fat dairy products are consumed in high amounts in this diet. However, saturated fat, total fat, cholesterol, refined grains, and sweets are recommended in low amounts. DASH diet had a total of 2,400 mg sodium per day. There was a four week washout between two trial phases. C-reactive protein level, coagulation indices and hepatic function tests were measured at baseline and after each phase of trial.

Results : The mean percent change for plasma C-reactive protein level was -26.9±3.5% after the DASH diet and

-5.1±3.8% after the control diet (p=0.001). Both alanine aminotransferase and aspartate aminotransferase levels were significantly reduced after consuming the DASH diet compared to the control diet (-14.8±3.0 % vs -6.6±3.4% p=0.001, -29.4±3.7% vs -5.9±1.4% p=0.001, respectively). The DASH diet reduced the plasma fibrinogen level compared to the control diet (-11.4±3.6% and 0.5±3.4% p=0.03, respectively).

Conclusion : Among diabetic patients, the DASH diet can play an important role in reducing inflammation, plasma levels of fibrinogen and liver aminotranferases. Future long-term studies are recommended . [ZJRMS, 2012 14(2): 9-15 ]

Keywords

Diet

Liver enzymes

Diabetes type 2

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