Multiple paraphilia is characterized as a disorder that includes three or more paraphilias (
1). It has been shown that multiple paraphilias is very prevalent in individuals previously assumed to have only one paraphilia (
2). Paraphilia is defined as “any intense and persistent sexual interest other than the genital stimulation or preparatory fondling with human partners satisfying with normal mature physical and phenotype” (
3). It is hard to estimate the prevalence rates of paraphilias due to changes in criterion with time and with divergent cultures (
4). On the other hand, paraphilias is often kept as a secret with the patient as it is stigmatized in the society; therefore, the prevalence of paraphilia is underestimated and a non-accurate estimation is yielded. Paraphilia previously known as sexual perversion and sexual deviation, includes zoophilia, sexual sadism, exhibitionism, and pedophilia etc (
3). Paraphilia often leads to misery and clinically significant damages and eventually results in important ethical and public health problems (
5). As a result, the treatment of paraphilia is of prominent importance to be considered. Cognitive-behavioral therapy has been a principal way to treat sex offenders or individuals with paraphilias (
6). Furthermore, there are three categories of pharmacologic agents often applying to effectively treat patients with paraphilia. Selective serotonin reuptake inhibitor (SSRI), synthetic steroid analogs, and Gonadotropin-releasing hormone (GnRH) analogs are the medications utilized in an effective treatment of the patients, yet some algorithm existed for treating different severity of the disorder (
7).