The global experiences and evidence of the final articles regarding future hospitals were examined, divided, and reported in the form of four categories: Designing the physical space in future hospitals, training in the space of future hospitals, providing services in future hospitals, and technology and technologies in future hospitals. Their challenges in implementing these initiatives and proposed solutions were also evaluated. Suppose we want to design a future hospital based on the needs of patients. In that case, the training of healthcare professionals and the expectations of patients, the aging population, and economic pressures will not be successful in the design of hospitals today. The design process needs to anticipate and respond to emerging issues. While inexpensive, such things benefit patients, staff, and visitors. They prove that the difference is not in cost but in the quality of the design. A better environment is not necessarily more expensive; it depends on how wisely precious resources such as time and money are spent (
8,
16). As patient care changes and evolves, flexibility is a critical issue. With strategies such as minimizing the length of hospital stay, creating a capacity for easy referral to a local facility to consult with the best specialists, new options such as telediagnosis can reduce the pressure from the large number of outpatients congregating in specialized centers, allow patients to see specialists remotely and avoid long travel time (
16,
17,
29-
32). Also, changing the treatment-oriented approach and using new plans, including entertainment in educational and leisure programs, can facilitate and accelerate the treatment process. Moreover, it makes the hospital a familiar space for patients to cooperate and participate in treatment (
19,
33). Therefore, health promotion programs can play an effective role at the macro level, including policy-making, to improve the health level of society, attention to improving the health of patients and hospital employees, and be considered as a roadmap for prioritizing and planning other health programs (
20,
21,
23). Nowadays, with rapid changes and the special role of information and technologies, one of the main Achilles heels/weaknesses of future hospitals will be the advancement of technologies, and countries are forced to have strong perspectives in communication and technology. Japan is planning medical equipment management systems, including wireless LAN and RF-ID tags and a nurse call system (NCS) connected to HIS, using VoIP. In the medical equipment management system, an RF-ID tag is attached to each medical device to prevent the loss of expensive equipment. This system also allows controlling the current location of each device. The device user can track the patient’s information, and the performance status of each device can be monitored (
18,
34). Wireless technologies are rapidly being introduced as part of the data communication infrastructure of modern hospitals. Even with concerns about the security problems of wireless communications and encryption, demand is remarkably high. In addition, it is important to ensure that the network is always available (
24). Despite all the benefits and positive aspects of the technological advances discussed, the implementation of future hospitals will face challenges. There are important challenges, such as structural (lack of proper framework, legal challenges, absence of program implementation platform) and informational challenges (data security, the leakage of data, disparities in access, Information speed) (
15-
24,
35). In future hospitals, the necessary platform and infrastructure for the safe use of these technologies should be considered, which requires effort, time, and extensive research (
18,
24). On the other hand, the challenges that may occur during the implementation of the plans should be considered. The necessary investigations should be done to solve them, which include electromagnetic interference (EMI) with medical devices, loudspeakers, or bells, inappropriate disclosure of personal information using the video/camera recording function, and not concentrating on work while talking on the phone; data leakage, unauthorized visual access to the screen of portable terminals and incorrect screen copying (
15,
18,
24). Due to the relationship of success of future hospital implementation and the implementation process itself, planning a successful pilot plan, the structural and procedural requirements necessary for broader adoption can be established, ensuring that new technology integrates seamlessly with existing tools and workflows (
36-
39). In this path, to increase the likelihood of project success, attention should be paid to training users, creating a committed attitude and supporting managers with the project, using successful steering groups to facilitate communication. The ongoing support from the organization in providing guidance, keeping local staff up to date with national and international developments, facilitating connections with others and providing access to learning and resources can also provide the platform for the adoption of new technologies in the hospital environment and among staff (
21,
24). Hence, moving away from expensive and overly complex software towards readily available programs to perform simple tasks. In the future, large healthcare institutions may earn much less from simple procedures like outpatient blood tests and rely more on major procedures to cover their costs. In line with these advances and modern designs, it is possible to pave the way for the development of hospitals in all parts of the world with economic savings and witness health improvement for all societies.