Regenerative Medicine And Perioperative Hypoxic Organ Damage: Targeting Hypoxia-Inducible Factors

authors:

avatar Soudeh Tabashi ORCID 1 , * , avatar Ardeshir Tajbakhsh ORCID 2 , avatar Mastaneh Dahi Taleghani ORCID 2 , avatar Shide Dabir ORCID 2 , avatar Maryam Vosoughian ORCID 2 , avatar Mohammadreza Moshari ORCID 2

Anesthesiology Research Center and Anesthesiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Anesthesia Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Journal of Cellular & Molecular Anesthesia: Vol.6, issue 4; e149735
article type: Review
DOI: https://doi.org/10.22037/jcma.v6i4.34958

how to cite: Tabashi S, Tajbakhsh A, Dahi Taleghani M, Dabir S, Vosoughian M, et al. Regenerative Medicine And Perioperative Hypoxic Organ Damage: Targeting Hypoxia-Inducible Factors. J Cell Mol Anesth. 2021;6(4):e149735. https://doi.org/10.22037/jcma.v6i4.34958.

Abstract

Regenerative medicine is defined by utilizing body?s own repair mechanisms in order to restore normal function of tissues. An important perioperative cause of organ injury is hypoperfusion mostly due to hypoxia. Hypoxia can promote genomic pathway and increase the level of hypoxia-inducible factors (HIF). In this review we introduce HIF as a pioneer role of regenerative medicine for prevention of perioperative complications.