Marine Sponge/CuO Nanocrystal: A Natural and Efficient Catalyst for Sulfonamides Synthesis

Mohammad Reza Shushizadeh; Azar Mostoufi; Marjan Fakhrian

doi:10.17795/jjnpp-3605

Jundishapur Journal of Natural Pharmaceutical Products

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

Outlines

Abstract
Copyright

https://doi.org/10.17795/jjnpp-3605

Marine Sponge/CuO Nanocrystal: A Natural and Efficient Catalyst for Sulfonamides Synthesis

Author(s):

Mohammad Reza Shushizadeh^1,*,

Azar Mostoufi²,

Marjan Fakhrian³

2Research Center of Marine Pharmaceutical Science, Ahwaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3Science and Research Branch-Khoozestan, Islamic Azad University, Ahvaz, Iran

Jundishapur Journal of Natural Pharmaceutical Products:Vol. 7, issue 4; e74300

Published online:Oct 07, 2012

Article type:Research Article

Received:Nov 26, 2011

Accepted:Jun 03, 2012

How to Cite:Mohammad Reza ShushizadehAzar MostoufiMarjan FakhrianMarine Sponge/CuO Nanocrystal: A Natural and Efficient Catalyst for Sulfonamides Synthesis.Jundishapur J Nat Pharm Prod.7(4):e74300.https://doi.org/10.17795/jjnpp-3605.

Abstract

Background: Marine sponge/nano-CuO as a natural catalyst efficiently catalyzed the Sulfonylation reaction of p-chlorobenzene sulfonyl chlorides with amines in order to prepare sulfonamides. The advantages included use of a natural catalyst, ease of handling, requirement of a very small amount of catalyst, mild reaction condition and appropriateness to high yield.

Objectives: The current study aimed to look for a solid support reaction and to develop a general, mild and novel method in order to synthesize sulfonamides in the absence of a strong base, it was found that marine sponge/nano-CuO is a natural and efficient catalyst for this method at room temperature.

Materials and Methods: The reaction was carried out simply by addition of amine and p -chlorobenzene sulfonyl chloride to the mixture of Marine sponge powder/nano-CuO in acetonitrile at room temperature. Then the reaction mixture was extracted by CH2Cl2 and was dried over anhydrous magnesium sulfate. Evaporation of the solvent afforded the products.

Results: In this method several derivatives of sulfonamide underwent the reaction of different amines with p-chlorobenzene sulfonyl chloride in the presence of marine sponge/nano-CuO in CH3CN are synthesized.

Conclusions: In conclusion, a new, natural and efficient marine catalyst, and a marine sponge/nano-CuO were developed to synthesize sulfonamide derivatives in CH3CN in 75–93% yields. This method was applied to a wide range of aromatic and aliphatic amines under mild conditions.

Keywords

Fulltext

Full text is available in PDF.

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef (3)

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Mohammad Reza Shushizadeh:[PubMed][Scholar]
Azar Mostoufi:[PubMed][Scholar]
Marjan Fakhrian:[PubMed][Scholar]