Extensive Hematoma in a Patient with HereditaryHypersegmentation of Neutrophils

21. Department of Hematology and BloodTransfusion, School of Allied MedicalSciences, Iran University of MedicalSciences, Tehran, Iran2. Human Genetics Research Center,Baqiyatallah University of MedicalSciences Tehran, Iran

3Department of Hematology and BloodTransfusion, School of Allied MedicalSciences, Iran University of MedicalSciences, Tehran, Iran

4Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

51. Department of Hematology and BloodTransfusion, School of Allied MedicalSciences, Iran University of MedicalSciences, Tehran, Iran2. Department of Laboratory Sciences,Paramedical Faculty, Babol Universityof Medical Sciences, Babol, Iran

6Tehran Heart Center (THC), TehranUniversity of Medical Sciences, Tehran,Iran

Journal of Cellular & Molecular Anesthesia:Vol. 1, issue 3; e149513

Published online:Jul 23, 2016

Article type:Brief Communications

How to Cite:Dorgalaleh A, Tavasoli B, Tabibian S, Souri S, Majid G, et al. Extensive Hematoma in a Patient with HereditaryHypersegmentation of Neutrophils. J Cell Mol Anesth. 2016;1(3):e149513. doi: https://doi.org/10.22037/jcma.v1i3.11878

Abstract

?Erratum:?The correct affiliation of corresponding author of this manuscript has been edited as follows:"Akbar Dorgalaleh: Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran."Hypercoagulable states are a group of conditions associated with an enhanced?tendency toward blood clotting. Although usual clinical manifestations of hypercoagulable states are thrombotic events?such as deep venous thrombosis, hematoma can also?occurs as a result of hypercoagulability in some patients. Several inherited or acquired conditions?may lead to hypercoagulable states. Some of them include myeloproliferative syndromes, over activity of?coagulation factors and methyltetrahydrofolateee reductase (MTHFR) polymorphisms. MTHFR is required for convertingthe amino acid?? homocysteine to methionine. Another significant role of an aptly functioning MTHFR enzyme is nucleic acid biosynthesis. Therefore MTHFR polymorphisms are expected to be associated with?hypersegmentation of neutrophils because of a defect in DNA metabolism. Neutrophil hypersegmentation is one of the most sensitive haematological features of cobalamin or folate deficiency with normal serum vitamin B12-folic acid and iron levels. Hypersegmentation of neutrophils and hematoma which? both of them suspected to be? due to gene variations of MTHFR. Here we report a 37 years old female who simultaneously affected by hereditary hypersegmentation and extensive hematoma. Laboratory analysis revealed normal serum vitamin B12, folic acid and iron levels. Routine and specific coagulation tests were normal in except of factor VIIIc that was high. Results of complete blood cell count (CBC) test were normal. Although this is just an idea, but simultaneous presentations of these two conditions can have a common origin.

Keywords

Hematoma

Neutrophil hyper-segmentation

Hypercoagulability

References

1.
References are in the PDF file of the article.

Laboratory Diagnosis of Myeloperoxidase Deficiency: A Case Report.

Zahra Pourmehdi,

Seyedkamaleddin Tabatabaei,

Seyedahmadreza Salimbahrami,

Shiva Borzouei

Pourmehdi Z, Tabatabaei S, Salimbahrami S, Borzouei S. Laboratory Diagnosis of Myeloperoxidase Deficiency: A Case Report.. Shiraz E-Med J. 2012;13(1):e93925. doi:

16

Mar

2016

Laboratory Diagnosis of Congenital Factor V Deficiency, Routine, Specific Coagulation Tests with Molecular Methods

Shadi Tabibian,

Ahmad Kazemi,

Akbar Dorgalaleh

Tabibian S, Kazemi A, Dorgalaleh A. Laboratory Diagnosis of Congenital Factor V Deficiency, Routine, Specific Coagulation Tests with Molecular Methods. J Cell Mol Anesth. 2016;1(2):e149507. doi: https://doi.org/10.22037/jcma.v1i2.10790

29

Sep

2023

Carrier State of Chronic Granulomatous Disease Presented at Middle Age: A Case Report

Mahsa Rekabi,

Mohammad Behgam Shadmehr,

Esmaeil Mortaz,

Vahab Rekabi,

Maryam Heydarazad,

Sepideh Darougar

Rekabi M, Shadmehr MB, Mortaz E, Rekabi V, Heydarazad M, et al. Carrier State of Chronic Granulomatous Disease Presented at Middle Age: A Case Report. Shiraz E-Med J. 2023;24(10):e139276. doi: https://doi.org/10.5812/semj-139276

1

Oct

2011

Non-Functional Pituitary Macroadenoma presented with Chronic Anemia

N Valizadeh,

N Valizadeh

Valizadeh N, Valizadeh N. Non-Functional Pituitary Macroadenoma presented with Chronic Anemia. Shiraz E-Med J. 2011;12(4):. doi:

29

Nov

2012

Plasma Homocystein elevelsin subjects with Deep Vein Thrombosis (DVT) and non- DVT

Mehdi Zobeiri,

Alireza Hajiabadi,

Mansour Rezaei

Zobeiri M, Hajiabadi A, Rezaei M. Plasma Homocystein elevelsin subjects with Deep Vein Thrombosis (DVT) and non- DVT. J Kermanshah Univ Med Sci. 2012;16(4):e78786. doi:

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Author(s):

Akbar Dorgalaleh:[PubMed][Scholar]
Behnaz Tavasoli:[PubMed][Scholar]
Shadi Tabibian:[PubMed][Scholar]
Shahrzad Souri:[PubMed][Scholar]
Golbahar Majid:[PubMed][Scholar]
Mahmood Shams:[PubMed][Scholar]
Jamal Rashidpanah:[PubMed][Scholar]
Fereshteh Firoozkohi:[PubMed][Scholar]

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Extensive Hematoma in a Patient with HereditaryHypersegmentation of Neutrophils

Abstract

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