Effect of Different Intensities of Short Term Aerobic Exercise on Expression of miR-124 in the Hippocampus of Adult Male Rats

Shima Mojtahedi; MohammadReza Kordi; Masoud Soleimani; seyed ebrahim hosseini

Zahedan Journal of Research in Medical Sciences

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Effect of Different Intensities of Short Term Aerobic Exercise on Expression of miR-124 in the Hippocampus of Adult Male Rats

Author(s):

Shima Mojtahedi^1,*,

MohammadReza Kordi²,

Masoud Soleimani³,

seyed ebrahim hosseini⁴

1MSc of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.

2Associate professor of Exercise Physiology, School of Physical Education and Sport Science, University of Tehran, Tehran, Iran.

3Assistant professor of Hematology, Tarbiat Modares University, Tehran, Iran.

4MSc of Exercise Physiology, Sabzevar Islamic Azad University,Razavi Khorasan, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 14, issue 2; e93575

Published online:Feb 29, 2012

Article type:Research Article

Received:Jan 26, 2012

Accepted:Feb 08, 2012

How to Cite:Shima MojtahediMohammadReza KordiMasoud Soleimaniseyed ebrahim hosseiniEffect of Different Intensities of Short Term Aerobic Exercise on Expression of miR-124 in the Hippocampus of Adult Male Rats.Zahedan J Res Med Sci.14(2):e93575.

Abstract

Background: One of the most specific miRNA of the brain is miR-124 which has been detected in the hippocampal area. This microRNA through suppression of some target genes, cause the stem cell to be changed into the neuron. The aim of this study was to identify the effect of exercise intensity on the expression of miR-124.

Materials and Method: Eighteenadult male Wistar rats were selected as subjects. The animals randomly divided into 3 groups of control (n=6) and runner (n=6). In low intensity group (n=6) animals daily, were allowed to run on treadmill with an intensity of about 35-40% of maximum oxygen consumption, daily for 30 minutes, of 2 weeks period. In high intensity group (n=6) the subjects were run in the same conditions but with an intensity of about 70-75% maximum oxygen consumption. After 24 hours of the last session of exercise, the animals were killed. Changes in expression analyzed using the quantitave RT-PCR technique.

Results: Statistical analysis by one-way ANOVA showed a statistically significant association between the intensities of exercise and elevated expression of miR-124 in the exercise group at significant level of p≤0.05.

Conclusion: To sum up, expression of miR-124, in the hippocampus of adult rats, is associated with exercise intensity and running forcefully in comparison with lower intensity, in which leads to robust changes in some mechanisms that involve in exercise- induced neurogenesis. [ZJRMS, 2012 14(2): 16-20]

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