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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
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Molecular Aspects of Glucose-6-Phosphate Dehydrogenase Deficiency in Iran
Author(s):
1Department of Pathology, Zanjan University of Medical Sciences, Zanjan, Iran
2Department of Hematology, Thalassemia and Hemoglobinopathy Research Center, Jundi Shapur University of Medical Sciences, Ahvaz, Iran
3Department of Hematology, Division of Laboratory Hematology and Blood Banking, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Department of Pathology, Zanjan University of Medical Sciences, Zanjan, Iran Email: [email protected]
Published online:Jan 07, 2012
Article type:Review Article
Received:Aug 27, 2011
Accepted:Nov 16, 2011
How to Cite:Dehghanifard A, Mortazavi Y, Saki N, Farshdusti-Hagh M. Molecular Aspects of Glucose-6-Phosphate Dehydrogenase Deficiency in Iran. Zahedan J Res Med Sci. 2012;14(7):e93302. doi:
Abstract
Background: G6PD deficiency is the most common hereditary enzyme deficiency that affected more than 400 million people worldwide. This enzyme deficiency is caused by a spectrum of mutations in the gene encoding G6PD on chromosome X. Epidemiologically G6PD deficiency has been specially considered in Middle East countries including Iran, Oman and Saudi Arabia.
Materials and Methods: This study has reviewed more than 70 papers related to the epidemiological significance and various diagnostic strategies of G6PD deficiency from 1956 to 2010.
Results: The results showed a higher prevalence of Mediterranean variant followed by Chatham and Cosenza compared to other variants in Iran.
Conclusion: Accurate identification of G6PD deficiency variants in areas with high prevalence of this disease will help to screen patients and their families with risk level when faced with oxidant agents.
References
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Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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