The Neuroprotective Effects of Astaxanthin on Anxiety-Like Behaviors and Oxidative Stress in the Cortex of Ethanol Model Mice

Hajizadeh Moghadam, Akbar; Baradaran Paien Rodposhti, Masoumeh; Khanjani Jolodar, Sedigheh; Farhadi Pahnedari, Soroush

doi:10.5812/koomesh-153385

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Journal of Semnan University of Medical Sciences

e-ISSN 2345-3699

p-ISSN 1608-7046

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Outline

Abstract
References
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https://doi.org/10.69107/koomesh-153385

The Neuroprotective Effects of Astaxanthin on Anxiety-Like Behaviors and Oxidative Stress in the Cortex of Ethanol Model Mice

Authors

Akbar Hajizadeh Moghadam

^1,*, Masoumeh Baradaran Paien Rodposhti

¹, Sedigheh Khanjani Jolodar², Soroush Farhadi Pahnedari

²

1Department of Animal Biology, Faculty of Sciences, University of Mazandaran, Babolsar, Iran

2Department of Animal Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran

*Corresponding Author: Department of Animal Biology, Faculty of Science, University of Mazandaran, Babolsar, Iran. Email:a.hajizadeh@umz.ac.ir

Koomesh:Vol. 26, issue 6; e153385

Published online:Feb 24, 2025

Article type:Research Article

How to Cite:Hajizadeh Moghadam A, Baradaran Paien Rodposhti M, Khanjani Jolodar S, Farhadi Pahnedari S. The Neuroprotective Effects of Astaxanthin on Anxiety-Like Behaviors and Oxidative Stress in the Cortex of Ethanol Model Mice. Koomesh. 2024;26(6):e153385. doi: https://doi.org/10.69107/koomesh-153385

Abstract

Background: Ethanol is a narcotic and psychedelic substance, the use of which causes oxidative stress in the brain and behavioral changes such as anxiety. The production of free radicals and oxidative stress causes the effects of ethanol.

Objectives: This study aimed to investigate the neuroprotective effects of astaxanthin on anxiety-like behaviors and oxidative stress in the cortex of ethanol model mice.

Methods: 35 adult male mice were divided into 5 groups (n=7) including control, astaxanthin, ethanol, and 2 groups treated with astaxanthin at 10 and 20 mg/kg. Behavioral tests including elevated plus maze test (EPMT) and open field test (OFT) and activities of glutathione peroxidase (GPx), glutathione S-transferase (GST), and level of glutathione (GSH) in the cortex tissue were measured.

Results: Based on the results, ethanol significantly increased line crossing and decreased the time spent and the number of entries into the open arm, center duration, enzyme activities, and glutathione level compared to the control group. Astaxanthin significantly decreased line crossing and increased time spent and the number of entries into the open arm, center duration, enzyme activities, and glutathione level compared to the ethanol group.

Conclusion: This research showed that astaxanthin treatment improves anxiety-like behaviors and effectively protects cortical areas against ethanol-induced oxidative stress. Therefore, astaxanthin can be used as a medicinal supplement to improve ethanol-induced behavioral and oxidative damage.

Highlights

KeywordsEthanol Oxidative stress Anxiety Astaxanthin Mice

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© 2024, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

Outline

The Neuroprotective Effects of Astaxanthin on Anxiety-Like Behaviors and Oxidative Stress in the Cortex of Ethanol Model Mice

Abstract

Highlights

References

Copyright

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