Association of estrogen receptor 1 rs9340799 polymorphism with implantation failure in Iranian infertile women

authors:

avatar Hadi Mirzapour-Delavar 1 , * , avatar Azita Shafighian 1 , avatar Zahra Shahidi 2

Clinic of IVF and Infertility Treatment, Besat Hospital, Tehran, Iran., Andorra
Clinic of IVF and Infertility Treatment, Besat Hospital, Tehran, Iran, Andorra
Annals of Military and Health Sciences Research: Vol.12, issue 3; e63283
published online: September 25, 2014
article type: Original Article
received: July 23, 2014
accepted: August 22, 2014

how to cite: Mirzapour-Delavar H, Shafighian A , Shahidi Z. Association of estrogen receptor 1 rs9340799 polymorphism with implantation failure in Iranian infertile women. Ann Mil Health Sci Res. 2014;12(3):e63283. 

Abstract

Materials and Methods: Hundred two infertile women with at least one IVF failure were enrolled in the study as the case group and 112 healthy women as the control group. The restriction fragment length of polymorphism method was performed for genotyping the single nucleotide polymorphism rs9340799 (A/G XbaI) located in intron 1 of ESR1 gene. The result  was confirmed by DNA sequencing   analysis.

Results: The genotype distribution of AA in case and control groups was 40 (39.2%) and 55 (49.1%), respectively. However, genotype distribution of AG was 41 (40.2%) and 47 (41.9%). Ultimately genotype distribution of GG was 21 (20.6%) and 10 (9%). There was a statistically significant difference between case and control groups in the genotype distribution of XbaI polymorphism  (P = .04).

Conclusion: There was an association between single nucleotide polymorphism ESR1 rs9340799 and implantation failure in Iranian infertile women who underwent IVF procedure.

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