Journal of Comprehensive Pediatrics:
Vol.1, issue 2; e93742
published online:
December
30,
2007
article type:
Research Article
received:
May
15,
2019
accepted:
December
30,
2007
Comparison of Intramuscular Injection of Single-Dose Ceftriaxone and Oral Amoxicillin in Acute Otitis Media in Children
authors:
Ali Akbar Rahbarimanesh
1
,
Houshang Akhtarharari
1
,
Peiman Salamati
1
,
Afshin shirkani
1
, *
Pediatric Department of Tehran University of Medical Sciences, 2 Social Medicine Department of Tehran University of Medical Sciences
how to cite:
Rahbarimanesh
A A, Akhtarharari
H, Salamati
P, shirkani
A. Comparison of Intramuscular Injection of Single-Dose Ceftriaxone and Oral Amoxicillin in Acute Otitis Media in Children. J Compr Ped. 2007;1(2):e93742.
Abstract
Background: The present study evaluated efficacy of a single injection of ceftriaxone 50mg/kg IM in comparison with a 10- day treatment course with oral amoxicillin 50mg/kg/d in 3 divided doses for acute otitis media in children. Materials and Methods: A randomized clinical trial was performed on 110 children between 5 months to 12yr who randomly were divided in to ceftriaxone group (n=54) and amoxicillin group (n=56) as case and control groups, respectively. Results: Demographic data and clinical manifestations of patients were similar in both groups. Forty-eight (88.9%) and 51 (91%) patients were cured in case and control groups, respectively. There was no significant different in response to therapy between the two group (p<0.05). Conclusion: This study showed that the efficacy of single injection of ceftriaxone 50mg/kg IM was equal to a 10-day treatment course with oral amoxicillin 50mg/kg/d divided in 3 doses in non-complicated acute otitis media in children.