This study was conducted to investigate the harmful behaviors in drug abusers. Of 99 cases who were suffering from drug abuse, 85 individuals had shown some kind of harmful behavior. This may not be generalizable to the entire population who use different kinds of drugs. That is because the study had been conducted on those who were referred to psychiatric hospitals. Therefore, it is likely that the severity of the disorder and associated diseases be more causal than of the whole of drug abusers in the community. In previous studies, one of the common causes the drug-dependent individuals were referred to hospitals has been associating mental disorders such as personality problems and mood disorders (
2). Many drug abusers are also referred to health centers due to drug toxicity. However the number of individuals in this study was not high because the hospital where the study was conducted lacked a toxicology department. The number of male was much higher than female. In the former studies, most cases with drug abuse were males, although the rates of using various drugs in women are also on the rise (
2,
14,
15). In addition, most subjects were living alone (unmarried or divorced). This fact has been proved in previous studies; particularly the number of divorced individuals verifies their problems in interpersonal relations. It is interesting to note that no significant difference was found in the incidence of harmful behaviors in women and men. Some studies have shown that harmful behaviors have higher frequency in men (
2,
7). Since these types of studies had been conducted in different communities, they differed from the present study in terms of the population. Furthermore, the present study is limited to psychiatric hospital cases. Therefore, the statistical difference is justifiable with regard to this matter. None of the variables, education and marital status, were identified as being effective in the incidence of harmful behaviors. But a study conducted at Shiraz University of Medical Sciences, Iran has shown that the incidence of harmful behaviors is more common in people with lower educational levels (
16). Our study had been performed on those who lacked comorbid axis I psychiatric disorders. Thus, the design of Shiraz University investigation is different from the current study in terms of the overall structure and methodology. Few studies reported more prevalence of harmful behaviors in unmarried subjects than in married ones, have emphasized social adaptation techniques. The present study had not considered this aspect of the subject’s behaviors. Considering the incidence of harmful behaviors in this study the most common type was “aggression by force and attack”. Subsequently, “the suicidal threat” was the other important factor. Various reports have been presented in previous studies, for example in the study performed by McCloskey et al. (
17), similar to our study, aggressive behavior had been the most prevalent indicator. However, another study showed a higher incidence of suicide and self-harms (
18). The afore-mentioned study differs from the present study in that it had been done with people with personality disorders. In addition, according to Iranian cultural and religious norms, a lower incidence of suicide is reasonable. Considering the methods of suicide, the most common methods had been the use of cold weapons and pills, respectively. Given that most of the subjects were male and use of weapons was more common than pills or poison in men, the above results were predictable. None of the subjects had used firearms, perhaps due to their unavailability. However, one should also consider the fact that this method is very effective and dangerous; and death occurs so quickly that there would be no chance of saving the patient or sending him/her to a psychiatric hospital. According to our findings, the most commonly used drugs were alcohol and cannabis respectively. Use of alcohol in other studies, as the most commonly abused substance, had been proven (
8,
19). Since the study was conducted on the patients of hospital wards with psychiatric disorders; therefore, the use of alcohol, as the most commonly used drug, might not be representative of the whole community. Interestingly, associated psychiatric disorders were prevalent in these patients, with bipolar disorder as most common disorder (type 1 and 2) and schizophrenia as the second. Since the research was conducted in a psychiatric hospital, higher prevalence of psychiatric disorders was understandable. Using various materials that had already been proved in mood disorders (
2) has also been approved in the present study. Since our study is among the first demographic research of drug abuse and harmful behaviors in Iran, it can be used as a guide for other studies. Nevertheless, this study also had some limitations. Since this study was conducted on hospitalized patients, generalization might be problematic. Also bigger sample size in longer period is recommended in order to obtain reliable information. Some patients might not record their substance use and therefore this study might not include all patients suffering from substance abuse disorder. Investigation of specific personality disorders as well as individuals’ methods of compliance could yield valuable information. Conducting the study in different centers and studying different demographic bases can help us in achieving more reliable results.