Extensive Hematoma in a Patient with HereditaryHypersegmentation of Neutrophils

21. Department of Hematology and BloodTransfusion, School of Allied MedicalSciences, Iran University of MedicalSciences, Tehran, Iran2. Human Genetics Research Center,Baqiyatallah University of MedicalSciences Tehran, Iran

3Department of Hematology and BloodTransfusion, School of Allied MedicalSciences, Iran University of MedicalSciences, Tehran, Iran

4Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

51. Department of Hematology and BloodTransfusion, School of Allied MedicalSciences, Iran University of MedicalSciences, Tehran, Iran2. Department of Laboratory Sciences,Paramedical Faculty, Babol Universityof Medical Sciences, Babol, Iran

6Tehran Heart Center (THC), TehranUniversity of Medical Sciences, Tehran,Iran

Journal of Cellular & Molecular Anesthesia:Vol. 1, issue 3; e149513

Published online:Jul 23, 2016

Article type:Brief Communications

How to Cite:Akbar DorgalalehBehnaz TavasoliShadi TabibianShahrzad SouriGolbahar MajidMahmood ShamsJamal RashidpanahFereshteh Firoozkohiet al.Extensive Hematoma in a Patient with HereditaryHypersegmentation of Neutrophils.J Cell Mol Anesth.1(3):e149513.https://doi.org/10.22037/jcma.v1i3.11878.

Abstract

?Erratum:?The correct affiliation of corresponding author of this manuscript has been edited as follows:"Akbar Dorgalaleh: Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran."Hypercoagulable states are a group of conditions associated with an enhanced?tendency toward blood clotting. Although usual clinical manifestations of hypercoagulable states are thrombotic events?such as deep venous thrombosis, hematoma can also?occurs as a result of hypercoagulability in some patients. Several inherited or acquired conditions?may lead to hypercoagulable states. Some of them include myeloproliferative syndromes, over activity of?coagulation factors and methyltetrahydrofolateee reductase (MTHFR) polymorphisms. MTHFR is required for convertingthe amino acid?? homocysteine to methionine. Another significant role of an aptly functioning MTHFR enzyme is nucleic acid biosynthesis. Therefore MTHFR polymorphisms are expected to be associated with?hypersegmentation of neutrophils because of a defect in DNA metabolism. Neutrophil hypersegmentation is one of the most sensitive haematological features of cobalamin or folate deficiency with normal serum vitamin B12-folic acid and iron levels. Hypersegmentation of neutrophils and hematoma which? both of them suspected to be? due to gene variations of MTHFR. Here we report a 37 years old female who simultaneously affected by hereditary hypersegmentation and extensive hematoma. Laboratory analysis revealed normal serum vitamin B12, folic acid and iron levels. Routine and specific coagulation tests were normal in except of factor VIIIc that was high. Results of complete blood cell count (CBC) test were normal. Although this is just an idea, but simultaneous presentations of these two conditions can have a common origin.

Keywords

Hematoma

Neutrophil hyper-segmentation

Hypercoagulability

References

1.
References are in the PDF file of the article.

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef 0

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Akbar Dorgalaleh:[PubMed][Scholar]
Behnaz Tavasoli:[PubMed][Scholar]
Shadi Tabibian:[PubMed][Scholar]
Shahrzad Souri:[PubMed][Scholar]
Golbahar Majid:[PubMed][Scholar]
Mahmood Shams:[PubMed][Scholar]
Jamal Rashidpanah:[PubMed][Scholar]
Fereshteh Firoozkohi:[PubMed][Scholar]