Her2/neu Expression in Wilms' Tumor and Correlation With Histopathologic Findings

Mashaallah Babashahi; Mitra  Mehrazma; Seyed Javad  Nasiri; Farid Azizi Jalilian; Mostafa Rezaei-Tavirani

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Her2/neu Expression in Wilms' Tumor and Correlation With Histopathologic Findings

Author(s):

Mashaallah Babashahi¹,

Mitra Mehrazma^2,*,

Seyed Javad Nasiri³,

Farid Azizi Jalilian⁴,

Mostafa Rezaei-Tavirani⁵

1Dept. of Pathology, Iran University of Medical Sciences, Tehran, Iran

2Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran

3Dept. of Pathology , Ali-Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran

4Dept. of Medical Microbiology, Ilam University of Medical Sciences, Ilam, Iran

5Proteomics Research Center, ShahidBeheshti University of Medical Sciences, Tehran, Iran

International Journal of Cancer Management:Vol. 6, issue 3; e80429

Published online:Sep 30, 2013

Article type:Research Article

Received:Jan 02, 2013

Accepted:Feb 14, 2013

How to Cite:Mashaallah BabashahiMitra MehrazmaSeyed Javad NasiriFarid Azizi JalilianMostafa Rezaei-TaviraniHer2/neu Expression in Wilms' Tumor and Correlation With Histopathologic Findings.Int J Cancer Manag.6(3):e80429.

Abstract

Background: Wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. Her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival.

Methods: In the current study, we analyzed Her2/neu expression in 40 Wilms' tumors. The clinico-demographic data of 40 patients with Wilms' tumor were retrieved. Immunohistochemical staining for HER2/neu was performed. Her2/neuimmunoreactivity was evaluated by Canadian Consensus 2007 scoring system.

Results: Among the 38 specimens with epithelial component, 68.5% were positive for Her2/neu, whereas there was immunoreactivity in 37% of 38 blastemal, and 12% of 31 stromal components. The Her2/neu expression was significantly higher in early stages (81.5%) than in advanced stages (36.4%) in epithelial component, but not in other components.

Conclusion: This study suggested that Her2/neuexpression is associated with epithelial cell differentiation accompanied by lower stages of tumor. No significant relationship was found between Her2/neu positivity and tumor size and patient's age and gender.

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