The student community in Iran constitutes a significant portion of the whole population of the country and the number of students is increasing every year; hence, the issue of student health became important more than ever (
1). In this regard, it is of high importance to pay attention to medical science students who are responsible for the future health of the community. Mental health is an important dimension of the students’ health as the future decision - makers of the country. This group is exposed to a large number of stresses due to their sensitive age and social status. Factors such as geographical distance between home and the school, separation from the family, entry into a new environment, learning issues and problems, competition with other students, future occupational status, and dormitory living can be considered as the available sources of stress in the students. Stress can lead to the incidence of physical and mental illnesses (
2). Depression and anxiety can be referred to as mental illnesses and symptoms caused by stress. Stress, anxiety, and depression are among the mental health factors that may lead to interference between the expected roles and the health responsibilities in the future, in addition to the problems that may inflict on students. Therefore, prevention of stress, anxiety, and depression among students and reduction of mental pressure may play an important role in more interest in job duties, teamwork, and the sense of responsibility (
3). Cognitive emotion regulation is defined as the management of emotionally excited information via cognitive strategies of consciousness (
4). Emotional regulation refers to processes by which one can influence what emotions to experience, when to experience, and how to express them (
5). In emotional regulation, an optimal interaction of cognition and emotion is necessary to cope with the adverse conditions (
6). There is a relationship between cognitive system functions and mood changes; therefore, the role of cognitive emotion regulation in adapting individuals to stressful life events cannot be ignored (
7). In the new approaches, the cause of emotional disturbances is attributed to defects in cognitive controls, to such an extent that the inability to control negative emotions results from the existence of negative thoughts and beliefs about worries and the use of inefficient coping methods (
8). Self - blame, rumination, and catastrophic thinking are reported as the strong predictors for negative emotions (
9). Cognitive emotional regulation strategies help people to regulate excitements and negative emotions. This regulation method establishes a direct relationship between growth, progression, or incidence of mental disorders (
10). Findings of different studies demonstrated that the patterns of mental injury and emotional regulation are in full consistency with each other (
11,
12). The use of some strategies, including self - blame, rumination, and catastrophic thinking, and other - blame are more common among adults with mental disorders (
7,
9). Research literature shows that the prevalence of anxiety and depression is higher in females. On the other hand, researches showed that males use self - blame and catastrophic thinking strategies to a larger extent than females. Therefore, it seems that males are more likely to react negatively to unfortunate events and try to hold cognitive control over the events since they blame themselves for the events (
13). Therefore, the current research aimed at predicting anxiety and depression through negative emotions among the medical students of Shiraz University of Medical Sciences, Shiraz, Iran.