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Background:
The transforming growth factor-? (TGF-?) is an important cytokine with anti-inflammatory properties.
Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
High Serum Levels of TGF-? in Iranians With Chronic HBV Infection
Authors
Hossein Khorramdelazad1, Gholamhossein Hassanshahi1, Behzad Nasiri Ahmadabadi2, Mohammad Kazemi Arababadi2,*
1Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
2Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
*Corresponding Author: Corresponding author: Mohammad Kazemi Arababadi, Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran. Tel.: +98-3915234003-5, Fax: +98-3915225209, E-mail:, dr.kazemi@rums.ac.ir. Email: dr.kazemi@rums.ac.ir
Published online:Nov 04, 2012
Article type:Brief Report
Received:Aug 02, 2012
Accepted:Sep 16, 2012
How to Cite:Khorramdelazad H, Hassanshahi G, Nasiri Ahmadabadi B, Kazemi Arababadi M. High Serum Levels of TGF-? in Iranians With Chronic HBV Infection. Hepat Mon. 2012;12(11):7581. doi: https://doi.org/10.5812/hepatmon.7581
Abstract
Objectives:
The main purpose of this study was to compare the serum levels of TGF-? in a group of chronic HBV infected (CHB) patients as well as healthy individuals from South-East of Iran.
Patients and Methods:
Sixty patients with CHB as well as sixty healthy individuals were enrolled in the study. ELISA technique was applied to measure the serum levels of TGF-? in both groups.
Results:
Our results revealed that the serum levels of TGF-? were significantly increased in CHB patients in compare to healthy controls.
Conclusions:
According to this result, it may be concluded that high serum levels of TGF-? may be a mechanism by which immune response against HBV is suppressed.
Highlights
Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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