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Jundishapur Journal of Microbiology

Ahvaz Jundishapur University of Medical Sciences

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https://doi.org/10.5812/jjm.6236

Rapid Detection of Acute Respiratory Virus and Atypical Bacteria Infections in Children

Author(s):
Cai XuanCai Xuan1,*, Li YanLi Yan1, Wu ZegangWu Zegang1
1Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China
Jundishapur Journal of Microbiology:Vol. 6, issue 5; 6236
Published online:Jun 30, 2013
Article type:Research Article
Received:May 06, 2012
Accepted:Aug 07, 2012
How to Cite:Xuan C, Yan L, Zegang W. Rapid Detection of Acute Respiratory Virus and Atypical Bacteria Infections in Children. Jundishapur J Microbiol. 2013;6(5):6236. doi: https://doi.org/10.5812/jjm.6236

Abstract

Background:

Acute respiratory infection (ARI) is one of the primary diseases that cause high morbidity and mortality to children especially in developing countries. ARI can come from a number of pathogens, which are not necessarily identical in different regions or groups. As similar symptoms become evident in child ARI without specific particularities, respiratory infectious diseases are most of the time clinically diagnosed and treated less selectively than required, and antibiotics are largely used for non-bacterial respiratory system infections. Therefore, rapid detection of respiratory pathogens is necessary for the correct and appropriate treatment of ARI.

Objectives:

To obtain a general understanding of the pathogenic spectrum of ARI for children and provide basis for clinical infection control and pathogenic detection.

Materials and Methods:

Serum specimens from 4550 child victims with ARI symptoms were collected and detected for IgM antibodies of nine common pathogens using the indirect immunofluorescence assay (IFA).

Results:

Of the 4550 child victims, 3660 were antibody positive (80.4%), with detectable rates of 67.3%, 90.9%, 92.4% and 91.4% for the ? 1, 1< y ? 3, 3 < y ? 6 and > 6 age groups respectively (P < 0.05). Except for Coxiellaburneti (COX), the difference in the detectable rates of other pathogens between the groups was statistically significant. Of the nine pathogens, Mycoplasma pneumoniae (MP) had the highest detectable rate, followed by influenza B virus (FluB), respiratory syncytial virus (RSV), parainfluenza virus (PIV), adenovirus (ADV), influenza A virus (FluA), Legionella pneumophila sero group I (LPN-I), Coxiellaburneti (COX) and Chlamydia pneumoniae (CPn); and 718 suffered mixed infections (81.4%), typically of two pathogens (MP + FLuB).

Conclusions:

MP, FluB and RSV are the principal contributors to ARI in the Hubei area, with mixed infections, typically of MP and FluB, being the most common pathogens statistically significant between different age groups.

Keywords
Child
Respiratory Tract Infections
Pathogen
Coinfection

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