Study of Antibacterial Effect of Novel Thiazole, Imidazole, and Tetrahydropyrimidine Derivatives against Listeria Monocytogenes

Behzad Ghasemi; Hamid  Beyzaei; Hadi  Hashemi

Annals of Military and Health Sciences Research

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Study of Antibacterial Effect of Novel Thiazole, Imidazole, and Tetrahydropyrimidine Derivatives against Listeria Monocytogenes

Author(s):

Behzad Ghasemi^1,*,

Hamid Beyzaei²,

Hadi Hashemi³

1Department of Pathobiology, Faculty of Veterinary, University of Zabol, Zabol, Iran., Andorra

2Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran, Andorra

3Department of Clinical Sciences, Faculty of Veterinary, University of Zabol, Zabol, Iran., Andorra

Annals of Military and Health Sciences Research:Vol. 13, issue 3; e58318

Published online:Sep 14, 2015

Article type:Research Article

Received:Jul 14, 2015

Accepted:Aug 14, 2015

How to Cite:Ghasemi B, Beyzaei H, Hashemi H, Study of Antibacterial Effect of Novel Thiazole, Imidazole, and Tetrahydropyrimidine Derivatives against Listeria Monocytogenes.Ann Mil Health Sci Res.2015;13(3):e58318.

Abstract

Purpose: In this study, we have focused on antibacterial effect of newly synthesized thiazole, imidazole, and tetrahydropyrimidine derivatives in Iran on listeria monocytogenes. Materials and Methods: For evaluation of antibacterial effect, the disk diffusion method was applied to measure the growth inhibition zone diameter and broth micro dilution was performed to determine the minimum inhibitory concentration. Results: Assessing the antibacterial effect showed that only thiazole derivative 6d had inhibitory effect on listeria monocytogenes and the other thiazole, imidazole and tetrahydropyrimidine derivatives lacked any inhibitory clue on this organism. The inhibitory effect of thiazole derivative 6d was shown by minimum inhibitory concentration = 64 and growth inhibition zone diameter = 23 ± 0.1. In antibiogram test, also the most susceptibility was recorded for gentamicin and penicillin with minimum inhibitory concentration = 1 µg/mL. Conclusion: The antibacterial effect of thiazole, imidazole and tetrahydropyrimidine derivatives differs from each other and cross connections such as linkage of oxygen to thiazole ring in derivative 6d, could reinforce this effect. By proving the in vitro antibacterial effect of the novel thiazole derivative on listeria monocytogenes, to more recognize this compound, next step is determining the toxicity and therapeutic effects in laboratory animals.

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