Severe Hypertension and Encephalopathy Due to Renin-Producing Hepatoblastoma

Azita Tavasoli; Mitra Mehrazma; Nakisa Hooman; Ladan Afshar Khas

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Severe Hypertension and Encephalopathy Due to Renin-Producing Hepatoblastoma

Author(s):

Azita Tavasoli^1,*,

Mitra Mehrazma²,

Nakisa Hooman³,

Ladan Afshar Khas¹

1Dept. of Pediatric Neurology, Ali Asghar Hospital, Tehran University of Medical Sciences, Tehran, Iran

2Oncopathology Research Center, Tehran University of Medical Sciences, Tehran, Iran

3Dept. of Pediatrics Nephrology, Ali Asghar Hospital, Tehran University of Medical Sciences, Tehran, Iran

International Journal of Cancer Management:Vol. 6, issue 4; e80483

Published online:Dec 30, 2013

Article type:Case Report

Received:Jan 06, 2011

Accepted:Mar 28, 2011

How to Cite:Azita TavasoliMitra MehrazmaNakisa HoomanLadan Afshar KhasSevere Hypertension and Encephalopathy Due to Renin-Producing Hepatoblastoma.Int J Cancer Manag.2013;6(4):e80483.

Abstract

Paraneoplastic syndromes result from secretion of hormones, peptides or cytokines by tumor or immune cross-reactivity between malignant and normal tissues. These conditions are rare in children, but when the clinical presentation of patients with a tumor is unusual, these syndromes should be emphasized. Extrarenal tumors with renin-secretion are rare in children. They may be related to paraneoplastic syndromes. We report a 22-month-old infant with hepatoblastoma presented with severe hypertension and related neurologic symptoms due to high plasma renin activity. To the best of our knowledge, this is the second report of renin producing hepatoblastoma in the literature. However, due to lack of laboratory facilities such as immunohistochemical study or polyclonal antibody for human renin activity, we could not prove the secretion of renin just by tumor tissue cells, but this potentiality is very likely. Other intensive investigations did not show any other origin for rennin secretion or hypertension in this patient.

Keywords

Hepatoblastoma

Hypertension

Paraneoplastic syndromes

Renin

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