SUSTAINED RELEASE FORMULATION AND IN-VITRO EVALUATION OF IBUPROFEN-HPMC MATRIX TABLETS

MA Dabbagh; L Beitmashal

Jundishapur Journal of Natural Pharmaceutical Products

The Official Journal of Ahvaz Jundishapur University of Medical Sciences

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Abstract
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SUSTAINED RELEASE FORMULATION AND IN-VITRO EVALUATION OF IBUPROFEN-HPMC MATRIX TABLETS

Author(s):

MA Dabbagh^1,*,

L Beitmashal²

1School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, Dabbaghma@yahoo.com

2School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences

Jundishapur Journal of Natural Pharmaceutical Products:Vol. 1, issue 1; 1-7

Article type:Research Article

Received:May 29, 2004

Accepted:Nov 20, 2005

How to Cite:MA DabbaghL BeitmashalSUSTAINED RELEASE FORMULATION AND IN-VITRO EVALUATION OF IBUPROFEN-HPMC MATRIX TABLETS.Jundishapur J Nat Pharm Prod.1(1):1-7.

Abstract

Ibuprofen is one of the safest and most potent non-steroidal anti-inflammatory drug (NSAID) available in the market. To improve the bioavailability of ibuprofen, a thorough preformulation trial was undertaken. As a part of these studies, different formulations of ibuprofen containing different amounts of hydroxypropylmethylcellulose (HPMC) and microcrystalline cellulose (Avicel^®) were made and evaluated. The superior formulation which released the drug at constant rate of about 60 mg/hour was chosen. Then the effect of changing particle size of granulation was studied. Two different crystal forms of ibuprofen were prepared and their release pattern were studied. Produced crystal forms of ibuprofen showed different release mechanisms in comparison with the original form. Incorporation of various proportions of tween 80 and Sodium Lauryl Sulfate (SLS) as wetting agent on the release rate of ibuprofen in the formulations were also studied. Sodium lauryl sulphate disintegrated the tablets faster than tween 80.

Keywords

Sodium Luryl Sulphate

Tween 80.

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