Use of random urinary protein-to-creatinine ratio for diagnosis of significant proteinuria during pregnancy

M Mokhtari; Ali Reza Dashipour; F Ziaeian

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

Current Issue All Issues In Press Articles Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

Use of random urinary protein-to-creatinine ratio for diagnosis of significant proteinuria during pregnancy

Author(s):

M Mokhtari^1,*,

Ali Reza Dashipour²,

F Ziaeian³

1Obstetric and Gynecology Dept, Faculty of Medicine, Zahedan University of Medical Sciences and health services, Zahedan, Iran.

2Nutrition Dept, Faculty of Health, Zahedan University of Medical Sciences and health services, Zahedan, Iran

3Assistant of Gynecology Dept, Faculty of Medicine, Zahedan University of Medical Sciences and health services, Zahedan, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 7, issue 4; e94921

Published online:Sep 20, 2005

Article type:Research Article

Received:Feb 22, 2004

Accepted:Jul 11, 2005

How to Cite:M MokhtariAli Reza DashipourF ZiaeianUse of random urinary protein-to-creatinine ratio for diagnosis of significant proteinuria during pregnancy.Zahedan J Res Med Sci.7(4):e94921.

Abstract

Background: Sience the gold standard test used for making the diagnosis of significant
proteinuria in 24-hours urine collection is cumbersome and time-consuming. It is necessity to
substitute it with a rapid method.
Methods and Materials: In this descriptive- analytic study 140 were selected for evaluation of
pre-eclampsia in Zahedan Qods hospital in year 2003. A random urine samples was taken from
each for the determination of protein-to-creatinine ratio and a 24-hour urine sample was sent to the
laboratory as the gold standard method for the determination of clear proteinuria, the sensitivity,
specificity and the positive and negative predictive value of the random protein-to-creatinine ratio
was determined with a range of cut offs. The association between two methods was determined with
Pearson correlation coefficient.
Results: The correlation coefficient between the two methods was r=0.807, which showed high
correlation of them. The data suggest that the best cutoff of ≥ 0.21 is a good predictor of significant
proteinuria. This cutoff yields sensitivity, specificity and also the negative and positive predictive
value of 100%.
Conclusions: This study showed, the random urinary protein-to-creatinine ratio could replace the
24-hour urine collection as a simpler, faster, more useful method for the diagnosis of significant
proteinuria.

Keywords

Pre-eclampsia

Urine protein-to-creatinine ratio

significant proteinuria

24-hour urine collection

cut off point

Fulltext

The full text of this article is available on the PDF file.

References

1.
The References of this article are available on the PDF file.

comments