Cerebellar Neuroblastoma in 2.5 Years Old Child

Mohammad  Pedram; Majid Vafaie; Kiavash Fekri; Sabahat Haghi; Iran Rashidi; Chia Pirooti

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Cerebellar Neuroblastoma in 2.5 Years Old Child

Author(s):

Mohammad Pedram^1,*,

Majid Vafaie¹,

Kiavash Fekri¹,

Sabahat Haghi¹,

Iran Rashidi²,

Chia Pirooti³

1Thalassemia and Hemoglobinopathy Research Center, Ahvaz Jondishapur University of Medical Sciences, Ahvaz, Iran

2Dept. of Pathology, Shafa Hospital , Ahvaz Jondishapur University of Medical Sciences, Ahvaz, Iran

3Dept. of Neurosurgery, Golestan Hospital, Ahvaz Jondishapur University of Medical Sciences, Ahvaz, Iran

International Journal of Cancer Management:Vol. 6, issue 3; e80434

Published online:Sep 30, 2013

Article type:Case Report

Received:Jan 02, 2012

Accepted:Feb 18, 2012

How to Cite:Mohammad PedramMajid VafaieKiavash FekriSabahat HaghiIran RashidiChia Pirootiet al.Cerebellar Neuroblastoma in 2.5 Years Old Child.Int J Cancer Manag.6(3):e80434.

Abstract

Neuroblastoma is the third most common malignancy of childhood, after leukemia and brain tumors. Only 2% of all neuroblastoma occur in the brain. Primary cerebellar neuroblastoma is an specific subset of Primitive Neuroectodermal Tumors (PNET). Meduloblastoma is a relatively common and well-established entity, consisting of primitive and multipotential cells that may exhibit some evidence of neuroblastic or gliad differentiation. But cerebellar neuroblastoma with ultrastractural evidence of significant neuroblastic differentiation is extremely rare. We report a rare case of neuroblastoma in the cerebellum. A 2.5-year-old Iranian boy presented with vomiting and nausea in the morning and ataxia. CT scan showed a tumor mass in the cerebellum and the report of radiologist was medulloblastoma. Light microscopic assay showed a small cell neoplasm with lobules of densely packed cells (lobulated pattern) and better differentiated cells. Neuron-Specific Enolase was positive. Pathologic diagnosis confirmed the existence of cerebellar neuroblastoma. Chemotherapy followed surgical removal. No relapse occurred 12 months after surgery.

Keywords

Neuroblastoma

Cerebellum

Chemotherapy

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