Association of estrogen receptor 1 rs9340799 polymorphism with implantation failure in Iranian infertile women

Hadi Mirzapour-Delavar; Azita  Shafighian; Zahra  Shahidi

Annals of Military and Health Sciences Research

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Association of estrogen receptor 1 rs9340799 polymorphism with implantation failure in Iranian infertile women

Author(s):

Hadi Mirzapour-Delavar ^1,*,

Azita Shafighian¹,

Zahra Shahidi²

1Clinic of IVF and Infertility Treatment, Besat Hospital, Tehran, Iran., Andorra

2Clinic of IVF and Infertility Treatment, Besat Hospital, Tehran, Iran, Andorra

Annals of Military and Health Sciences Research:Vol. 12, issue 3; e63283

Published online:Sep 25, 2014

Article type:Research Article

Received:Jul 23, 2014

Accepted:Aug 22, 2014

How to Cite:Hadi Mirzapour-Delavar Azita ShafighianZahra ShahidiAssociation of estrogen receptor 1 rs9340799 polymorphism with implantation failure in Iranian infertile women.Ann Mil Health Sci Res.12(3):e63283.

Abstract

Materials and Methods: Hundred two infertile women with at least one IVF failure were enrolled in the study as the case group and 112 healthy women as the control group. The restriction fragment length of polymorphism method was performed for genotyping the single nucleotide polymorphism rs9340799 (A/G XbaI) located in intron 1 of ESR1 gene. The result was confirmed by DNA sequencing analysis.

Results: The genotype distribution of AA in case and control groups was 40 (39.2%) and 55 (49.1%), respectively. However, genotype distribution of AG was 41 (40.2%) and 47 (41.9%). Ultimately genotype distribution of GG was 21 (20.6%) and 10 (9%). There was a statistically significant difference between case and control groups in the genotype distribution of XbaI polymorphism (P = .04).

Conclusion: There was an association between single nucleotide polymorphism ESR1 rs9340799 and implantation failure in Iranian infertile women who underwent IVF procedure.

Keywords

implantation failure

estrogen receptor 1 gene

single nucleotide polymorphism

infertility

genotype distribution.

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